AR128501A1 - Proceso para fabricar péptidos macrocíclicos - Google Patents

Proceso para fabricar péptidos macrocíclicos

Info

Publication number
AR128501A1
AR128501A1 ARP230100321A ARP230100321A AR128501A1 AR 128501 A1 AR128501 A1 AR 128501A1 AR P230100321 A ARP230100321 A AR P230100321A AR P230100321 A ARP230100321 A AR P230100321A AR 128501 A1 AR128501 A1 AR 128501A1
Authority
AR
Argentina
Prior art keywords
manufacture
macrocyclic peptides
manufacturing
salt
compound
Prior art date
Application number
ARP230100321A
Other languages
English (en)
Spanish (es)
Inventor
Jean Adam
- Bliss Fritz Michel
Pascal Jean Claude Dott
Fabienne Roxane Hoffmann-Emery
Ulf Goeran Larsson
Kurt Puentener
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR128501A1 publication Critical patent/AR128501A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0815Tripeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ARP230100321A 2022-02-14 2023-02-13 Proceso para fabricar péptidos macrocíclicos AR128501A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP22156480 2022-02-14

Publications (1)

Publication Number Publication Date
AR128501A1 true AR128501A1 (es) 2024-05-15

Family

ID=80683163

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230100321A AR128501A1 (es) 2022-02-14 2023-02-13 Proceso para fabricar péptidos macrocíclicos

Country Status (12)

Country Link
US (1) US20250109166A1 (https=)
EP (1) EP4479396A1 (https=)
JP (1) JP2025505521A (https=)
KR (1) KR20240144894A (https=)
CN (1) CN118660878A (https=)
AR (1) AR128501A1 (https=)
AU (1) AU2023217269A1 (https=)
CA (1) CA3237617A1 (https=)
IL (1) IL313664A (https=)
MX (1) MX2024009210A (https=)
TW (1) TW202342493A (https=)
WO (1) WO2023152347A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026068674A1 (en) 2024-09-27 2026-04-02 F. Hoffmann-La Roche Ag Process for deprotection of aminoacid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6136934B2 (ja) 2011-12-15 2017-05-31 味の素株式会社 Fmoc基の除去方法
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii

Also Published As

Publication number Publication date
CN118660878A (zh) 2024-09-17
EP4479396A1 (en) 2024-12-25
TW202342493A (zh) 2023-11-01
CA3237617A1 (en) 2023-08-17
IL313664A (en) 2024-08-01
WO2023152347A1 (en) 2023-08-17
JP2025505521A (ja) 2025-02-28
MX2024009210A (es) 2024-08-06
US20250109166A1 (en) 2025-04-03
KR20240144894A (ko) 2024-10-04
AU2023217269A1 (en) 2024-05-16

Similar Documents

Publication Publication Date Title
AR125304A1 (es) Compuestos de oxazepina acíclicos y usos de los mismos
CL2025002160A1 (es) Compuestos tricíclicos para el tratamiento de cáncer
BR112023022755A2 (pt) Composto cíclico possuindo efeito inibidor seletivo para kras, mas não para hras e nras
AR128501A1 (es) Proceso para fabricar péptidos macrocíclicos
AR123268A1 (es) Proceso e intermediarios para preparar un inhibidor de jak1
RU2011115077A (ru) Пептидные антибиотики и способы их получения
PE20181045A1 (es) Compuestos utiles como inmunomoduladores
GB853044A (en) Novel phosphoric and thiophosphoric acid ester amides and the production thereof
JOP20230033A1 (ar) عملية ومركبات وسيطة لتحضير مثبط Jak
ATE336991T1 (de) Bis(thio-hydrazid amid) verbindungen zur behandlung von mehrfach resistenten krebs
AR133266A1 (es) Macrociclos para el tratamiento de enfermedades autoinmunitarias
ES2059294T1 (es) Inhibidores de proteasas retroviricas.
CL2021003568A1 (es) Compuestos heteroaromáticos como inhibidores de vanina (divisional de solicitud n° 202101198)
DOP2025000069A (es) Inhibidores de sik novedosos
CO2021000207A2 (es) Compuestos de isoxazolina para controlar plagas de invertebrados
MX2025001261A (es) Proceso para fabricar un peptido macrociclico antibiotico
CO2025004541A2 (es) Insecticidas de pirazolamida
ES8104187A1 (es) Procedimiento para la preparacion de derivados de 1-fe- nil-2-aminoetanol
AR134089A1 (es) Nuevos compuestos
AR130194A1 (es) Derivados de tetrahidrotiazepina bicíclicos
CO2025012295A2 (es) Síntesis de soporte peptídico en fase líquida de péptidos y peptidomiméticos
MX2023006103A (es) Composicion de nematodos depredadores y metodos de uso de los mismos.
MX2025013208A (es) Inhibidor de btk para el tratamiento de la esclerosis múltiple
MX2022013205A (es) Proceso para la preparacion de un acido piperazin-2-carboxilico quiral.
AR130167A1 (es) Derivados bicíclicos de tetrahidroazepina