JP2025506098A - 結晶質プロスタサイクリン（ｉｐ）受容体アゴニストおよびその使用 - Google Patents

結晶質プロスタサイクリン（ｉｐ）受容体アゴニストおよびその使用 Download PDF

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JP2025506098A
JP2025506098A JP2024543285A JP2024543285A JP2025506098A JP 2025506098 A JP2025506098 A JP 2025506098A JP 2024543285 A JP2024543285 A JP 2024543285A JP 2024543285 A JP2024543285 A JP 2024543285A JP 2025506098 A JP2025506098 A JP 2025506098A
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pattern
xrpd
crystalline form
lalinepag
ralinepag
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JP2025506098A5 (enExample
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ファレス，ケネス
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ユナイテッド セラピューティクス コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024543285A 2022-02-15 2023-02-14 結晶質プロスタサイクリン（ｉｐ）受容体アゴニストおよびその使用 Pending JP2025506098A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263310469P 2022-02-15 2022-02-15
US63/310,469 2022-02-15
PCT/US2023/013032 WO2023158634A1 (en) 2022-02-15 2023-02-14 Crystalline prostacyclin (ip) receptor agonist and uses thereof

Publications (2)

Publication Number Publication Date
JP2025506098A true JP2025506098A (ja) 2025-03-07
JP2025506098A5 JP2025506098A5 (enExample) 2026-02-20

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JP2024543285A Pending JP2025506098A (ja) 2022-02-15 2023-02-14 結晶質プロスタサイクリン（ｉｐ）受容体アゴニストおよびその使用

Country Status (9)

Country Link
US (2) US12098116B2 (enExample)
EP (1) EP4479374A1 (enExample)
JP (1) JP2025506098A (enExample)
KR (1) KR20240149924A (enExample)
CN (1) CN118922402A (enExample)
AU (1) AU2023222747A1 (enExample)
CA (1) CA3248736A1 (enExample)
IL (1) IL314717A (enExample)
WO (1) WO2023158634A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023158634A1 (en) 2022-02-15 2023-08-24 United Therapeutics Corporation Crystalline prostacyclin (ip) receptor agonist and uses thereof
IL320516A (en) 2022-10-31 2025-06-01 United Therapeutics Corp Methods for treating pulmonary hypertension
US20250282716A1 (en) 2024-03-11 2025-09-11 United Therapeutics Corporation Methods of making ip-receptor agonists

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Publication number Publication date
AU2023222747A1 (en) 2024-08-22
US20230406815A1 (en) 2023-12-21
WO2023158634A1 (en) 2023-08-24
US20240409503A1 (en) 2024-12-12
KR20240149924A (ko) 2024-10-15
EP4479374A1 (en) 2024-12-25
US12098116B2 (en) 2024-09-24
IL314717A (en) 2024-10-01
CN118922402A (zh) 2024-11-08
CA3248736A1 (en) 2023-08-24

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