JP2025511404A - オシメルチニブを製造するための改善されたプロセス - Google Patents
オシメルチニブを製造するための改善されたプロセス Download PDFInfo
- Publication number
- JP2025511404A JP2025511404A JP2024559037A JP2024559037A JP2025511404A JP 2025511404 A JP2025511404 A JP 2025511404A JP 2024559037 A JP2024559037 A JP 2024559037A JP 2024559037 A JP2024559037 A JP 2024559037A JP 2025511404 A JP2025511404 A JP 2025511404A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- reaction
- carried out
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epidemiology (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263362622P | 2022-04-07 | 2022-04-07 | |
| US63/362,622 | 2022-04-07 | ||
| PCT/EP2023/059132 WO2023194531A1 (en) | 2022-04-07 | 2023-04-06 | Improved process for the manufacture of osimertinib |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025511404A true JP2025511404A (ja) | 2025-04-15 |
| JP2025511404A5 JP2025511404A5 (https=) | 2026-04-14 |
Family
ID=86142780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024559037A Pending JP2025511404A (ja) | 2022-04-07 | 2023-04-06 | オシメルチニブを製造するための改善されたプロセス |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20250250255A1 (https=) |
| EP (1) | EP4504718A1 (https=) |
| JP (1) | JP2025511404A (https=) |
| KR (1) | KR20250002363A (https=) |
| CN (1) | CN119317624A (https=) |
| AR (1) | AR128999A1 (https=) |
| AU (1) | AU2023250220A1 (https=) |
| CA (1) | CA3255378A1 (https=) |
| CO (1) | CO2024015096A2 (https=) |
| IL (1) | IL316018A (https=) |
| MX (1) | MX2024012370A (https=) |
| TW (1) | TW202404955A (https=) |
| WO (1) | WO2023194531A1 (https=) |
| ZA (1) | ZA202408113B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120717920A (zh) * | 2025-08-18 | 2025-09-30 | 爱斯特（成都）生物制药股份有限公司 | 一种微通道连续合成3-硝基-4-氟苯腈的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4119551A1 (en) | 2011-07-27 | 2023-01-18 | Astrazeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine compounds |
| CN106883216B (zh) * | 2017-04-06 | 2020-03-13 | 张家港威胜生物医药有限公司 | 一种奥希替尼的制备方法 |
| IN201741031902A (https=) * | 2017-09-08 | 2019-03-15 | Msn Laboratories Private Ltd | |
| CN109134435B (zh) | 2018-10-29 | 2023-01-03 | 湖南大学 | 一种奥希替尼azd9291的合成方法 |
-
2023
- 2023-04-05 AR ARP230100846A patent/AR128999A1/es unknown
- 2023-04-06 WO PCT/EP2023/059132 patent/WO2023194531A1/en not_active Ceased
- 2023-04-06 KR KR1020247036946A patent/KR20250002363A/ko active Pending
- 2023-04-06 CN CN202380044986.XA patent/CN119317624A/zh active Pending
- 2023-04-06 EP EP23718993.1A patent/EP4504718A1/en active Pending
- 2023-04-06 IL IL316018A patent/IL316018A/en unknown
- 2023-04-06 AU AU2023250220A patent/AU2023250220A1/en active Pending
- 2023-04-06 JP JP2024559037A patent/JP2025511404A/ja active Pending
- 2023-04-06 CA CA3255378A patent/CA3255378A1/en active Pending
- 2023-04-06 US US18/854,716 patent/US20250250255A1/en active Pending
- 2023-04-07 TW TW112112997A patent/TW202404955A/zh unknown
-
2024
- 2024-10-04 MX MX2024012370A patent/MX2024012370A/es unknown
- 2024-10-28 ZA ZA2024/08113A patent/ZA202408113B/en unknown
- 2024-11-05 CO CONC2024/0015096A patent/CO2024015096A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN119317624A (zh) | 2025-01-14 |
| AR128999A1 (es) | 2024-07-03 |
| ZA202408113B (en) | 2025-07-30 |
| KR20250002363A (ko) | 2025-01-07 |
| TW202404955A (zh) | 2024-02-01 |
| WO2023194531A1 (en) | 2023-10-12 |
| MX2024012370A (es) | 2024-11-08 |
| AU2023250220A1 (en) | 2024-11-07 |
| IL316018A (en) | 2024-11-01 |
| CO2024015096A2 (es) | 2024-11-28 |
| EP4504718A1 (en) | 2025-02-12 |
| CA3255378A1 (en) | 2023-10-12 |
| US20250250255A1 (en) | 2025-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20260406 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20260406 |