JP2025513850A5 - - Google Patents
Info
- Publication number
- JP2025513850A5 JP2025513850A5 JP2024560404A JP2024560404A JP2025513850A5 JP 2025513850 A5 JP2025513850 A5 JP 2025513850A5 JP 2024560404 A JP2024560404 A JP 2024560404A JP 2024560404 A JP2024560404 A JP 2024560404A JP 2025513850 A5 JP2025513850 A5 JP 2025513850A5
- Authority
- JP
- Japan
- Prior art keywords
- capsid
- irak
- pharmaceutical composition
- aav
- viral vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263330239P | 2022-04-12 | 2022-04-12 | |
| US63/330,239 | 2022-04-12 | ||
| PCT/US2023/065687 WO2023201272A1 (en) | 2022-04-12 | 2023-04-12 | Use of irak4 modulators for gene therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025513850A JP2025513850A (ja) | 2025-04-30 |
| JP2025513850A5 true JP2025513850A5 (https=) | 2026-04-20 |
Family
ID=86329443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024560404A Pending JP2025513850A (ja) | 2022-04-12 | 2023-04-12 | 遺伝子治療のためのｉｒａｋ４モジュレーターの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230405151A1 (https=) |
| EP (1) | EP4508225A1 (https=) |
| JP (1) | JP2025513850A (https=) |
| KR (1) | KR20250004740A (https=) |
| CN (1) | CN119630802A (https=) |
| AU (1) | AU2023252915A1 (https=) |
| CA (1) | CA3248481A1 (https=) |
| IL (1) | IL316231A (https=) |
| MX (1) | MX2024012616A (https=) |
| TW (1) | TW202400250A (https=) |
| WO (1) | WO2023201272A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0931158A1 (en) | 1996-09-06 | 1999-07-28 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| CA2379166C (en) | 1999-08-09 | 2013-03-26 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs |
| US6818419B2 (en) | 2000-01-13 | 2004-11-16 | Tularik Inc. | IRAK-4: compositions and methods of use |
| ATE318923T1 (de) | 2000-06-01 | 2006-03-15 | Univ North Carolina | Doppelsträngige parvovirus-vektoren |
| US7510872B2 (en) | 2003-02-26 | 2009-03-31 | Nationwide Children's Hospital | Recombinant adeno-associated virus production |
| US7261544B2 (en) | 2003-05-21 | 2007-08-28 | Genzyme Corporation | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids |
| US20100279316A1 (en) | 2007-01-19 | 2010-11-04 | Leonid Gorelik | Antibodies to Phosphorylated IRAK4 |
| KR20180000341A (ko) | 2009-06-16 | 2018-01-02 | 젠자임 코포레이션 | 재조합 ａａｖ 벡터에 대한 개선된 정제 방법 |
| US20110070241A1 (en) * | 2009-06-30 | 2011-03-24 | Duke University | Methods for modulating immune responses to aav gene therapy vectors |
| EP2561073B1 (en) | 2010-04-23 | 2016-08-24 | University of Massachusetts | Cns targeting aav vectors and methods of use thereof |
| KR20160145803A (ko) | 2014-04-22 | 2016-12-20 | 님버스 아이리스 인코포레이티드 | Irak 억제제 및 이의 용도 |
| EP3200788B1 (en) | 2014-09-30 | 2019-09-18 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| WO2016144847A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrrolopyridazine inhibitors of irak4 activity |
| WO2017004133A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN108024971A (zh) | 2015-07-15 | 2018-05-11 | 奥列基因发现技术有限公司 | 作为irak-4抑制剂的取代的氮杂化合物 |
| KR102110573B1 (ko) | 2015-08-13 | 2020-05-13 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Irak4억제제 및 이의 용도 |
| ES2946001T3 (es) | 2016-10-26 | 2023-07-11 | Rigel Pharmaceuticals Inc | Compuestos de pirazol amida como inhibidores de IRAK |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US11542251B2 (en) | 2018-02-14 | 2023-01-03 | Dana-Farber Cancer Institute, Inc. | IRAK degraders and uses thereof |
| IL277408B2 (en) | 2018-04-05 | 2024-08-01 | Merck Patent Gmbh | Heteroaryl compounds as IRAK type II inhibitors and their use |
| US12060366B2 (en) | 2018-06-29 | 2024-08-13 | Dana-Farber Cancer Institute, Inc. | Bispecific degraders |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2020264490A1 (en) | 2019-06-28 | 2020-12-30 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
| WO2021168197A1 (en) | 2020-02-19 | 2021-08-26 | Nurix Therapeutics, Inc. | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
| EP4149622A4 (en) * | 2020-05-12 | 2024-12-18 | Myogene Bio LLC | IMMUNOSUPPRESSIVE AGENTS AND METHODS OF RE-DOSING VIRAL ADMINISTRATION FOR GENE THERAPY |
| US20230250110A1 (en) | 2020-06-03 | 2023-08-10 | Kymera Therapeutics, Inc. | Deuterated irak degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
-
2023
- 2023-04-12 JP JP2024560404A patent/JP2025513850A/ja active Pending
- 2023-04-12 EP EP23722239.3A patent/EP4508225A1/en active Pending
- 2023-04-12 AU AU2023252915A patent/AU2023252915A1/en active Pending
- 2023-04-12 WO PCT/US2023/065687 patent/WO2023201272A1/en not_active Ceased
- 2023-04-12 IL IL316231A patent/IL316231A/en unknown
- 2023-04-12 CN CN202380043587.1A patent/CN119630802A/zh active Pending
- 2023-04-12 KR KR1020247037276A patent/KR20250004740A/ko active Pending
- 2023-04-12 US US18/299,632 patent/US20230405151A1/en active Pending
- 2023-04-12 CA CA3248481A patent/CA3248481A1/en active Pending
- 2023-04-12 TW TW112113694A patent/TW202400250A/zh unknown
-
2024
- 2024-10-10 MX MX2024012616A patent/MX2024012616A/es unknown
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