JP2025513850A5 - - Google Patents
Info
- Publication number
- JP2025513850A5 JP2025513850A5 JP2024560404A JP2024560404A JP2025513850A5 JP 2025513850 A5 JP2025513850 A5 JP 2025513850A5 JP 2024560404 A JP2024560404 A JP 2024560404A JP 2024560404 A JP2024560404 A JP 2024560404A JP 2025513850 A5 JP2025513850 A5 JP 2025513850A5
- Authority
- JP
- Japan
- Prior art keywords
- capsid
- irak
- pharmaceutical composition
- aav
- viral vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263330239P | 2022-04-12 | 2022-04-12 | |
| US63/330,239 | 2022-04-12 | ||
| PCT/US2023/065687 WO2023201272A1 (en) | 2022-04-12 | 2023-04-12 | Use of irak4 modulators for gene therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025513850A JP2025513850A (ja) | 2025-04-30 |
| JP2025513850A5 true JP2025513850A5 (OSRAM) | 2026-04-20 |
Family
ID=86329443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024560404A Pending JP2025513850A (ja) | 2022-04-12 | 2023-04-12 | 遺伝子治療のためのｉｒａｋ４モジュレーターの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230405151A1 (OSRAM) |
| EP (1) | EP4508225A1 (OSRAM) |
| JP (1) | JP2025513850A (OSRAM) |
| KR (1) | KR20250004740A (OSRAM) |
| CN (1) | CN119630802A (OSRAM) |
| AU (1) | AU2023252915A1 (OSRAM) |
| CA (1) | CA3248481A1 (OSRAM) |
| IL (1) | IL316231A (OSRAM) |
| MX (1) | MX2024012616A (OSRAM) |
| TW (1) | TW202400250A (OSRAM) |
| WO (1) | WO2023201272A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112021026517A2 (pt) | 2019-06-28 | 2022-05-10 | Kymera Therapeutics Inc | Degradadores de irak e usos dos mesmos |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| EP4072591A4 (en) | 2019-12-10 | 2024-06-05 | Kymera Therapeutics, Inc. | IRAQ DEGRADER AND USES THEREOF |
| JP2023509366A (ja) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001500015A (ja) | 1996-09-06 | 2001-01-09 | トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Ｔ７ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法 |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| EP2369002A1 (en) | 1999-08-09 | 2011-09-28 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs |
| US6818419B2 (en) | 2000-01-13 | 2004-11-16 | Tularik Inc. | IRAK-4: compositions and methods of use |
| ATE318923T1 (de) | 2000-06-01 | 2006-03-15 | Univ North Carolina | Doppelsträngige parvovirus-vektoren |
| WO2004075861A2 (en) | 2003-02-26 | 2004-09-10 | Children's Hospital, Inc. | Recombinant adeno-associated virus production |
| US7261544B2 (en) | 2003-05-21 | 2007-08-28 | Genzyme Corporation | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids |
| US20100279316A1 (en) | 2007-01-19 | 2010-11-04 | Leonid Gorelik | Antibodies to Phosphorylated IRAK4 |
| KR101812813B1 (ko) | 2009-06-16 | 2017-12-27 | 젠자임 코포레이션 | 재조합 ａａｖ 벡터에 대한 개선된 정제 방법 |
| US20110070241A1 (en) * | 2009-06-30 | 2011-03-24 | Duke University | Methods for modulating immune responses to aav gene therapy vectors |
| EP3567106A1 (en) | 2010-04-23 | 2019-11-13 | University of Massachusetts | Cns targeting aav vectors and methods of use thereof |
| CN106413715A (zh) | 2014-04-22 | 2017-02-15 | 林伯士艾瑞斯公司 | Irak抑制剂和其用途 |
| EP3200788B1 (en) | 2014-09-30 | 2019-09-18 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| US10040798B2 (en) | 2015-03-12 | 2018-08-07 | Merck Sharp & Dohme Corp. | Pyrrolopyridazine inhibitors of IRAK4 activity |
| WO2017004133A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN108024971A (zh) | 2015-07-15 | 2018-05-11 | 奥列基因发现技术有限公司 | 作为irak-4抑制剂的取代的氮杂化合物 |
| US10988482B2 (en) | 2015-08-13 | 2021-04-27 | Beijing Hanmi Pharmaceutical Co., Ltd. | IRAK4 inhibitor and use thereof |
| ES2946001T3 (es) | 2016-10-26 | 2023-07-11 | Rigel Pharmaceuticals Inc | Compuestos de pirazol amida como inhibidores de IRAK |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| CA3090275A1 (en) | 2018-02-14 | 2019-08-22 | Dana-Farber Cancer Institute, Inc. | Irak degraders and uses thereof |
| MX2020009234A (es) | 2018-04-05 | 2020-10-12 | Merck Patent Gmbh | Compuestos de heteroarilo como inhibidores de cinasas asociadas con receptores de interleucina-1 (irak) tipo ii y usos de los mismos. |
| AU2019294836B2 (en) | 2018-06-29 | 2024-06-20 | Dana-Farber Cancer Institute, Inc. | Bispecific degraders |
| JP7623943B2 (ja) | 2018-11-30 | 2025-01-29 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| WO2020264490A1 (en) | 2019-06-28 | 2020-12-30 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| US12528814B2 (en) | 2020-02-19 | 2026-01-20 | Nurix Therapeutics, Inc. | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
| WO2021231575A1 (en) * | 2020-05-12 | 2021-11-18 | Myogene Bio Llc | Immunosuppressive agents and viral delivery re-dosing methods for gene therapy |
| WO2021247897A1 (en) | 2020-06-03 | 2021-12-09 | Kymera Therapeutics, Inc. | Deuterated irak degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
-
2023
- 2023-04-12 AU AU2023252915A patent/AU2023252915A1/en active Pending
- 2023-04-12 CN CN202380043587.1A patent/CN119630802A/zh active Pending
- 2023-04-12 TW TW112113694A patent/TW202400250A/zh unknown
- 2023-04-12 JP JP2024560404A patent/JP2025513850A/ja active Pending
- 2023-04-12 EP EP23722239.3A patent/EP4508225A1/en active Pending
- 2023-04-12 CA CA3248481A patent/CA3248481A1/en active Pending
- 2023-04-12 IL IL316231A patent/IL316231A/en unknown
- 2023-04-12 WO PCT/US2023/065687 patent/WO2023201272A1/en not_active Ceased
- 2023-04-12 US US18/299,632 patent/US20230405151A1/en active Pending
- 2023-04-12 KR KR1020247037276A patent/KR20250004740A/ko active Pending
-
2024
- 2024-10-10 MX MX2024012616A patent/MX2024012616A/es unknown
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