JP2025011201A5 - - Google Patents
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- Publication number
- JP2025011201A5 JP2025011201A5 JP2024177043A JP2024177043A JP2025011201A5 JP 2025011201 A5 JP2025011201 A5 JP 2025011201A5 JP 2024177043 A JP2024177043 A JP 2024177043A JP 2024177043 A JP2024177043 A JP 2024177043A JP 2025011201 A5 JP2025011201 A5 JP 2025011201A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- substitution
- killer cell
- antigen
- hiv antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006467 substitution reaction Methods 0.000 claims 42
- 230000036436 anti-hiv Effects 0.000 claims 23
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 102000005962 receptors Human genes 0.000 claims 10
- 108020003175 receptors Proteins 0.000 claims 10
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims 9
- 102100029197 SLAM family member 6 Human genes 0.000 claims 9
- 102100029198 SLAM family member 7 Human genes 0.000 claims 9
- 102100027744 Semaphorin-4D Human genes 0.000 claims 9
- 102100033447 T-lymphocyte surface antigen Ly-9 Human genes 0.000 claims 9
- 230000003013 cytotoxicity Effects 0.000 claims 9
- 231100000135 cytotoxicity Toxicity 0.000 claims 9
- 230000001939 inductive effect Effects 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 8
- 108010043610 KIR Receptors Proteins 0.000 claims 8
- 102000002698 KIR Receptors Human genes 0.000 claims 8
- 210000005220 cytoplasmic tail Anatomy 0.000 claims 8
- 108010056102 CD100 antigen Proteins 0.000 claims 6
- 102100038077 CD226 antigen Human genes 0.000 claims 6
- 102100027207 CD27 antigen Human genes 0.000 claims 6
- 102100036008 CD48 antigen Human genes 0.000 claims 6
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims 6
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 6
- 101000945351 Homo sapiens Killer cell immunoglobulin-like receptor 3DL1 Proteins 0.000 claims 6
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 6
- 101001109472 Homo sapiens NKG2-F type II integral membrane protein Proteins 0.000 claims 6
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims 6
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 claims 6
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims 6
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 6
- 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 claims 6
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 6
- 102100022701 NKG2-E type II integral membrane protein Human genes 0.000 claims 6
- 101710123354 NKG2-E type II integral membrane protein Proteins 0.000 claims 6
- 102100022700 NKG2-F type II integral membrane protein Human genes 0.000 claims 6
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 6
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims 6
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 6
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 claims 6
- 101710114141 T-lymphocyte surface antigen Ly-9 Proteins 0.000 claims 6
- 101001027081 Homo sapiens Killer cell immunoglobulin-like receptor 2DL1 Proteins 0.000 claims 5
- 101000945333 Homo sapiens Killer cell immunoglobulin-like receptor 2DL3 Proteins 0.000 claims 5
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 5
- 102100037363 Killer cell immunoglobulin-like receptor 2DL1 Human genes 0.000 claims 5
- 102100033634 Killer cell immunoglobulin-like receptor 2DL3 Human genes 0.000 claims 5
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 5
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims 5
- 210000004748 cultured cell Anatomy 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 3
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 3
- 108010038940 CD48 Antigen Proteins 0.000 claims 3
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 3
- 101710167716 Cytotoxic and regulatory T-cell molecule Proteins 0.000 claims 3
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims 3
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 3
- 101000589301 Homo sapiens Natural cytotoxicity triggering receptor 1 Proteins 0.000 claims 3
- 101000589307 Homo sapiens Natural cytotoxicity triggering receptor 3 Proteins 0.000 claims 3
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims 3
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 3
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 3
- 108010073807 IgG Receptors Proteins 0.000 claims 3
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 3
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 3
- 108010039435 NK Cell Lectin-Like Receptors Proteins 0.000 claims 3
- 102000015223 NK Cell Lectin-Like Receptors Human genes 0.000 claims 3
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 3
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims 3
- 102220631459 Putative uncharacterized protein H1-10-AS1_G54W_mutation Human genes 0.000 claims 3
- 102100029216 SLAM family member 5 Human genes 0.000 claims 3
- 101710083278 SLAM family member 6 Proteins 0.000 claims 3
- 101710083287 SLAM family member 7 Proteins 0.000 claims 3
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 3
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 239000003443 antiviral agent Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102220493349 40S ribosomal protein S3_T70R_mutation Human genes 0.000 claims 2
- 102220536893 Aryl hydrocarbon receptor nuclear translocator-like protein 1_N70D_mutation Human genes 0.000 claims 2
- 101100160804 Bacillus subtilis (strain 168) yxaD gene Proteins 0.000 claims 2
- 102220534918 Importin subunit alpha-6_S61D_mutation Human genes 0.000 claims 2
- 102220534913 Importin subunit alpha-6_S63D_mutation Human genes 0.000 claims 2
- 102220498159 Lipoma-preferred partner_S22D_mutation Human genes 0.000 claims 2
- 102220528082 M1-specific T cell receptor alpha chain_S74D_mutation Human genes 0.000 claims 2
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims 2
- 102220609777 Nuclear protein MDM1_I20D_mutation Human genes 0.000 claims 2
- 102220474067 Protection of telomeres protein 1_S72D_mutation Human genes 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 102220523009 3'(2'),5'-bisphosphate nucleotidase 1_R59E_mutation Human genes 0.000 claims 1
- 102220496625 Aryl hydrocarbon receptor nuclear translocator-like protein 1_S78E_mutation Human genes 0.000 claims 1
- 102220615703 Beta-casein_R59D_mutation Human genes 0.000 claims 1
- 102220479099 CD59 glycoprotein_W65E_mutation Human genes 0.000 claims 1
- 102220548175 Cell division cycle-associated 7-like protein_S21D_mutation Human genes 0.000 claims 1
- 102220553751 Cyclic GMP-AMP synthase_T18E_mutation Human genes 0.000 claims 1
- 102220553774 Cyclic GMP-AMP synthase_T68E_mutation Human genes 0.000 claims 1
- 102220613149 Cyclin-Y-like protein 2_V57E_mutation Human genes 0.000 claims 1
- 102220521139 Dynein light chain Tctex-type 1_S82E_mutation Human genes 0.000 claims 1
- 102220614306 F-box only protein 4_S12E_mutation Human genes 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 102220545757 HLA class II histocompatibility antigen, DQ alpha 1 chain_V73D_mutation Human genes 0.000 claims 1
- 102220545754 HLA class II histocompatibility antigen, DQ alpha 1 chain_V73E_mutation Human genes 0.000 claims 1
- 102220514940 HMG domain-containing protein 3_S22E_mutation Human genes 0.000 claims 1
- 102220491624 Heat shock protein beta-1_S78D_mutation Human genes 0.000 claims 1
- 102220491632 Heat shock protein beta-1_S82D_mutation Human genes 0.000 claims 1
- 102220517925 Humanin_S14P_mutation Human genes 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 102220502536 Platelet-activating factor acetylhydrolase IB subunit alpha2_G55E_mutation Human genes 0.000 claims 1
- 102220573186 Protein adenylyltransferase SelO, mitochondrial_F79Y_mutation Human genes 0.000 claims 1
- 102220607950 Protein inturned_S74E_mutation Human genes 0.000 claims 1
- 102220547496 Ragulator complex protein LAMTOR1_V57D_mutation Human genes 0.000 claims 1
- 102220551726 Ras-related protein Rab-7L1_S72E_mutation Human genes 0.000 claims 1
- 102220518615 Repressor of RNA polymerase III transcription MAF1 homolog_S75D_mutation Human genes 0.000 claims 1
- 102220623373 Rhodopsin kinase GRK1_S21E_mutation Human genes 0.000 claims 1
- 102220608481 Suppressor of cytokine signaling 2_S61E_mutation Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000002850 integrase inhibitor Substances 0.000 claims 1
- 229940124524 integrase inhibitor Drugs 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102200077165 rs118204021 Human genes 0.000 claims 1
- 102220138536 rs146905561 Human genes 0.000 claims 1
- 102220292454 rs1557058441 Human genes 0.000 claims 1
- 102200093891 rs1869780 Human genes 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962871393P | 2019-07-08 | 2019-07-08 | |
| US62/871,393 | 2019-07-08 | ||
| JP2022500950A JP7700093B2 (ja) | 2019-07-08 | 2020-07-08 | 多反応性が低下した抗ｈｉｖワクチン抗体 |
| PCT/US2020/041138 WO2021007285A1 (en) | 2019-07-08 | 2020-07-08 | Anti-hiv vaccine antibodies with reduced polyreactivity |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500950A Division JP7700093B2 (ja) | 2019-07-08 | 2020-07-08 | 多反応性が低下した抗ｈｉｖワクチン抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025011201A JP2025011201A (ja) | 2025-01-23 |
| JP2025011201A5 true JP2025011201A5 (enExample) | 2025-03-03 |
Family
ID=74114255
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500950A Active JP7700093B2 (ja) | 2019-07-08 | 2020-07-08 | 多反応性が低下した抗ｈｉｖワクチン抗体 |
| JP2024177043A Pending JP2025011201A (ja) | 2019-07-08 | 2024-10-09 | 多反応性が低下した抗ｈｉｖワクチン抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500950A Active JP7700093B2 (ja) | 2019-07-08 | 2020-07-08 | 多反応性が低下した抗ｈｉｖワクチン抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12459990B2 (enExample) |
| EP (1) | EP3997119A4 (enExample) |
| JP (2) | JP7700093B2 (enExample) |
| KR (1) | KR20220047977A (enExample) |
| CN (1) | CN114641488A (enExample) |
| AU (1) | AU2020311902A1 (enExample) |
| CA (1) | CA3146372A1 (enExample) |
| TW (1) | TW202116800A (enExample) |
| WO (1) | WO2021007285A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024097957A1 (en) * | 2022-11-03 | 2024-05-10 | Duke University | Novel antibodies for hiv and methods of making and using the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013090644A2 (en) * | 2011-12-13 | 2013-06-20 | California Institute Of Technology | Anti-hiv antibodies having increased potency and breadth |
| WO2014205491A1 (en) | 2013-06-25 | 2014-12-31 | Monash University | Biological molecules and methods of use |
| US20180028658A1 (en) | 2015-02-16 | 2018-02-01 | New York Blood Center, Inc. | Antibody-drug conjugates for reducing the latent hiv reservoir |
| US10450368B2 (en) * | 2015-03-19 | 2019-10-22 | Duke University | HIV-1 neutralizing antibodies and uses thereof (CD4bs antibodies) |
| CA2983034A1 (en) * | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| EA201891186A1 (ru) * | 2015-12-15 | 2018-12-28 | Джилид Сайэнс, Инк. | Антитела, нейтрализующие вирус иммунодефицита человека |
| US11845787B2 (en) | 2017-03-27 | 2023-12-19 | The Wistar Institute Of Anatomy And Biology | DNA antibody constructs for use against HIV |
| PE20210685A1 (es) * | 2018-07-03 | 2021-04-08 | Gilead Sciences Inc | Anticuerpos que se dirigen al gp120 de vih y metodos de uso |
-
2020
- 2020-07-08 WO PCT/US2020/041138 patent/WO2021007285A1/en not_active Ceased
- 2020-07-08 JP JP2022500950A patent/JP7700093B2/ja active Active
- 2020-07-08 AU AU2020311902A patent/AU2020311902A1/en active Pending
- 2020-07-08 EP EP20836440.6A patent/EP3997119A4/en active Pending
- 2020-07-08 US US17/625,247 patent/US12459990B2/en active Active
- 2020-07-08 KR KR1020227004133A patent/KR20220047977A/ko active Pending
- 2020-07-08 CA CA3146372A patent/CA3146372A1/en active Pending
- 2020-07-08 TW TW109123108A patent/TW202116800A/zh unknown
- 2020-07-08 CN CN202080074694.7A patent/CN114641488A/zh active Pending
-
2024
- 2024-10-09 JP JP2024177043A patent/JP2025011201A/ja active Pending
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