JP2758766B2 - アンギオテンシンｉｉレセプタをブロツキングする２，３，６置換キナゾリノン類 - Google Patents

アンギオテンシンｉｉレセプタをブロツキングする２，３，６置換キナゾリノン類

Info

Publication number
JP2758766B2
JP2758766B2 JP4038746A JP3874692A JP2758766B2 JP 2758766 B2 JP2758766 B2 JP 2758766B2 JP 4038746 A JP4038746 A JP 4038746A JP 3874692 A JP3874692 A JP 3874692A JP 2758766 B2 JP2758766 B2 JP 2758766B2
Authority
JP
Japan
Prior art keywords
carbon atoms
quinazolinone
butyl
lower alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP4038746A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0578332A (ja
Inventor
アラナパカム・エム・ベンカテサン
ジエレミー・アイ・レビン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMERIKAN SAIANAMITSUDO CO
Original Assignee
AMERIKAN SAIANAMITSUDO CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AMERIKAN SAIANAMITSUDO CO filed Critical AMERIKAN SAIANAMITSUDO CO
Publication of JPH0578332A publication Critical patent/JPH0578332A/ja
Application granted granted Critical
Publication of JP2758766B2 publication Critical patent/JP2758766B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Fats And Perfumes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacture Of Tobacco Products (AREA)
JP4038746A 1991-01-30 1992-01-29 アンギオテンシンｉｉレセプタをブロツキングする２，３，６置換キナゾリノン類 Expired - Lifetime JP2758766B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64849291A 1991-01-30 1991-01-30
US648492 1991-01-30

Publications (2)

Publication Number Publication Date
JPH0578332A JPH0578332A (ja) 1993-03-30
JP2758766B2 true JP2758766B2 (ja) 1998-05-28

Family

ID=24601009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4038746A Expired - Lifetime JP2758766B2 (ja) 1991-01-30 1992-01-29 アンギオテンシンｉｉレセプタをブロツキングする２，３，６置換キナゾリノン類

Country Status (23)

Country Link
US (2) US5290780A (cg-RX-API-DMAC7.html)
EP (1) EP0497150B1 (cg-RX-API-DMAC7.html)
JP (1) JP2758766B2 (cg-RX-API-DMAC7.html)
KR (1) KR920014805A (cg-RX-API-DMAC7.html)
CN (1) CN1037440C (cg-RX-API-DMAC7.html)
AT (1) ATE164158T1 (cg-RX-API-DMAC7.html)
AU (2) AU642573B2 (cg-RX-API-DMAC7.html)
CA (1) CA2060154A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ281429B6 (cg-RX-API-DMAC7.html)
DE (1) DE69224763T2 (cg-RX-API-DMAC7.html)
DK (1) DK0497150T3 (cg-RX-API-DMAC7.html)
ES (1) ES2117014T3 (cg-RX-API-DMAC7.html)
FI (1) FI920217A7 (cg-RX-API-DMAC7.html)
GR (1) GR3026592T3 (cg-RX-API-DMAC7.html)
HU (1) HUT61748A (cg-RX-API-DMAC7.html)
IE (1) IE920142A1 (cg-RX-API-DMAC7.html)
IL (1) IL100711A0 (cg-RX-API-DMAC7.html)
NO (1) NO920298L (cg-RX-API-DMAC7.html)
NZ (1) NZ241343A (cg-RX-API-DMAC7.html)
PL (1) PL293316A1 (cg-RX-API-DMAC7.html)
SK (1) SK279004B6 (cg-RX-API-DMAC7.html)
TW (1) TW282467B (cg-RX-API-DMAC7.html)
ZA (1) ZA92392B (cg-RX-API-DMAC7.html)

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US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
US5385894A (en) * 1991-03-06 1995-01-31 Merck & Co., Inc. Disubstituted 6-aminoquinazolinones
EP0863143A1 (en) * 1993-03-24 1998-09-09 American Home Products Corporation Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists
US5358951A (en) * 1993-04-23 1994-10-25 American Cyanamid Company Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones
US5610301A (en) * 1993-07-01 1997-03-11 American Cyanamid Company Process for the regioselective n-alkylation of quinazolinones
US5342944A (en) * 1993-07-19 1994-08-30 American Cyanamid Company Process for the preparation of 2-alkyl-3,5,6,7- or 8-substituted-4(3H)-quinazolinones
US5338736A (en) * 1993-10-07 1994-08-16 American Cyanamid Company Angiotensin II receptor blocking 2,3,6-substituted quinazolinones
ATE176784T1 (de) * 1994-09-20 1999-03-15 Wakunaga Seiyaku Kk Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
ATE240325T1 (de) * 1995-06-07 2003-05-15 Wyeth Corp Verfahren zur herstellung von biphenylderivaten
US5763608A (en) * 1996-02-05 1998-06-09 Hoechst Celanese Corporation Process for preparing pyrimidine derivatives
US5739330A (en) * 1996-02-05 1998-04-14 Hoechst Celanese Corporation Process for preparing quinazolones
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
GB0223730D0 (en) * 2002-10-11 2002-11-20 Novartis Ag Organic compounds
EP1557023A2 (en) * 2002-10-18 2005-07-27 Koninklijke Philips Electronics N.V. Method and system for metadata protection in tv-anytime
JP2006512315A (ja) * 2002-11-04 2006-04-13 エヌピーエス ファーマスーティカルズ インコーポレイテッド カルシリティックとしてのキナゾリノン化合物
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
KR101129868B1 (ko) * 2006-10-04 2012-04-12 화이자 프로덕츠 인코포레이티드 칼슘 수용체 길항제로서의 피리도［4,3-ｄ］피리미딘-4(3Ｈ)-온 유도체
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN104364239B (zh) 2012-06-13 2017-08-25 霍夫曼-拉罗奇有限公司 二氮杂螺环烷烃和氮杂螺环烷烃
ES2753163T3 (es) 2012-09-25 2020-04-07 Hoffmann La Roche Derivados de hexahidropirrolo[3,4-c]pirrol y compuestos relacionados como inhibidores de la autotaxina (ATX) y como inhibidores de la producción de ácido lisofosfatídico (LPA) para tratar, por ejemplo, enfermedades renales
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
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US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
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JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
SG11201607839UA (en) 2014-03-26 2016-10-28 Hoffmann La Roche Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
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EP3353181B1 (en) 2015-09-24 2021-08-11 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
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JP6877413B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
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Also Published As

Publication number Publication date
EP0497150A1 (en) 1992-08-05
US5405849A (en) 1995-04-11
ES2117014T3 (es) 1998-08-01
ZA92392B (en) 1992-10-28
GR3026592T3 (en) 1998-07-31
AU1039792A (en) 1992-08-06
NZ241343A (en) 1994-06-27
DE69224763D1 (de) 1998-04-23
KR920014805A (ko) 1992-08-25
FI920217L (fi) 1992-07-31
AU642573B2 (en) 1993-10-21
NO920298D0 (no) 1992-01-22
DK0497150T3 (da) 1998-06-02
CN1066847A (zh) 1992-12-09
IE920142A1 (en) 1992-07-29
TW282467B (cg-RX-API-DMAC7.html) 1996-08-01
CS25592A3 (en) 1992-08-12
FI920217A7 (fi) 1992-07-31
FI920217A0 (fi) 1992-01-17
DE69224763T2 (de) 1998-07-09
SK279004B6 (sk) 1998-05-06
EP0497150B1 (en) 1998-03-18
HUT61748A (en) 1993-03-01
AU4490693A (en) 1993-11-18
CZ281429B6 (cs) 1996-09-11
IL100711A0 (en) 1992-09-06
US5290780A (en) 1994-03-01
CA2060154A1 (en) 1992-07-31
JPH0578332A (ja) 1993-03-30
NO920298L (no) 1992-07-31
PL293316A1 (en) 1993-08-23
HU9200278D0 (en) 1992-04-28
ATE164158T1 (de) 1998-04-15
CN1037440C (zh) 1998-02-18
AU647992B2 (en) 1994-03-31

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