JP2677588B2 - インダン‐、ジヒドロベンゾフラン‐、ジヒドロベンゾチオフエン‐、及びインドリン‐誘導体、その酸付加塩及びその異性体並びにその製造方法 - Google Patents

インダン‐、ジヒドロベンゾフラン‐、ジヒドロベンゾチオフエン‐、及びインドリン‐誘導体、その酸付加塩及びその異性体並びにその製造方法

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Publication number
JP2677588B2
JP2677588B2 JP63042388A JP4238888A JP2677588B2 JP 2677588 B2 JP2677588 B2 JP 2677588B2 JP 63042388 A JP63042388 A JP 63042388A JP 4238888 A JP4238888 A JP 4238888A JP 2677588 B2 JP2677588 B2 JP 2677588B2
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JP
Japan
Prior art keywords
group
acid
formula
atoms
dihydro
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP63042388A
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English (en)
Japanese (ja)
Other versions
JPS63264557A (ja
Inventor
クラウス・ペーター・ベゲゼ
イエンス・クリステイアン・ペレガード
Original Assignee
ハー・ルンドベック・アクチエゼルスカベット
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Application filed by ハー・ルンドベック・アクチエゼルスカベット filed Critical ハー・ルンドベック・アクチエゼルスカベット
Publication of JPS63264557A publication Critical patent/JPS63264557A/ja
Application granted granted Critical
Publication of JP2677588B2 publication Critical patent/JP2677588B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP63042388A 1987-02-26 1988-02-26 インダン‐、ジヒドロベンゾフラン‐、ジヒドロベンゾチオフエン‐、及びインドリン‐誘導体、その酸付加塩及びその異性体並びにその製造方法 Expired - Lifetime JP2677588B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8704572 1987-02-26
GB878704572A GB8704572D0 (en) 1987-02-26 1987-02-26 Organic compounds

Publications (2)

Publication Number Publication Date
JPS63264557A JPS63264557A (ja) 1988-11-01
JP2677588B2 true JP2677588B2 (ja) 1997-11-17

Family

ID=10613009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63042388A Expired - Lifetime JP2677588B2 (ja) 1987-02-26 1988-02-26 インダン‐、ジヒドロベンゾフラン‐、ジヒドロベンゾチオフエン‐、及びインドリン‐誘導体、その酸付加塩及びその異性体並びにその製造方法

Country Status (18)

Country Link
US (2) US4847254A (de)
EP (1) EP0281261B1 (de)
JP (1) JP2677588B2 (de)
AT (1) ATE75723T1 (de)
AU (1) AU608293B2 (de)
CA (1) CA1338934C (de)
DE (1) DE3870666D1 (de)
DK (1) DK170636B1 (de)
ES (1) ES2037208T3 (de)
FI (1) FI97380C (de)
GB (1) GB8704572D0 (de)
GR (1) GR3004984T3 (de)
IE (1) IE61257B1 (de)
IL (1) IL85342A (de)
NO (1) NO169119C (de)
NZ (1) NZ223440A (de)
PT (1) PT86836B (de)
ZA (1) ZA881217B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006645A1 (en) * 1988-01-15 1989-07-27 Abbott Laboratories 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes
JP2931986B2 (ja) * 1989-02-17 1999-08-09 武田薬品工業株式会社 アラルキルアミン誘導体
ATE121740T1 (de) * 1989-03-22 1995-05-15 Ciba Geigy Ag Neue benzothiopyranylamine.
JPH0318935A (ja) * 1989-06-15 1991-01-28 Hitachi Ltd データリストに対するアクセスの直列化方式
US5500444A (en) * 1989-11-14 1996-03-19 Hoechst Marion Roussel, Inc. Cardioprotective tocopherol analogs
TW199152B (de) * 1990-11-01 1993-02-01 Takeda Pharm Industry Co Ltd
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
DK36291D0 (da) * 1991-03-01 1991-03-01 Lundbeck & Co As H Anvendelse af piperidylsubstituerede indolderivater til behandling af kognitive lidelser
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
EP0550292A1 (de) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tocopherol-Analog zum Gewebeschutz
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
ATE158287T1 (de) * 1992-04-06 1997-10-15 Merrell Pharma Inc Derivate von 2,3-dihydro-2,2,4,6,7-pentaalkyl-5- benzofuranen
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
DK148292D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Forbindelser
DE69328495T2 (de) * 1993-01-12 2001-01-25 Asahi Chemical Ind 2,3-Dihydrobenzofuran Derivate
US5792791A (en) * 1993-01-12 1998-08-11 Asahi Kasei Kogyo Kabushiki Kaisha 2,3-dihydrobenzofuran derivatives
CA2176127A1 (en) * 1993-12-21 1995-06-29 William Henry Walker Lunn Methods for the treatment or prevention of conditions associated with amyloidogenic reptides
AU694212B2 (en) * 1994-04-28 1998-07-16 Merck Sharp & Dohme Limited Benzofuran derivatives as d4 receptor antagonists
WO1996001816A1 (fr) * 1994-07-07 1996-01-25 Asahi Kasei Kogyo Kabushiki Kaisha Nouveau derive de 2,3-dihydrobenzofuranne, son procede de production et son utilisation
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
GB9521347D0 (en) * 1995-10-18 1995-12-20 Merck Sharp & Dohme Therapeutic agents
CA2268164A1 (en) * 1996-10-08 1998-04-16 Yao-Chang Xu New serotonin 5-ht1f agonists
EP0988289A2 (de) * 1997-06-05 2000-03-29 Takeda Pharmaceutical Company Limited Benzofurane und benzothiophene als unterdrücker der neurodegeneration
EP1303502A2 (de) * 2000-07-06 2003-04-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Tetrahydrobenzothiazol-analoge als neuroprotektive mittel
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE623403A (de) * 1962-08-08
US3553093A (en) * 1965-03-19 1971-01-05 Xerox Corp Color photoelectrophoretic imaging process
US3513239A (en) * 1967-03-15 1970-05-19 Smithkline Corp Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith
BE786748A (fr) * 1971-07-26 1973-01-26 Basf Ag 1-aminomethyl-indanes-n-substitues
CH601166A5 (de) * 1974-02-14 1978-06-30 Ciba Geigy Ag
JPS535146A (en) * 1976-07-02 1978-01-18 Tanabe Seiyaku Co Ltd Indane derivatives and their preparation
US4505932A (en) * 1983-05-13 1985-03-19 Abbott Laboratories Method of producing α2 -adrenergic receptor agonist activity
US4777168A (en) * 1984-10-23 1988-10-11 Rorer Pharmaceutical Corporation Bicyclic benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use

Also Published As

Publication number Publication date
FI97380B (fi) 1996-08-30
IE61257B1 (en) 1994-10-19
ATE75723T1 (de) 1992-05-15
DE3870666D1 (de) 1992-06-11
EP0281261A2 (de) 1988-09-07
NO880833L (no) 1988-08-29
GB8704572D0 (en) 1987-04-01
DK170636B1 (da) 1995-11-20
JPS63264557A (ja) 1988-11-01
NO880833D0 (no) 1988-02-25
EP0281261B1 (de) 1992-05-06
US4847254A (en) 1989-07-11
DK91488D0 (da) 1988-02-23
CA1338934C (en) 1997-02-25
DK91488A (da) 1988-08-27
AU608293B2 (en) 1991-03-28
ES2037208T3 (es) 1993-06-16
EP0281261A3 (en) 1989-11-23
NO169119B (no) 1992-02-03
PT86836A (pt) 1988-03-01
AU1216788A (en) 1988-09-01
FI880906A (fi) 1988-08-27
FI880906A0 (fi) 1988-02-26
ZA881217B (en) 1989-01-25
IL85342A (en) 1993-01-14
US4946863A (en) 1990-08-07
NO169119C (no) 1992-05-13
IE880297L (en) 1988-08-26
GR3004984T3 (de) 1993-04-28
FI97380C (fi) 1996-12-10
NZ223440A (en) 1991-02-26
PT86836B (pt) 1992-05-29

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