JP2026048659A5 - - Google Patents
Info
- Publication number
- JP2026048659A5 JP2026048659A5 JP2025195257A JP2025195257A JP2026048659A5 JP 2026048659 A5 JP2026048659 A5 JP 2026048659A5 JP 2025195257 A JP2025195257 A JP 2025195257A JP 2025195257 A JP2025195257 A JP 2025195257A JP 2026048659 A5 JP2026048659 A5 JP 2026048659A5
- Authority
- JP
- Japan
- Prior art keywords
- tau
- mtbr
- seq
- epitope
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962886165P | 2019-08-13 | 2019-08-13 | |
| US62/886,165 | 2019-08-13 | ||
| US202062970950P | 2020-02-06 | 2020-02-06 | |
| US62/970,950 | 2020-02-06 | ||
| US202063044836P | 2020-06-26 | 2020-06-26 | |
| US63/044,836 | 2020-06-26 | ||
| JP2022508907A JP7780200B2 (ja) | 2019-08-13 | 2020-08-13 | Ｍｔｂｒタウアイソフォームを検出する方法およびその使用 |
| PCT/US2020/046224 WO2021030615A1 (en) | 2019-08-13 | 2020-08-13 | Methods to detect mtbr tau isoforms and use thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022508907A Division JP7780200B2 (ja) | 2019-08-13 | 2020-08-13 | Ｍｔｂｒタウアイソフォームを検出する方法およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2026048659A JP2026048659A (ja) | 2026-03-17 |
| JP2026048659A5 true JP2026048659A5 (enExample) | 2026-05-13 |
Family
ID=74570452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022508907A Active JP7780200B2 (ja) | 2019-08-13 | 2020-08-13 | Ｍｔｂｒタウアイソフォームを検出する方法およびその使用 |
| JP2025195257A Pending JP2026048659A (ja) | 2019-08-13 | 2025-11-14 | Ｍｔｂｒタウアイソフォームを検出する方法およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022508907A Active JP7780200B2 (ja) | 2019-08-13 | 2020-08-13 | Ｍｔｂｒタウアイソフォームを検出する方法およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220299527A1 (enExample) |
| EP (1) | EP4013772A4 (enExample) |
| JP (2) | JP7780200B2 (enExample) |
| KR (1) | KR20220062287A (enExample) |
| CN (1) | CN114555631A (enExample) |
| AU (1) | AU2020331020A1 (enExample) |
| CA (1) | CA3147548A1 (enExample) |
| IL (1) | IL290492A (enExample) |
| MX (1) | MX2022001817A (enExample) |
| WO (1) | WO2021030615A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4096694A4 (en) | 2020-01-30 | 2024-01-24 | Prognomiq Inc | LUNG BIOMARKERS AND THEIR METHODS OF USE |
| CN117460954A (zh) * | 2021-03-31 | 2024-01-26 | 华盛顿大学 | 作为tau蛋白病的生物标志物的CSF磷酸化tau和β-淀粉样蛋白概况 |
| US20220328134A1 (en) | 2021-03-31 | 2022-10-13 | PrognomIQ, Inc. | Multi-omic assessment |
| US12387508B2 (en) | 2021-09-10 | 2025-08-12 | PrognomIQ, Inc. | Direct classification of raw biomolecule measurement data |
| AU2022341187A1 (en) | 2021-09-13 | 2024-03-21 | PrognomIQ, Inc. | Enhanced detection and quantitation of biomolecules |
| WO2023220276A1 (en) * | 2022-05-11 | 2023-11-16 | Washington University | METHODS TO DETECT Aβ PROTEOFORMS AND USE THEREOF |
| JP2023175325A (ja) * | 2022-05-30 | 2023-12-12 | 学校法人順天堂 | タウオパチーの鑑別診断法 |
| WO2024107745A1 (en) * | 2022-11-14 | 2024-05-23 | Washington University | Methods to detect csf mtbr-tau and uses thereof |
| CN118896992A (zh) * | 2024-08-30 | 2024-11-05 | 南京质谱医学科技有限公司 | p-Tau217蛋白或其片段的检测方法、试剂盒和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9518101B2 (en) * | 2011-09-19 | 2016-12-13 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease |
| CA2867338A1 (en) | 2012-03-13 | 2013-09-19 | Janssen Alzheimer Immunotherapy | Oligomeric a.beta. in the diagnosis, prognosis, and monitoring of alzheimer's disease |
| WO2013181618A2 (en) * | 2012-05-31 | 2013-12-05 | The Trustees Of Columbia University In The City Of New York | Methods to treat alzheimer's disease using apoe inhibitors |
| JP6345655B2 (ja) * | 2012-07-03 | 2018-06-20 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | タウに対する抗体 |
| WO2014011972A1 (en) * | 2012-07-13 | 2014-01-16 | Bristol-Myers Squibb Company | Tau immunoassay |
| US20150253341A1 (en) * | 2014-02-10 | 2015-09-10 | Merck Sharp & Dohme Corp. | Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry |
| EP3674711A3 (en) | 2014-07-01 | 2020-10-28 | Steven W. Graves | Biomarkers and methods for determining risk factors for alzheimer's disease |
| US10830775B2 (en) * | 2014-09-30 | 2020-11-10 | Washington University | Tau kinetic measurements |
| HRP20210124T1 (hr) * | 2014-11-19 | 2021-03-19 | Axon Neuroscience Se | Humanizirana tau antitijela u alzheimerovoj bolesti |
| EA037092B1 (ru) * | 2015-07-06 | 2021-02-04 | Юсб Биофарма Срл | Тау-связывающие антитела |
| WO2017053739A1 (en) | 2015-09-25 | 2017-03-30 | Steen Judith | Methods and compositions for tauopathy diagnosis and treatment |
| WO2018148593A1 (en) * | 2017-02-10 | 2018-08-16 | C2N Diagnostics, Llc | Methods for measuring concentrations of biomolecules in biofluids |
| CN112166117A (zh) * | 2018-05-03 | 2021-01-01 | 华盛顿大学 | 基于位点特异性tau磷酸化的诊断和治疗方法 |
-
2020
- 2020-08-13 MX MX2022001817A patent/MX2022001817A/es unknown
- 2020-08-13 WO PCT/US2020/046224 patent/WO2021030615A1/en not_active Ceased
- 2020-08-13 EP EP20851647.6A patent/EP4013772A4/en active Pending
- 2020-08-13 CA CA3147548A patent/CA3147548A1/en active Pending
- 2020-08-13 JP JP2022508907A patent/JP7780200B2/ja active Active
- 2020-08-13 KR KR1020227008052A patent/KR20220062287A/ko active Pending
- 2020-08-13 AU AU2020331020A patent/AU2020331020A1/en active Pending
- 2020-08-13 US US17/634,843 patent/US20220299527A1/en active Pending
- 2020-08-13 CN CN202080071700.3A patent/CN114555631A/zh active Pending
-
2022
- 2022-02-09 IL IL290492A patent/IL290492A/en unknown
-
2025
- 2025-11-14 JP JP2025195257A patent/JP2026048659A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sonninen et al. | Metabolic alterations in Parkinson’s disease astrocytes | |
| JP7780200B2 (ja) | Ｍｔｂｒタウアイソフォームを検出する方法およびその使用 | |
| Englund et al. | Sensitive ELISA detection of amyloid‐β protofibrils in biological samples | |
| KR102787585B1 (ko) | 부위-특이적 타우 인산화에 기반한 진단 및 치료 방법 | |
| US20210270847A1 (en) | Protein and peptide biomarkers for traumatic injury to the central nervous system | |
| Lo Cascio et al. | Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities | |
| EP4028040A2 (en) | Biomarkers and treatments of alzheimer's disease and mild cognitive impairment | |
| CN117004588A (zh) | 具有微管蛋白羧肽酶活性的蛋白质的纯化方法及其基于肽的抑制剂 | |
| WO2008042190A2 (en) | Detection of neurodegenerative disease | |
| US20250147049A1 (en) | Methods for detecting csf tau species with stage and progression of alzheimer's disease, and use thereof | |
| Kasai et al. | Utilization of a multiple antigenic peptide as a calibration standard in the BAN50 single antibody sandwich ELISA for Aβ oligomers | |
| AU2007274872A1 (en) | Methods and tools for the therapy of neurodegenerative pathologies | |
| WO2018078018A2 (en) | Detection of hypocretin-1 and -2 | |
| RU2022106278A (ru) | Способы детекции изоформ mtbr-тау и их применение | |
| US20230280357A1 (en) | Csf phosphorylated tau and amyloid beta profiles as biomarkers of tauopathies | |
| EP4619416A1 (en) | Methods to detect csf mtbr-tau and uses thereof | |
| US20240124883A1 (en) | Dna aptamers and compositions targeting alpha-synuclein and methods of making and using same | |
| HK40130133A (zh) | 检测csf mtbr-tau的方法及其用途 | |
| Lapcinski et al. | The β-amyloid oligomer Aβ* 56 is associated with Alzheimer’s dementia independently of amyloid pathology | |
| CN117355750A (zh) | 检测阿尔茨海默病阶段和进展的csf tau物质的方法及其用途 | |
| Ismail | Development and utilization of Luminex biomarker assays for diagnosis and monitoring of neurodegenerative disease | |
| Dobson | Development of a Cell Culture Model to Investigate Aluminium's Neurotoxicity, and Putative Role in Alzheimer's Disease |