JP2025505521A - 大環状ペプチドを製造するための方法 - Google Patents
大環状ペプチドを製造するための方法 Download PDFInfo
- Publication number
- JP2025505521A JP2025505521A JP2024543160A JP2024543160A JP2025505521A JP 2025505521 A JP2025505521 A JP 2025505521A JP 2024543160 A JP2024543160 A JP 2024543160A JP 2024543160 A JP2024543160 A JP 2024543160A JP 2025505521 A JP2025505521 A JP 2025505521A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- fmoc
- boc
- reaction mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22156480.0 | 2022-02-14 | ||
| EP22156480 | 2022-02-14 | ||
| PCT/EP2023/053409 WO2023152347A1 (en) | 2022-02-14 | 2023-02-13 | Process for manufacturing macrocyclic peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025505521A true JP2025505521A (ja) | 2025-02-28 |
| JP2025505521A5 JP2025505521A5 (https=) | 2026-02-09 |
Family
ID=80683163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024543160A Pending JP2025505521A (ja) | 2022-02-14 | 2023-02-13 | 大環状ペプチドを製造するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20250109166A1 (https=) |
| EP (1) | EP4479396A1 (https=) |
| JP (1) | JP2025505521A (https=) |
| KR (1) | KR20240144894A (https=) |
| CN (1) | CN118660878A (https=) |
| AR (1) | AR128501A1 (https=) |
| AU (1) | AU2023217269A1 (https=) |
| CA (1) | CA3237617A1 (https=) |
| IL (1) | IL313664A (https=) |
| MX (1) | MX2024009210A (https=) |
| TW (1) | TW202342493A (https=) |
| WO (1) | WO2023152347A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2026068674A1 (en) | 2024-09-27 | 2026-04-02 | F. Hoffmann-La Roche Ag | Process for deprotection of aminoacid derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6136934B2 (ja) | 2011-12-15 | 2017-05-31 | 味の素株式会社 | Fmoc基の除去方法 |
| US11819532B2 (en) | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
-
2023
- 2023-02-13 WO PCT/EP2023/053409 patent/WO2023152347A1/en not_active Ceased
- 2023-02-13 MX MX2024009210A patent/MX2024009210A/es unknown
- 2023-02-13 AR ARP230100321A patent/AR128501A1/es unknown
- 2023-02-13 CN CN202380019392.3A patent/CN118660878A/zh active Pending
- 2023-02-13 EP EP23703601.7A patent/EP4479396A1/en active Pending
- 2023-02-13 IL IL313664A patent/IL313664A/en unknown
- 2023-02-13 TW TW112104963A patent/TW202342493A/zh unknown
- 2023-02-13 CA CA3237617A patent/CA3237617A1/en active Pending
- 2023-02-13 KR KR1020247023022A patent/KR20240144894A/ko active Pending
- 2023-02-13 JP JP2024543160A patent/JP2025505521A/ja active Pending
- 2023-02-13 AU AU2023217269A patent/AU2023217269A1/en active Pending
-
2024
- 2024-08-13 US US18/803,333 patent/US20250109166A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN118660878A (zh) | 2024-09-17 |
| EP4479396A1 (en) | 2024-12-25 |
| TW202342493A (zh) | 2023-11-01 |
| CA3237617A1 (en) | 2023-08-17 |
| IL313664A (en) | 2024-08-01 |
| WO2023152347A1 (en) | 2023-08-17 |
| AR128501A1 (es) | 2024-05-15 |
| MX2024009210A (es) | 2024-08-06 |
| US20250109166A1 (en) | 2025-04-03 |
| KR20240144894A (ko) | 2024-10-04 |
| AU2023217269A1 (en) | 2024-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101467598B1 (ko) | Hcv 프로테아제 억제제 중간체의 제조방법 | |
| JP5789260B2 (ja) | C型肝炎ウイルスのプロテアーゼ阻害薬の調製方法 | |
| TWI887230B (zh) | 肽化合物的製造方法、保護基形成用試藥及縮合多環芳香族烴化合物 | |
| CN115315438A (zh) | 索玛鲁肽侧链的改进制备方法 | |
| CN107810189B (zh) | 用于制备氮芥衍生物的方法 | |
| JP2025505521A (ja) | 大環状ペプチドを製造するための方法 | |
| RU2499792C2 (ru) | Усовершенствованный способ получения ингибитора дипептидилпептидазы-iv и промежуточного соединения | |
| JP2016515139A (ja) | ソバプレビルの新規の製造方法 | |
| JP2002502378A (ja) | グアニジル化試薬 | |
| CN114667136A (zh) | Trofinetide的组合物 | |
| CN110423265A (zh) | 一种环肽类trf2抑制剂的制备方法和用途 | |
| US20240262805A1 (en) | Method for producing compound or pharmaceutically acceptable salt thereof | |
| HK40111281A (zh) | 用於制造大环肽的方法 | |
| WO2020053795A2 (en) | Process for the preparation of acalabrutinib and its intermediates | |
| TW202302620A (zh) | 胺基酸或肽之製造方法、保護基形成用試藥及化合物 | |
| JP2007501250A (ja) | ペプチジル複素環式ケトン誘導体および製造方法 | |
| CZ2003165A3 (cs) | Způsob přípravy solí 5-fenylpentanoyl-(S)-alanyl-(S)-arginyl-(S)-alanyl-{(S)-2-[(R)-3-amino-2-oxopyrrolidin-1-yl]propionyl}-(S)-alanyl-(S)-arginyl-(S)-alanyl-4-aminofenylacetamidu | |
| ES2286325T3 (es) | Forma cristalina de clorhidrato de quinapril y proceso para su preparacion. | |
| JP2004502673A (ja) | ジスタマイシン誘導体の合成方法 | |
| HK40106397A (zh) | 化合物或其药学上允许的盐的制造方法 | |
| HK40060361B (zh) | 用於制备galnac亚磷酰胺差向异构体的方法 | |
| CN114787171A (zh) | ((2s)-3-([1,1’-联苯]-4-基)-2-((羟基((1r)-1-(((1-(异丁酰氧基)乙氧基)羰基)氨基)乙基)磷酰基)甲基)丙酰基)-l-丙氨酸的二钠盐的工业制备方法 | |
| WO2019200114A1 (en) | Methods for preparing substituted dihydroindene-4-carboxamide compounds | |
| HK1162179A (en) | Process for the preparation of 2-(primary/secondary amino)hydrocarbyl)- carbamoyl-7-oxo-2,6-diaza-bicyclo[3.2.0.]heptane-6-sulfonic acid derivatives | |
| WO2019066578A1 (ko) | 의약품 합성용 중간체 화합물의 제조 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250122 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20250122 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20260129 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20260129 |