MX2022001817A - Metodos para detectar isoformas de la region de union a microtubulos (mtbr) tau y uso de las mismas. - Google Patents
Metodos para detectar isoformas de la region de union a microtubulos (mtbr) tau y uso de las mismas.Info
- Publication number
- MX2022001817A MX2022001817A MX2022001817A MX2022001817A MX2022001817A MX 2022001817 A MX2022001817 A MX 2022001817A MX 2022001817 A MX2022001817 A MX 2022001817A MX 2022001817 A MX2022001817 A MX 2022001817A MX 2022001817 A MX2022001817 A MX 2022001817A
- Authority
- MX
- Mexico
- Prior art keywords
- mtbr
- tau species
- detect
- methods
- blood
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
Los métodos descritos en la presente emplean combinaciones únicas de pasos de procesamiento que transforman una muestra de sangre o CSF en una muestra adecuada para cuantificar especies de MTBR tau, así como otras especies de tau. La presente descripción también abarca el uso de especies de MTBR tau en sangre o CSF para medir características patológicas y/o síntomas clínicos de tauopatías de 3R y 4R a fin de diagnosticar, graduar, y/o elegir tratamientos apropiados para una etapa de enfermedad determinada, y modificar un régimen de tratamiento determinado.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962886165P | 2019-08-13 | 2019-08-13 | |
US202062970950P | 2020-02-06 | 2020-02-06 | |
US202063044836P | 2020-06-26 | 2020-06-26 | |
PCT/US2020/046224 WO2021030615A1 (en) | 2019-08-13 | 2020-08-13 | Methods to detect mtbr tau isoforms and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022001817A true MX2022001817A (es) | 2022-03-11 |
Family
ID=74570452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022001817A MX2022001817A (es) | 2019-08-13 | 2020-08-13 | Metodos para detectar isoformas de la region de union a microtubulos (mtbr) tau y uso de las mismas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220299527A1 (es) |
EP (1) | EP4013772A4 (es) |
JP (1) | JP2022544514A (es) |
KR (1) | KR20220062287A (es) |
CN (1) | CN114555631A (es) |
AU (1) | AU2020331020A1 (es) |
CA (1) | CA3147548A1 (es) |
IL (1) | IL290492A (es) |
MX (1) | MX2022001817A (es) |
WO (1) | WO2021030615A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4096694A4 (en) | 2020-01-30 | 2024-01-24 | Prognomiq Inc | LUNG BIOMARKERS AND METHODS OF USE THEREOF |
WO2022212756A1 (en) * | 2021-03-31 | 2022-10-06 | Washington University | Csf phosphorylated tau and amyloid beta profiles as biomarkers of tauopathies |
CA3231038A1 (en) * | 2021-09-13 | 2023-03-16 | Bruce Wilcox | Enhanced detection and quantitation of biomolecules |
WO2023220276A1 (en) * | 2022-05-11 | 2023-11-16 | Washington University | METHODS TO DETECT Aβ PROTEOFORMS AND USE THEREOF |
WO2024107745A1 (en) * | 2022-11-14 | 2024-05-23 | Washington University | Methods to detect csf mtbr-tau and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9518101B2 (en) * | 2011-09-19 | 2016-12-13 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease |
US20150337030A1 (en) * | 2012-05-31 | 2015-11-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat alzheimer's disease using apoe inhibitors |
KR20150036346A (ko) * | 2012-07-03 | 2015-04-07 | 워싱턴 유니버시티 | Tau에 대한 항체 |
WO2014011972A1 (en) * | 2012-07-13 | 2014-01-16 | Bristol-Myers Squibb Company | Tau immunoassay |
US20150253341A1 (en) * | 2014-02-10 | 2015-09-10 | Merck Sharp & Dohme Corp. | Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry |
US10830775B2 (en) * | 2014-09-30 | 2020-11-10 | Washington University | Tau kinetic measurements |
EA037092B1 (ru) * | 2015-07-06 | 2021-02-04 | Юсб Биофарма Срл | Тау-связывающие антитела |
WO2018148593A1 (en) * | 2017-02-10 | 2018-08-16 | C2N Diagnostics, Llc | Methods for measuring concentrations of biomolecules in biofluids |
BR112020021782A2 (pt) * | 2018-05-03 | 2021-02-23 | Washington University | métodos de diagnóstico e tratamento com base em fosforilação de tau específica de sítio |
-
2020
- 2020-08-13 KR KR1020227008052A patent/KR20220062287A/ko unknown
- 2020-08-13 WO PCT/US2020/046224 patent/WO2021030615A1/en unknown
- 2020-08-13 EP EP20851647.6A patent/EP4013772A4/en active Pending
- 2020-08-13 US US17/634,843 patent/US20220299527A1/en active Pending
- 2020-08-13 CN CN202080071700.3A patent/CN114555631A/zh active Pending
- 2020-08-13 CA CA3147548A patent/CA3147548A1/en active Pending
- 2020-08-13 MX MX2022001817A patent/MX2022001817A/es unknown
- 2020-08-13 JP JP2022508907A patent/JP2022544514A/ja active Pending
- 2020-08-13 AU AU2020331020A patent/AU2020331020A1/en active Pending
-
2022
- 2022-02-09 IL IL290492A patent/IL290492A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20220299527A1 (en) | 2022-09-22 |
EP4013772A4 (en) | 2024-06-05 |
AU2020331020A1 (en) | 2022-03-03 |
KR20220062287A (ko) | 2022-05-16 |
JP2022544514A (ja) | 2022-10-19 |
CA3147548A1 (en) | 2021-02-18 |
EP4013772A1 (en) | 2022-06-22 |
CN114555631A (zh) | 2022-05-27 |
WO2021030615A1 (en) | 2021-02-18 |
IL290492A (en) | 2022-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022001817A (es) | Metodos para detectar isoformas de la region de union a microtubulos (mtbr) tau y uso de las mismas. | |
Chuang et al. | Migraine and risk of dementia: a nationwide retrospective cohort study | |
MX2018008421A (es) | Métodos para tratar cáncer y el uso de biomarcadores como predictor de sensibilidad clínica a terapias. | |
GB2463401B (en) | Characterizing prostate disorders by analysis of microvesicles | |
WO2015153864A3 (en) | Methods for treating inflammatory conditions | |
Degerman Gunnarsson et al. | High tau levels in cerebrospinal fluid predict rapid decline and increased dementia mortality in Alzheimer's disease | |
FR3060755B1 (fr) | Methode de diagnostic d'une peau presentant des signes de secheresse | |
Rosén et al. | Cerebrospinal fluid biomarkers in cardiac arrest survivors | |
NZ729773A (en) | Biomarkers for disease progression in melanoma | |
WO2018026969A3 (en) | Plazomicin antibodies and methods of use | |
CA2991055A1 (en) | Diagnostic test for alzheimer's disease based on identification of a proteolytic pathway | |
WO2014197460A8 (en) | Methods for diagnosing and treating bicuspid aortic valve and/or aortopathies | |
GB2569932A (en) | Identification and use of very long chain dicarboxylic acids for disease diagnosis, chemoprevention, and treatment | |
BR112022003686A2 (pt) | Tratamento de sintomas induzidos pelo ciclo menstrual | |
WO2020178447A8 (en) | Method for determining efficacy | |
BR112014007947A2 (pt) | método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5 | |
MY179665A (en) | In vitro diagnostic method for alzhemer's disease based on the albumin redox level in the cerebrospinal fluid | |
MX2023008614A (es) | Metodos para detectar especies de csf tau con estado y progresion de la enfermedad de alzheimer, y uso de los mismos. | |
Nguyen et al. | 22: Kidney knowledge survey: A validation study in Vietnamese language | |
WO2010093214A3 (en) | Monoclonal antibody recognizing scye1 and use thereof | |
RU2014128849A (ru) | Способ диагностики гастроэзофагельной рефлюксной болезни у детей | |
권병욱 et al. | Association between Serum Vitamin D Level and Albuminuria in Korean Adults: Data from 2013 Korean National Health and Nutrition Examination Survey | |
Hendrickson et al. | A42 ARDS: RISK, TREATMENT, AND OUTCOMES: Higher Total Protein Concentration In Early Mini-Bal In Ards Predicts Improved Clinical Outcomes | |
EA201900091A1 (ru) | Способ диагностики кандидозного стоматита | |
Dessein et al. | FRI0093 The Framingham Score is a Useful Surrogate Marker of High Risk Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |