JP2025505521A - 大環状ペプチドを製造するための方法 - Google Patents

大環状ペプチドを製造するための方法 Download PDF

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Publication number
JP2025505521A
JP2025505521A JP2024543160A JP2024543160A JP2025505521A JP 2025505521 A JP2025505521 A JP 2025505521A JP 2024543160 A JP2024543160 A JP 2024543160A JP 2024543160 A JP2024543160 A JP 2024543160A JP 2025505521 A JP2025505521 A JP 2025505521A
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JP
Japan
Prior art keywords
compound
formula
fmoc
boc
reaction mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024543160A
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English (en)
Japanese (ja)
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JP2025505521A5 (https=
Inventor
アダム,ジャン-ミッシェル
ブリス,フリッツ
ドット,パスカル・ジャン・クロード
ホフマン-エメリー,ファビエンヌ・ロクサーヌ
ラーション,ウルフ・ゲラン
プエンテナー,クルト
ヴュイチック,ゲオルク
ヨスト,ヴェラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2025505521A publication Critical patent/JP2025505521A/ja
Publication of JP2025505521A5 publication Critical patent/JP2025505521A5/ja
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0815Tripeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2024543160A 2022-02-14 2023-02-13 大環状ペプチドを製造するための方法 Pending JP2025505521A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22156480.0 2022-02-14
EP22156480 2022-02-14
PCT/EP2023/053409 WO2023152347A1 (en) 2022-02-14 2023-02-13 Process for manufacturing macrocyclic peptides

Publications (2)

Publication Number Publication Date
JP2025505521A true JP2025505521A (ja) 2025-02-28
JP2025505521A5 JP2025505521A5 (https=) 2026-02-09

Family

ID=80683163

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024543160A Pending JP2025505521A (ja) 2022-02-14 2023-02-13 大環状ペプチドを製造するための方法

Country Status (12)

Country Link
US (1) US20250109166A1 (https=)
EP (1) EP4479396A1 (https=)
JP (1) JP2025505521A (https=)
KR (1) KR20240144894A (https=)
CN (1) CN118660878A (https=)
AR (1) AR128501A1 (https=)
AU (1) AU2023217269A1 (https=)
CA (1) CA3237617A1 (https=)
IL (1) IL313664A (https=)
MX (1) MX2024009210A (https=)
TW (1) TW202342493A (https=)
WO (1) WO2023152347A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026068674A1 (en) 2024-09-27 2026-04-02 F. Hoffmann-La Roche Ag Process for deprotection of aminoacid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6136934B2 (ja) 2011-12-15 2017-05-31 味の素株式会社 Fmoc基の除去方法
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii

Also Published As

Publication number Publication date
CN118660878A (zh) 2024-09-17
EP4479396A1 (en) 2024-12-25
TW202342493A (zh) 2023-11-01
CA3237617A1 (en) 2023-08-17
IL313664A (en) 2024-08-01
WO2023152347A1 (en) 2023-08-17
AR128501A1 (es) 2024-05-15
MX2024009210A (es) 2024-08-06
US20250109166A1 (en) 2025-04-03
KR20240144894A (ko) 2024-10-04
AU2023217269A1 (en) 2024-05-16

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