TW202404628A - 糞腸球菌(enterococcus faecalis)疫苗及其用途 - Google Patents

糞腸球菌(enterococcus faecalis)疫苗及其用途 Download PDF

Info

Publication number
TW202404628A
TW202404628A TW112114427A TW112114427A TW202404628A TW 202404628 A TW202404628 A TW 202404628A TW 112114427 A TW112114427 A TW 112114427A TW 112114427 A TW112114427 A TW 112114427A TW 202404628 A TW202404628 A TW 202404628A
Authority
TW
Taiwan
Prior art keywords
polypeptide antigen
seq
recombinant
amino acid
acid sequence
Prior art date
Application number
TW112114427A
Other languages
English (en)
Chinese (zh)
Inventor
杰弗里 Ｃ 費爾曼
艾姆 Ｍ 伯格斯
安吉 Ａ 塞德拉
何塞 Ａ 萊莫斯
Original Assignee
美商Ｖａｘｃｙｔｅ公司
美國佛羅里達大學研究基金會公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商Ｖａｘｃｙｔｅ公司, 美國佛羅里達大學研究基金會公司 filed Critical 美商Ｖａｘｃｙｔｅ公司
Publication of TW202404628A publication Critical patent/TW202404628A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1275—Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
TW112114427A 2022-04-18 2023-04-18 糞腸球菌(enterococcus faecalis)疫苗及其用途 TW202404628A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263332110P 2022-04-18 2022-04-18
US63/332,110 2022-04-18

Publications (1)

Publication Number Publication Date
TW202404628A true TW202404628A (zh) 2024-02-01

Family

ID=88420684

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112114427A TW202404628A (zh) 2022-04-18 2023-04-18 糞腸球菌(enterococcus faecalis)疫苗及其用途

Country Status (7)

Country Link
US (1) US20250269004A1 (https=)
EP (1) EP4511060A1 (https=)
JP (1) JP2025514731A (https=)
KR (1) KR20250004816A (https=)
AU (1) AU2023258011A1 (https=)
TW (1) TW202404628A (https=)
WO (1) WO2023205627A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102023131065A1 (de) * 2023-11-09 2025-05-15 Consiglio Nazionale Delle Ricerche Hochstabile Antigen-präsentierende Fusionsproteine und deren Verwendung als Impfstoffkomponenten für die Therapie und/oder Prophylaxe von pathogenen Bakterien

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2289116A1 (en) * 1997-05-06 1998-11-12 Human Genome Sciences, Inc. Enterococcus faecalis polynucleotides and polypeptides
US6617156B1 (en) * 1997-08-15 2003-09-09 Lynn A. Doucette-Stamm Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics
EP1177203B1 (en) * 1999-05-10 2011-10-05 The Texas A&M University System Collagen-binding proteins from enterococcal bacteria
US9839682B2 (en) * 2014-09-12 2017-12-12 Washington University Compositions and methods for the treatment and prevention of Ebp pilus-related diseases

Also Published As

Publication number Publication date
AU2023258011A1 (en) 2024-10-31
WO2023205627A1 (en) 2023-10-26
EP4511060A1 (en) 2025-02-26
JP2025514731A (ja) 2025-05-09
US20250269004A1 (en) 2025-08-28
KR20250004816A (ko) 2025-01-08

Similar Documents

Publication Publication Date Title
US9724402B2 (en) Neisseria meningitidis composition and methods thereof
KR20130093084A (ko) 단백질 Ａ(ＳｐＡ) 변이체와 관련된 조성물 및 방법
KR20090019007A (ko) 스타필로코쿠스 감염증을 치료 및 예방하기 위한 알파-독소의 용도
US10196429B2 (en) Neisseria meningitidis composition and methods thereof
CN106103469B (zh) 突变型葡萄球菌抗原
JP2008523142A (ja) ペプチドグリカンを含有する複合糖質ワクチン
AU2019221496B2 (en) Immunogenic composition comprising staphylococcal antigens
TW200526244A (en) Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability
US20240415948A1 (en) Meningococcal b recombinant vaccine
JP2024540918A (ja) リポ多糖（ｌｐｓ）欠損アシネトバクター・バウマニ多価ワクチン
US8741302B2 (en) Polypeptide derived from Enterococcus and its use for vaccination
US20250269004A1 (en) Enterococcus faecalis vaccine and uses thereof
BE1024282B1 (fr) Compositions immunogènes
CN119698291A (zh) 针对脑膜炎奈瑟菌b的佐剂化免疫原性组合物
US20220395566A1 (en) Immunogenic composition
WO2023232807A1 (en) Immunogenic composition
US20170087239A1 (en) Polypeptides Derived from Enterococcus and Their Use for Vaccination and the Generation of Therapeutic Antibodies
JP2024041903A (ja) 複合糖質ワクチン
HK40117919A (zh) 包含缀合荚膜糖抗原的免疫原性组合物及其用途
Douthett Enhancement of the humoral immune response to Pseudomonas aeruginosa flagellin