AU2023252915A1 - Use of irak4 modulators for gene therapy - Google Patents
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- AU2023252915A1 AU2023252915A1 AU2023252915A AU2023252915A AU2023252915A1 AU 2023252915 A1 AU2023252915 A1 AU 2023252915A1 AU 2023252915 A AU2023252915 A AU 2023252915A AU 2023252915 A AU2023252915 A AU 2023252915A AU 2023252915 A1 AU2023252915 A1 AU 2023252915A1
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Applications Claiming Priority (3)
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| US202263330239P | 2022-04-12 | 2022-04-12 | |
| US63/330,239 | 2022-04-12 | ||
| PCT/US2023/065687 WO2023201272A1 (en) | 2022-04-12 | 2023-04-12 | Use of irak4 modulators for gene therapy |
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| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
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| EP0931158A1 (en) | 1996-09-06 | 1999-07-28 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| CA2379166C (en) | 1999-08-09 | 2013-03-26 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs |
| US6818419B2 (en) | 2000-01-13 | 2004-11-16 | Tularik Inc. | IRAK-4: compositions and methods of use |
| ATE318923T1 (de) | 2000-06-01 | 2006-03-15 | Univ North Carolina | Doppelsträngige parvovirus-vektoren |
| US7510872B2 (en) | 2003-02-26 | 2009-03-31 | Nationwide Children's Hospital | Recombinant adeno-associated virus production |
| US7261544B2 (en) | 2003-05-21 | 2007-08-28 | Genzyme Corporation | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids |
| US20100279316A1 (en) | 2007-01-19 | 2010-11-04 | Leonid Gorelik | Antibodies to Phosphorylated IRAK4 |
| KR20180000341A (ko) | 2009-06-16 | 2018-01-02 | 젠자임 코포레이션 | 재조합 aav 벡터에 대한 개선된 정제 방법 |
| US20110070241A1 (en) * | 2009-06-30 | 2011-03-24 | Duke University | Methods for modulating immune responses to aav gene therapy vectors |
| EP2561073B1 (en) | 2010-04-23 | 2016-08-24 | University of Massachusetts | Cns targeting aav vectors and methods of use thereof |
| KR20160145803A (ko) | 2014-04-22 | 2016-12-20 | 님버스 아이리스 인코포레이티드 | Irak 억제제 및 이의 용도 |
| EP3200788B1 (en) | 2014-09-30 | 2019-09-18 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| WO2016144847A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrrolopyridazine inhibitors of irak4 activity |
| WO2017004133A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN108024971A (zh) | 2015-07-15 | 2018-05-11 | 奥列基因发现技术有限公司 | 作为irak-4抑制剂的取代的氮杂化合物 |
| KR102110573B1 (ko) | 2015-08-13 | 2020-05-13 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Irak4억제제 및 이의 용도 |
| ES2946001T3 (es) | 2016-10-26 | 2023-07-11 | Rigel Pharmaceuticals Inc | Compuestos de pirazol amida como inhibidores de IRAK |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
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| IL277408B2 (en) | 2018-04-05 | 2024-08-01 | Merck Patent Gmbh | Heteroaryl compounds as IRAK type II inhibitors and their use |
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| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
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| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
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2023
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- 2023-04-12 EP EP23722239.3A patent/EP4508225A1/en active Pending
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- 2023-04-12 WO PCT/US2023/065687 patent/WO2023201272A1/en not_active Ceased
- 2023-04-12 IL IL316231A patent/IL316231A/en unknown
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- 2023-04-12 TW TW112113694A patent/TW202400250A/zh unknown
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2024
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| IL316231A (en) | 2024-12-01 |
| CN119630802A (zh) | 2025-03-14 |
| WO2023201272A1 (en) | 2023-10-19 |
| CA3248481A1 (en) | 2023-10-19 |
| JP2025513850A (ja) | 2025-04-30 |
| KR20250004740A (ko) | 2025-01-08 |
| MX2024012616A (es) | 2025-02-10 |
| TW202400250A (zh) | 2024-01-01 |
| EP4508225A1 (en) | 2025-02-19 |
| US20230405151A1 (en) | 2023-12-21 |
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