JP2744920B2 - マクロサイクリックキレート薬およびそのキレート - Google Patents

マクロサイクリックキレート薬およびそのキレート

Info

Publication number
JP2744920B2
JP2744920B2 JP1500736A JP50073689A JP2744920B2 JP 2744920 B2 JP2744920 B2 JP 2744920B2 JP 1500736 A JP1500736 A JP 1500736A JP 50073689 A JP50073689 A JP 50073689A JP 2744920 B2 JP2744920 B2 JP 2744920B2
Authority
JP
Japan
Prior art keywords
cyclododecane
tetraaza
carboxymethyl
benzyloxy
propionamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1500736A
Other languages
English (en)
Japanese (ja)
Other versions
JPH03501848A (ja
Inventor
エルネスト フェルダー
カルロ ムス
ルチアノ フマガッリ
フルヴィオ ウッジェリ
Original Assignee
ブラッコ インドゥストリア キミカ エッセ ピ ア
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブラッコ インドゥストリア キミカ エッセ ピ ア filed Critical ブラッコ インドゥストリア キミカ エッセ ピ ア
Publication of JPH03501848A publication Critical patent/JPH03501848A/ja
Application granted granted Critical
Publication of JP2744920B2 publication Critical patent/JP2744920B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
JP1500736A 1987-12-24 1988-12-16 マクロサイクリックキレート薬およびそのキレート Expired - Lifetime JP2744920B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT23217A/87 1987-12-24
IT23217/87A IT1224416B (it) 1987-12-24 1987-12-24 Chelanti macrociclici e loro chelati

Publications (2)

Publication Number Publication Date
JPH03501848A JPH03501848A (ja) 1991-04-25
JP2744920B2 true JP2744920B2 (ja) 1998-04-28

Family

ID=11204998

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1500736A Expired - Lifetime JP2744920B2 (ja) 1987-12-24 1988-12-16 マクロサイクリックキレート薬およびそのキレート

Country Status (14)

Country Link
EP (2) EP0440606A1 (de)
JP (1) JP2744920B2 (de)
KR (1) KR900700467A (de)
AT (1) ATE120191T1 (de)
DE (1) DE3853415T2 (de)
ES (1) ES2070845T3 (de)
IE (1) IE67551B1 (de)
IL (1) IL88762A (de)
IT (1) IT1224416B (de)
MX (1) MX9203262A (de)
NZ (1) NZ227421A (de)
PH (1) PH26255A (de)
WO (1) WO1989005802A1 (de)
ZA (1) ZA889597B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE137228T1 (de) * 1987-07-16 1996-05-15 Nycomed Imaging As Aminocarbonsäure und derivate
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US6039931A (en) * 1989-06-30 2000-03-21 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
AU663572B2 (en) * 1992-03-27 1995-10-12 Nihon Medi-Physics Co., Ltd. Tetraazacyclododecane derivative and its use
US5310535A (en) * 1992-04-24 1994-05-10 The Dow Chemical Company Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
EP0588229A3 (en) * 1992-09-12 1994-06-15 Hoechst Ag Macrocyclic chelating agents for the preparation of technetium or rhenium complexes
AU7384394A (en) * 1993-06-30 1995-01-24 Akzo Nobel N.V. Chelating compounds
EP0702677A1 (de) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatische amidverbindungen und seine metallchelate
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1293778B1 (it) * 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
IT1297034B1 (it) 1997-12-30 1999-08-03 Bracco Spa Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
EP0232751B1 (de) * 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-Substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
EP0281474B2 (de) * 1987-02-28 2006-05-24 Sumitomo Electric Industries Limited Verfahren zur Herstellung eines Oxid-Verbindungssupraleiterfadens
EP0505015B1 (de) * 1987-03-13 1997-05-14 Kabushiki Kaisha Toshiba Supraleitender Draht und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
EP0325762B1 (de) 1995-03-22
DE3853415D1 (de) 1995-04-27
PH26255A (en) 1992-04-01
KR900700467A (ko) 1990-08-13
IE67551B1 (en) 1996-04-17
IT1224416B (it) 1990-10-04
EP0325762A1 (de) 1989-08-02
NZ227421A (en) 1990-10-26
JPH03501848A (ja) 1991-04-25
ATE120191T1 (de) 1995-04-15
IL88762A0 (en) 1989-07-31
WO1989005802A1 (en) 1989-06-29
ZA889597B (en) 1989-09-27
IT8723217A0 (it) 1987-12-24
IL88762A (en) 1995-07-31
EP0440606A1 (de) 1991-08-14
ES2070845T3 (es) 1995-06-16
DE3853415T2 (de) 1995-08-31
MX9203262A (es) 1992-07-01
IE883844L (en) 1989-06-24

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