JP2025514731A - エンテロコッカス・フェカリスワクチンおよびその使用 - Google Patents

エンテロコッカス・フェカリスワクチンおよびその使用 Download PDF

Info

Publication number
JP2025514731A
JP2025514731A JP2024561639A JP2024561639A JP2025514731A JP 2025514731 A JP2025514731 A JP 2025514731A JP 2024561639 A JP2024561639 A JP 2024561639A JP 2024561639 A JP2024561639 A JP 2024561639A JP 2025514731 A JP2025514731 A JP 2025514731A
Authority
JP
Japan
Prior art keywords
polypeptide antigen
seq
recombinant
faecalis
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024561639A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025514731A5 (https=
Inventor
シー フェアマン，ジェファリー
エム バージェス，エイミー
エイ セドラ，アンジー
エイ レモス，ホセ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaxcyte Inc
Original Assignee
Vaxcyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaxcyte Inc filed Critical Vaxcyte Inc
Publication of JP2025514731A publication Critical patent/JP2025514731A/ja
Publication of JP2025514731A5 publication Critical patent/JP2025514731A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1275—Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
JP2024561639A 2022-04-18 2023-04-18 エンテロコッカス・フェカリスワクチンおよびその使用 Pending JP2025514731A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263332110P 2022-04-18 2022-04-18
US63/332,110 2022-04-18
PCT/US2023/065878 WO2023205627A1 (en) 2022-04-18 2023-04-18 Enterococcus faecalis vaccine and uses thereof

Publications (2)

Publication Number Publication Date
JP2025514731A true JP2025514731A (ja) 2025-05-09
JP2025514731A5 JP2025514731A5 (https=) 2026-04-27

Family

ID=88420684

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024561639A Pending JP2025514731A (ja) 2022-04-18 2023-04-18 エンテロコッカス・フェカリスワクチンおよびその使用

Country Status (7)

Country Link
US (1) US20250269004A1 (https=)
EP (1) EP4511060A1 (https=)
JP (1) JP2025514731A (https=)
KR (1) KR20250004816A (https=)
AU (1) AU2023258011A1 (https=)
TW (1) TW202404628A (https=)
WO (1) WO2023205627A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102023131065A1 (de) * 2023-11-09 2025-05-15 Consiglio Nazionale Delle Ricerche Hochstabile Antigen-präsentierende Fusionsproteine und deren Verwendung als Impfstoffkomponenten für die Therapie und/oder Prophylaxe von pathogenen Bakterien

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2289116A1 (en) * 1997-05-06 1998-11-12 Human Genome Sciences, Inc. Enterococcus faecalis polynucleotides and polypeptides
US6617156B1 (en) * 1997-08-15 2003-09-09 Lynn A. Doucette-Stamm Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics
EP1177203B1 (en) * 1999-05-10 2011-10-05 The Texas A&M University System Collagen-binding proteins from enterococcal bacteria
US9839682B2 (en) * 2014-09-12 2017-12-12 Washington University Compositions and methods for the treatment and prevention of Ebp pilus-related diseases

Also Published As

Publication number Publication date
AU2023258011A1 (en) 2024-10-31
TW202404628A (zh) 2024-02-01
WO2023205627A1 (en) 2023-10-26
EP4511060A1 (en) 2025-02-26
US20250269004A1 (en) 2025-08-28
KR20250004816A (ko) 2025-01-08

Similar Documents

Publication Publication Date Title
CN101018863B (zh) 突变体肺炎链球菌溶血素蛋白质
KR20090019007A (ko) 스타필로코쿠스 감염증을 치료 및 예방하기 위한 알파-독소의 용도
CN101132810A (zh) 含有肽聚糖的糖缀合物疫苗
US12115215B2 (en) Composition and method for generating immunity to borrelia burgdorferi
CN106103469B (zh) 突变型葡萄球菌抗原
TW200526244A (en) Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability
US8741302B2 (en) Polypeptide derived from Enterococcus and its use for vaccination
JP2021514387A (ja) ブドウ球菌抗原を含む免疫原性組成物
WO2005108419A1 (en) Mutant cholesterol-binding cytolysin proteins
JP2024540918A (ja) リポ多糖（ｌｐｓ）欠損アシネトバクター・バウマニ多価ワクチン
US20250269004A1 (en) Enterococcus faecalis vaccine and uses thereof
CA3248847A1 (en) CHIMERA POLYPEPTIDES
AU2006287077A1 (en) Streptococcus suis polypeptides and polynucleotides encoding same and their use in vaccinal and diagnostic applications
BE1024282B1 (fr) Compositions immunogènes
US11278609B2 (en) Polypeptides derived from Enterococcus and their use for vaccination and the generation of therapeutic antibodies
KR20070001274A (ko) 치료학적 펩타이드
CN114585381A (zh) 免疫原性组合物
JP2024041903A (ja) 複合糖質ワクチン
WO2023081861A9 (en) Enhanced expression via autotransporters
WO2026060236A1 (en) Compositions and methods for preventing infection
KR20250103717A (ko) 수막염균의 돌연변이된 인자 H 결합 단백질(fHbp), 그의 조성물 및 그의 용도

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260417

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20260417