JP2025504419A - 抗ＣＤ７９ｂ抗体薬物複合体を含む医薬組成物及びその使用 - Google Patents

抗ＣＤ７９ｂ抗体薬物複合体を含む医薬組成物及びその使用 Download PDF

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JP2025504419A
JP2025504419A JP2024541905A JP2024541905A JP2025504419A JP 2025504419 A JP2025504419 A JP 2025504419A JP 2024541905 A JP2024541905 A JP 2024541905A JP 2024541905 A JP2024541905 A JP 2024541905A JP 2025504419 A JP2025504419 A JP 2025504419A
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group
pharmaceutical composition
ligand
histidine
buffer
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JP2025504419A5 (https=
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立君 沈
志竜 趙
辰翔 湯
磊 李
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上▲海▼▲邁▼晋生物医▲薬▼科技有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6873—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an immunoglobulin; the antibody being an anti-idiotypic antibody
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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  • Bioinformatics & Cheminformatics (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Cell Biology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2024541905A 2022-01-26 2023-01-19 抗ＣＤ７９ｂ抗体薬物複合体を含む医薬組成物及びその使用 Pending JP2025504419A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202210093514 2022-01-26
CN202210093514.0 2022-01-26
PCT/CN2023/073047 WO2023143347A1 (zh) 2022-01-26 2023-01-19 一种包含抗CD79b抗体药物偶联物的药物组合物及其用途

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Publication Number Publication Date
JP2025504419A true JP2025504419A (ja) 2025-02-12
JP2025504419A5 JP2025504419A5 (https=) 2026-01-27

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US (1) US20250108122A1 (https=)
EP (1) EP4470568A4 (https=)
JP (1) JP2025504419A (https=)
KR (1) KR20240135622A (https=)
CN (1) CN118382463A (https=)
AU (1) AU2023212240A1 (https=)
CA (1) CA3248952A1 (https=)
MX (1) MX2024009079A (https=)
TW (1) TW202334207A (https=)
WO (1) WO2023143347A1 (https=)

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WO2025162364A1 (zh) * 2024-02-02 2025-08-07 江苏恒瑞医药股份有限公司 抗CD79b抗体药物偶联物联合免疫治疗剂、化疗剂治疗肿瘤
CN121401438A (zh) * 2024-07-26 2026-01-27 英诺湖医药(杭州)有限公司 一种抗b7h3抗体-艾瑞布林偶联物制剂及其制备方法和应用

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AU2018320470B2 (en) * 2017-08-23 2025-04-24 Daiichi Sankyo Company, Limited Antibody-drug conjugate preparation and lyophilization for same
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WO2020063676A1 (zh) 2018-09-26 2020-04-02 江苏恒瑞医药股份有限公司 依喜替康类似物的配体-药物偶联物及其制备方法和应用
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CN113286823B (zh) 2019-01-28 2024-05-07 上海拓界生物医药科技有限公司 抗cd79b抗体、其抗原结合片段及其医药用途
CN111939267B (zh) * 2019-05-17 2024-12-20 百奥泰生物制药股份有限公司 抗体-药物偶联物制剂、制备方法及应用
CN113116812A (zh) * 2019-12-30 2021-07-16 百奥泰生物制药股份有限公司 含抗Trop2抗体-药物偶联物的制剂及其制备方法和应用
JP7821733B2 (ja) * 2020-01-22 2026-02-27 上海森輝医薬有限公司 エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用
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KR20240135622A (ko) 2024-09-11
CN118382463A (zh) 2024-07-23
EP4470568A1 (en) 2024-12-04
WO2023143347A1 (zh) 2023-08-03
AU2023212240A1 (en) 2024-07-11
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