JP2708632B2 - 非感染性血漿の製造法 - Google Patents
非感染性血漿の製造法Info
- Publication number
- JP2708632B2 JP2708632B2 JP3506288A JP50628891A JP2708632B2 JP 2708632 B2 JP2708632 B2 JP 2708632B2 JP 3506288 A JP3506288 A JP 3506288A JP 50628891 A JP50628891 A JP 50628891A JP 2708632 B2 JP2708632 B2 JP 2708632B2
- Authority
- JP
- Japan
- Prior art keywords
- plasma
- lipid
- solid phase
- phase extraction
- tnbp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 8
- 230000002458 infectious effect Effects 0.000 title claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 238000000034 method Methods 0.000 claims abstract description 22
- 150000002632 lipids Chemical class 0.000 claims abstract description 13
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims abstract description 10
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 5
- 239000012071 phase Substances 0.000 claims abstract description 5
- 239000003599 detergent Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 238000005119 centrifugation Methods 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 229920002113 octoxynol Polymers 0.000 claims description 4
- 229940066429 octoxynol Drugs 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- 238000011146 sterile filtration Methods 0.000 claims description 2
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 3
- 210000002381 plasma Anatomy 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 241000700605 Viruses Species 0.000 description 6
- 239000013504 Triton X-100 Substances 0.000 description 5
- 229920004890 Triton X-100 Polymers 0.000 description 5
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- -1 vegetable oil Chemical class 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4008852.9 | 1990-03-20 | ||
| DE4008852A DE4008852A1 (de) | 1990-03-20 | 1990-03-20 | Verfahren zur herstellung von nicht-infektioesem blutplasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04506668A JPH04506668A (ja) | 1992-11-19 |
| JP2708632B2 true JP2708632B2 (ja) | 1998-02-04 |
Family
ID=6402597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3506288A Expired - Lifetime JP2708632B2 (ja) | 1990-03-20 | 1991-03-16 | 非感染性血漿の製造法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0472708B1 (enExample) |
| JP (1) | JP2708632B2 (enExample) |
| AT (1) | ATE110272T1 (enExample) |
| DE (3) | DE4008852A1 (enExample) |
| DK (1) | DK0472708T3 (enExample) |
| ES (1) | ES2059129T3 (enExample) |
| FI (1) | FI101128B (enExample) |
| WO (1) | WO1991014439A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639376A (en) * | 1994-01-10 | 1997-06-17 | Hemasure, Inc. | Process for simultaneously removing leukocytes and methylene blue from plasma |
| WO1995018665A1 (en) * | 1994-01-10 | 1995-07-13 | Hemasure, Inc. | Device and process for removing leukocytes and viral inactivating agents from blood |
| US6136865A (en) * | 1995-05-20 | 2000-10-24 | Octapharma Ag | Method for reduction of the infectiousness of potentially infectious material |
| DE19729778A1 (de) * | 1997-07-11 | 1999-01-21 | Blutspendedienst Der Drk Lande | Verfahren zur Herstellung von virusinaktivierten biologischen Flüssigkeiten |
| EP0896824A1 (en) † | 1997-08-05 | 1999-02-17 | Octapharma Ag | A universally applicable blood plasma |
| US7655252B2 (en) | 1999-04-28 | 2010-02-02 | The Regents Of The University Of Michigan | Antimicrobial nanoemulsion compositions and methods |
| US6635676B2 (en) * | 1999-04-28 | 2003-10-21 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
| JP2010209109A (ja) * | 2001-06-25 | 2010-09-24 | Regents Of The Univ Of Michigan | 抗微生物ナノエマルジョンの組成物および方法 |
| CN1302009C (zh) * | 2005-09-05 | 2007-02-28 | 武汉海特生物制药股份有限公司 | 用有机溶剂病毒灭活法制备鼠神经生长因子的工艺 |
| US8747872B2 (en) | 2007-05-02 | 2014-06-10 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| EP2034010A1 (en) | 2007-08-30 | 2009-03-11 | Omrix Biopharmaceuticals Ltd. | Compositions suitable for repair and/or treatment of injured spinal tissue |
| US9974844B2 (en) | 2008-11-17 | 2018-05-22 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3033932C2 (de) * | 1980-09-10 | 1984-05-24 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Kaltsterilisation von Blutgerinnungsfaktor VIII enthaltenden Präparaten |
| EP0050061B2 (en) * | 1980-10-06 | 1990-06-20 | New York Blood Center, Inc. | Method of reducing undesirable activities of biological and pharmaceutical products |
| US4591505A (en) * | 1982-04-14 | 1986-05-27 | New York Blood Center, Inc. | Process for inactivating hepatitis B virus |
| US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| US4789545A (en) * | 1986-03-31 | 1988-12-06 | New York Blood Center, Inc. | Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof |
| US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
| DE3878245D1 (de) * | 1988-11-05 | 1993-03-18 | Octapharma Ag | Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie. |
-
1990
- 1990-03-20 DE DE4008852A patent/DE4008852A1/de active Granted
- 1990-07-06 DE DE4021542A patent/DE4021542C2/de not_active Expired - Fee Related
-
1991
- 1991-03-16 AT AT91906410T patent/ATE110272T1/de not_active IP Right Cessation
- 1991-03-16 ES ES91906410T patent/ES2059129T3/es not_active Expired - Lifetime
- 1991-03-16 DE DE59102623T patent/DE59102623D1/de not_active Revoked
- 1991-03-16 DK DK91906410.5T patent/DK0472708T3/da active
- 1991-03-16 EP EP91906410A patent/EP0472708B1/de not_active Revoked
- 1991-03-16 JP JP3506288A patent/JP2708632B2/ja not_active Expired - Lifetime
- 1991-03-16 WO PCT/EP1991/000503 patent/WO1991014439A1/de not_active Ceased
- 1991-11-11 FI FI915301A patent/FI101128B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| DE59102623D1 (de) | 1994-09-29 |
| DE4008852C2 (enExample) | 1992-06-17 |
| DE4021542A1 (de) | 1992-01-09 |
| DK0472708T3 (da) | 1994-09-19 |
| DE4021542C2 (de) | 1995-08-17 |
| EP0472708B1 (de) | 1994-08-24 |
| DE4008852A1 (de) | 1991-09-26 |
| ES2059129T3 (es) | 1994-11-01 |
| EP0472708A1 (de) | 1992-03-04 |
| FI915301A0 (fi) | 1991-11-11 |
| JPH04506668A (ja) | 1992-11-19 |
| WO1991014439A1 (de) | 1991-10-03 |
| ATE110272T1 (de) | 1994-09-15 |
| FI101128B (fi) | 1998-04-30 |
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