JP2539373B2 - キシロ−スイソメラ−ゼの製造方法 - Google Patents
キシロ−スイソメラ−ゼの製造方法Info
- Publication number
- JP2539373B2 JP2539373B2 JP61029175A JP2917586A JP2539373B2 JP 2539373 B2 JP2539373 B2 JP 2539373B2 JP 61029175 A JP61029175 A JP 61029175A JP 2917586 A JP2917586 A JP 2917586A JP 2539373 B2 JP2539373 B2 JP 2539373B2
- Authority
- JP
- Japan
- Prior art keywords
- xylose isomerase
- glucose
- xylose
- isomerase
- strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108700040099 Xylose isomerases Proteins 0.000 title claims abstract description 61
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 37
- 239000008103 glucose Substances 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 21
- 241001468239 Streptomyces murinus Species 0.000 claims abstract description 17
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 36
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 18
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 7
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 7
- 235000005822 corn Nutrition 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 3
- 241000209149 Zea Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 abstract description 15
- 108090000790 Enzymes Proteins 0.000 abstract description 15
- 238000000855 fermentation Methods 0.000 abstract description 15
- 230000004151 fermentation Effects 0.000 abstract description 15
- 238000006317 isomerization reaction Methods 0.000 abstract description 12
- 229930091371 Fructose Natural products 0.000 abstract description 11
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract description 11
- 239000005715 Fructose Substances 0.000 abstract description 11
- 108090000769 Isomerases Proteins 0.000 abstract description 6
- 102000004195 Isomerases Human genes 0.000 abstract description 6
- 238000000746 purification Methods 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 description 21
- 239000006188 syrup Substances 0.000 description 12
- 235000020357 syrup Nutrition 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 241000187747 Streptomyces Species 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 240000008042 Zea mays Species 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229920001983 poloxamer Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 108010058846 Ovalbumin Proteins 0.000 description 2
- 241000218589 Streptomyces olivaceus Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000013587 production medium Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000010802 sludge Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 241000187844 Actinoplanes Species 0.000 description 1
- 240000002900 Arthrospira platensis Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 241000589565 Flavobacterium Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000133261 Scabropezia flavovirens Species 0.000 description 1
- 240000000961 Setaria parviflora Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000187759 Streptomyces albus Species 0.000 description 1
- 241000958242 Streptomyces echinatus Species 0.000 description 1
- 241000187438 Streptomyces fradiae Species 0.000 description 1
- 241001467541 Streptomyces galbus Species 0.000 description 1
- 241000187437 Streptomyces glaucescens Species 0.000 description 1
- 241000946874 Streptomyces matensis Species 0.000 description 1
- 241001454746 Streptomyces niveus Species 0.000 description 1
- 241000187411 Streptomyces phaeochromogenes Species 0.000 description 1
- 241000531819 Streptomyces venezuelae Species 0.000 description 1
- 241000187123 Streptomyces vinaceus Species 0.000 description 1
- 241000970854 Streptomyces violaceusniger Species 0.000 description 1
- 241000187122 Streptomyces virginiae Species 0.000 description 1
- 241000158606 Streptomyces wedmorensis Species 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical group [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 230000012666 negative regulation of transcription by glucose Effects 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK1111/85 | 1985-03-12 | ||
| DK111185A DK111185A (da) | 1985-03-12 | 1985-03-12 | Xyloseisomerase, fremgangsmaade til fremstilling deraf, immobiliseret xyloseisomerase og fremgangsmaade til isomerisering af glucose til fructose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61212285A JPS61212285A (ja) | 1986-09-20 |
| JP2539373B2 true JP2539373B2 (ja) | 1996-10-02 |
Family
ID=8101126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61029175A Expired - Lifetime JP2539373B2 (ja) | 1985-03-12 | 1986-02-14 | キシロ−スイソメラ−ゼの製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4687742A (enExample) |
| EP (1) | EP0194760B1 (enExample) |
| JP (1) | JP2539373B2 (enExample) |
| KR (1) | KR960013132B1 (enExample) |
| AT (1) | ATE66248T1 (enExample) |
| CA (1) | CA1316477C (enExample) |
| DE (1) | DE3680802D1 (enExample) |
| DK (2) | DK111185A (enExample) |
| ES (1) | ES8703523A1 (enExample) |
| HU (1) | HU196841B (enExample) |
| IN (1) | IN161740B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894331A (en) * | 1985-09-27 | 1990-01-16 | Amgen Inc. | Partial marker cassette mutagenesis of xylose isomerase |
| US5047511A (en) * | 1989-08-28 | 1991-09-10 | Pitman-Moore, Inc. | Method for recovering recombinant proteins |
| US5219751A (en) * | 1990-10-19 | 1993-06-15 | Novo Nordisk A/S Novo Alle, | Xylase isomerase purified from thermotoga maritima and thermotoga neapolitana |
| US5268280A (en) * | 1990-10-19 | 1993-12-07 | Novo Nordisk A/S | Method for glucose isomerization using xylose isomerase purified from Thermotoga Maritima and Thermotoga Neapolitana |
| GB9502413D0 (en) * | 1995-02-08 | 1995-03-29 | Primalco Ltd | Xylose isomerase |
| CN1654641A (zh) | 1999-11-10 | 2005-08-17 | 诺维信公司 | Fungamyl样α－淀粉酶变体 |
| JP2002330763A (ja) * | 2001-05-02 | 2002-11-19 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
| CN101981200A (zh) | 2008-03-27 | 2011-02-23 | 诺维信公司 | 从含木素纤维素材料产生发酵产物 |
| US20110165617A1 (en) | 2008-09-30 | 2011-07-07 | Novozymes North America, Inc. | Enzymatic Hydrolysis Of Pretreated Lignocellulose-Containing Material With Distillers Dried Grains |
| ES2667812T3 (es) | 2008-11-20 | 2018-05-14 | Novozymes Inc. | Polipéptidos que tienen actividad potenciadora amilolítica y polinucleótidos que codifican los mismos |
| EP2384365A2 (en) | 2008-12-30 | 2011-11-09 | Novozymes North America, Inc. | Improvement of enzymatic hydrolysis of pretreated lignocellulose-containing material with dissolved air flotation sludge |
| WO2011080155A2 (en) | 2009-12-21 | 2011-07-07 | Novozymes A/S | Method for producing fermentation products from lignocellulose-containing material |
| EP2553111B1 (en) | 2010-03-30 | 2016-05-11 | Novozymes A/S | Methods for enhancing by-products from fermentation processes |
| CN103443281B (zh) | 2010-07-07 | 2016-08-10 | 诺维信北美公司 | 发酵方法 |
| AU2016293487B2 (en) | 2015-07-13 | 2021-07-01 | MARA Renewables Corporation | Enhancing microalgal metabolism of xylose |
| EP4603591A3 (en) | 2017-08-31 | 2025-10-22 | Novozymes A/S | Polypeptides having d-psicose 3-epimerase activity and polynucleotides encoding same |
| WO2025111274A2 (en) | 2023-11-20 | 2025-05-30 | Novozymes A/S | Epimerase variants and polynucleotides encoding same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US29152A (en) * | 1860-07-17 | August friedrich and conrad walter | ||
| NL147477B (nl) * | 1965-05-11 | 1975-10-15 | Agency Ind Science Techn | Werkwijze voor het omzetten van glucose in fructose met behulp van een glucose isomeriserend enzym. |
| US3625828A (en) * | 1969-04-16 | 1971-12-07 | Miles Lab | Process for production of glucose isomerase |
| US3622463A (en) * | 1969-08-11 | 1971-11-23 | Cpc International Inc | Production of extracellular glucose isomerase by streptomyces |
| USRE29152E (en) | 1971-09-17 | 1977-03-15 | Cpc International Inc. | Process for the enzymatic isomerization of dextrose to levulose |
| BE788843A (fr) * | 1971-09-17 | 1973-03-15 | Cpc International Inc | Production de preparations enzymatiques d'isomerase de xylose (dextrose) |
| US3989596A (en) * | 1974-03-28 | 1976-11-02 | R. J. Reynolds Tobacco Company | Aggregate of dried flocculated cells |
| US4137126A (en) * | 1975-05-03 | 1979-01-30 | Givaudan Corporation | Process for preparing glucose isomerase using streptomyces glaucescens mutants |
| JPS5282783A (en) * | 1975-12-27 | 1977-07-11 | Mitsui Seitou Kk | Production of fixed glucose isomeraze |
| US4399222A (en) * | 1979-08-06 | 1983-08-16 | A. E. Staley Manufacturing Company | Carbohydrases from acidophilic streptomyces |
| ES485580A1 (es) * | 1979-10-31 | 1980-08-01 | Espanola Petrol | Procedimiento de obtencion de glucosa-isomerasa |
| US4532208A (en) * | 1983-05-05 | 1985-07-30 | Uop Inc. | Constitutive glucose isomerase producer |
| US4551430A (en) * | 1983-10-27 | 1985-11-05 | Uop Inc. | Constitutive producer of a thermostable glucose isomerase |
| DK152764C (da) * | 1985-06-14 | 1988-10-03 | Novo Industri As | Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt |
-
1985
- 1985-03-12 DK DK111185A patent/DK111185A/da not_active Application Discontinuation
- 1985-03-25 US US06/715,936 patent/US4687742A/en not_active Expired - Lifetime
-
1986
- 1986-01-28 IN IN56/MAS/86A patent/IN161740B/en unknown
- 1986-02-14 JP JP61029175A patent/JP2539373B2/ja not_active Expired - Lifetime
- 1986-02-14 AT AT86301050T patent/ATE66248T1/de not_active IP Right Cessation
- 1986-02-14 DE DE8686301050T patent/DE3680802D1/de not_active Expired - Lifetime
- 1986-02-14 EP EP86301050A patent/EP0194760B1/en not_active Expired - Lifetime
- 1986-02-14 KR KR1019860001030A patent/KR960013132B1/ko not_active Expired - Fee Related
- 1986-02-14 CA CA000501939A patent/CA1316477C/en not_active Expired - Fee Related
- 1986-02-14 ES ES552017A patent/ES8703523A1/es not_active Expired
- 1986-02-14 DK DK071086A patent/DK157886C/da active
- 1986-03-11 HU HU861023A patent/HU196841B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK157886B (da) | 1990-02-26 |
| KR960013132B1 (ko) | 1996-09-30 |
| JPS61212285A (ja) | 1986-09-20 |
| US4687742A (en) | 1987-08-18 |
| ES552017A0 (es) | 1987-02-16 |
| HUT40160A (en) | 1986-11-28 |
| IN161740B (enExample) | 1988-01-30 |
| DK111185D0 (da) | 1985-03-12 |
| DK157886C (da) | 1990-07-30 |
| EP0194760A2 (en) | 1986-09-17 |
| EP0194760A3 (en) | 1988-05-04 |
| KR860007375A (ko) | 1986-10-10 |
| ES8703523A1 (es) | 1987-02-16 |
| DE3680802D1 (de) | 1991-09-19 |
| DK71086D0 (da) | 1986-02-14 |
| ATE66248T1 (de) | 1991-08-15 |
| DK111185A (da) | 1986-09-13 |
| HU196841B (en) | 1989-01-30 |
| DK71086A (da) | 1986-09-13 |
| CA1316477C (en) | 1993-04-20 |
| EP0194760B1 (en) | 1991-08-14 |
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