JP2638600C - - Google Patents
Info
- Publication number
- JP2638600C JP2638600C JP2638600C JP 2638600 C JP2638600 C JP 2638600C JP 2638600 C JP2638600 C JP 2638600C
- Authority
- JP
- Japan
- Prior art keywords
- base material
- antibody
- chamber
- filter
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090001123 antibodies Proteins 0.000 claims description 103
- 102000004965 antibodies Human genes 0.000 claims description 103
- 239000000463 material Substances 0.000 claims description 103
- 239000011159 matrix material Substances 0.000 claims description 43
- 239000003153 chemical reaction reagent Substances 0.000 claims description 37
- 239000000427 antigen Substances 0.000 claims description 34
- 108091007172 antigens Proteins 0.000 claims description 33
- 102000038129 antigens Human genes 0.000 claims description 33
- 239000000126 substance Substances 0.000 claims description 31
- 102000004190 Enzymes Human genes 0.000 claims description 22
- 108090000790 Enzymes Proteins 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 21
- 239000000758 substrate Substances 0.000 claims description 13
- 239000002250 absorbent Substances 0.000 claims description 11
- 230000002745 absorbent Effects 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 229940088597 Hormone Drugs 0.000 claims description 7
- 239000002981 blocking agent Substances 0.000 claims description 7
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- 239000000203 mixture Substances 0.000 claims description 7
- 238000003745 diagnosis Methods 0.000 claims description 3
- 230000002452 interceptive Effects 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 230000001900 immune effect Effects 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims 3
- 230000003111 delayed Effects 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 230000027455 binding Effects 0.000 description 28
- 239000003446 ligand Substances 0.000 description 20
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- 238000001914 filtration Methods 0.000 description 17
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- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 6
- 229940040129 Luteinizing Hormone Drugs 0.000 description 6
- 102000009151 Luteinizing Hormone Human genes 0.000 description 6
- 108010073521 Luteinizing Hormone Proteins 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
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- 102000002260 Alkaline Phosphatase Human genes 0.000 description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 4
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- 239000003814 drug Substances 0.000 description 4
- 229940079593 drugs Drugs 0.000 description 4
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 108010045030 monoclonal antibodies Proteins 0.000 description 4
- 102000005614 monoclonal antibodies Human genes 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- 235000020183 skimmed milk Nutrition 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- JTNGEYANGCBZLK-UHFFFAOYSA-N 1H-indol-3-yl dihydrogen phosphate Chemical compound C1=CC=C2C(OP(O)(=O)O)=CNC2=C1 JTNGEYANGCBZLK-UHFFFAOYSA-N 0.000 description 2
- 108010032595 Antibody Binding Sites Proteins 0.000 description 2
- 240000006497 Dianthus caryophyllus Species 0.000 description 2
- 235000009355 Dianthus caryophyllus Nutrition 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 229940072417 Peroxidase Drugs 0.000 description 2
- 108090000437 Peroxidases Proteins 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 230000036462 Unbound Effects 0.000 description 2
- 210000002700 Urine Anatomy 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 102000005936 beta-Galactosidase Human genes 0.000 description 2
- 108010005774 beta-Galactosidase Proteins 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000004581 coalescence Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000001809 detectable Effects 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 229920005615 natural polymer Polymers 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 230000002829 reduced Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- RDOXTESZEPMUJZ-UHFFFAOYSA-N Anisole Chemical group COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- 229940015047 Chorionic Gonadotropin Drugs 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 210000000987 Immune System Anatomy 0.000 description 1
- 102000018358 Immunoglobulins Human genes 0.000 description 1
- 108060003951 Immunoglobulins Proteins 0.000 description 1
- 241000360168 Masticophis Species 0.000 description 1
- 210000004080 Milk Anatomy 0.000 description 1
- 108020005203 Oxidases Proteins 0.000 description 1
- 239000004698 Polyethylene (PE) Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 240000007742 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 210000003491 Skin Anatomy 0.000 description 1
- IOMLBTHPCVDRHM-UHFFFAOYSA-N [3-[(2,4-dimethylphenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate Chemical compound CC1=CC(C)=CC=C1NC(=O)C1=CC2=CC=CC=C2C=C1OP(O)(O)=O IOMLBTHPCVDRHM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000840 anti-viral Effects 0.000 description 1
- 230000000890 antigenic Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000000975 bioactive Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 230000002860 competitive Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000001419 dependent Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 230000003054 hormonal Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000000984 immunochemical Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000670 limiting Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 238000010397 one-hybrid screening Methods 0.000 description 1
- 239000011238 particulate composite Substances 0.000 description 1
- 230000000149 penetrating Effects 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000023 polynucleotide Polymers 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002285 radioactive Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000003068 static Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Family
ID=
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