JP2018526028A5 - - Google Patents

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Publication number
JP2018526028A5
JP2018526028A5 JP2018530657A JP2018530657A JP2018526028A5 JP 2018526028 A5 JP2018526028 A5 JP 2018526028A5 JP 2018530657 A JP2018530657 A JP 2018530657A JP 2018530657 A JP2018530657 A JP 2018530657A JP 2018526028 A5 JP2018526028 A5 JP 2018526028A5
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JP
Japan
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item
seq
car
isolated
vector
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JP2018530657A
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English (en)
Japanese (ja)
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JP2018526028A (ja
JP6980659B2 (ja
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Priority claimed from PCT/US2016/049493 external-priority patent/WO2017040529A1/en
Publication of JP2018526028A publication Critical patent/JP2018526028A/ja
Publication of JP2018526028A5 publication Critical patent/JP2018526028A5/ja
Priority to JP2021131289A priority Critical patent/JP2021180676A/ja
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Publication of JP6980659B2 publication Critical patent/JP6980659B2/ja
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JP2018530657A 2015-08-31 2016-08-30 抗シアリルtnキメラ抗原受容体 Active JP6980659B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021131289A JP2021180676A (ja) 2015-08-31 2021-08-11 抗シアリルtnキメラ抗原受容体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20150122727 2015-08-31
KR10-2015-0122727 2015-08-31
US201662317950P 2016-04-04 2016-04-04
US62/317,950 2016-04-04
PCT/US2016/049493 WO2017040529A1 (en) 2015-08-31 2016-08-30 Anti-sialyl tn chimeric antigen receptors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021131289A Division JP2021180676A (ja) 2015-08-31 2021-08-11 抗シアリルtnキメラ抗原受容体

Publications (3)

Publication Number Publication Date
JP2018526028A JP2018526028A (ja) 2018-09-13
JP2018526028A5 true JP2018526028A5 (enExample) 2019-10-10
JP6980659B2 JP6980659B2 (ja) 2021-12-15

Family

ID=58189051

Family Applications (2)

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JP2018530657A Active JP6980659B2 (ja) 2015-08-31 2016-08-30 抗シアリルtnキメラ抗原受容体
JP2021131289A Withdrawn JP2021180676A (ja) 2015-08-31 2021-08-11 抗シアリルtnキメラ抗原受容体

Family Applications After (1)

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JP2021131289A Withdrawn JP2021180676A (ja) 2015-08-31 2021-08-11 抗シアリルtnキメラ抗原受容体

Country Status (9)

Country Link
US (1) US11279769B2 (enExample)
EP (2) EP3344295B1 (enExample)
JP (2) JP6980659B2 (enExample)
KR (1) KR102715016B1 (enExample)
CN (1) CN108136014A (enExample)
AU (1) AU2016315704B2 (enExample)
CA (1) CA2996893A1 (enExample)
ES (1) ES2911015T3 (enExample)
WO (1) WO2017040529A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013352156B2 (en) 2012-11-27 2018-12-06 Children's Medical Center Corporation Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
SG10201809290SA (en) 2014-04-25 2019-01-30 Childrens Medical Ct Corp Compositions and Methods to Treating Hemoglobinopathies
JP7288302B2 (ja) 2015-05-08 2023-06-07 ザ チルドレンズ メディカル センター コーポレーション 胎児型ヘモグロビン再誘導のための、bcl11aエンハンサー機能性領域を標的とする方法
ES2911015T3 (es) 2015-08-31 2022-05-17 Helixmith Co Ltd Receptores quiméricos de antígeno anti-sialil Tn
EP3600448A4 (en) * 2017-03-29 2021-01-27 Bluebird Bio, Inc. VECTORS AND COMPOSITIONS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
US11261441B2 (en) 2017-03-29 2022-03-01 Bluebird Bio, Inc. Vectors and compositions for treating hemoglobinopathies
BR112019023540A2 (pt) 2017-05-10 2020-05-26 The Wistar Institute Of Anatomy And Biology Método para gerar uma sequência de ácidos nucleicos e para tratar um sujeito, anticorpo codificado por dna estruturalmente modificado, e, composição.
WO2018218135A1 (en) 2017-05-25 2018-11-29 The Children's Medical Center Corporation Bcl11a guide delivery
US20200306303A1 (en) * 2017-09-29 2020-10-01 Chiou Hwa YUH Methods and compositions enhancing survival and functionality of anti-tumor and anti-viral t cells
WO2019101998A1 (en) * 2017-11-24 2019-05-31 Onkimmune Limited Modified natural killer cells and natural killer cell lines targetting tumour cells
PT110526B (pt) * 2018-01-26 2021-02-04 Univ Nova De Lisboa Anticorpo, fragmento funcional ou sonda do mesmo contra antigénios tumorais
EP3787600A4 (en) 2018-05-02 2022-02-16 The Children's Medical Center Corporation ENHANCED BCL11A MICRORNAS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
KR20210040396A (ko) * 2018-08-01 2021-04-13 시티 오브 호프 Tag72-양성 종양의 치료를 위한, tag72 표적화된 키메라 항원 수용체 변형된 t 세포
MX2021001527A (es) 2018-08-08 2021-06-15 Dragonfly Therapeutics Inc Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor.
US20240216510A1 (en) * 2021-04-20 2024-07-04 Ramot At Tel-Aviv University Ltd. Chimeric antigen receptors to sialyl-tn glycan antigen
EP4326777A4 (en) * 2021-04-20 2024-09-04 Ramot at Tel-Aviv University Ltd. HUMANIZED ANTI-SIALYL-TN-GLYCAN ANTIBODIES AND USES THEREOF
WO2022246066A2 (en) * 2021-05-19 2022-11-24 Precision Biologics, Inc. Methods and compositions for treating hematological malignancies
US20250268940A1 (en) 2022-04-19 2025-08-28 Intellia Therapeutics, Inc. Chimeric antigen receptor compositions and uses

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
JP3540315B2 (ja) 1991-09-23 2004-07-07 メディカル リサーチ カウンシル キメラ抗体の製造−組合せアプローチ
EP0656946B2 (en) 1992-08-21 2010-03-31 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
DE69427974T2 (de) 1993-04-29 2001-12-06 Unilever N.V., Rotterdam Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
FR2777909B1 (fr) 1998-04-24 2002-08-02 Pasteur Institut Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex
DK1257632T3 (da) 2000-02-24 2008-01-28 Xcyte Therapies Inc Samtidig stimulering og opkoncentrering af celler
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6962810B2 (en) 2000-10-31 2005-11-08 University Of Notre Dame Du Lac Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac
AU2002257420A1 (en) 2001-05-01 2002-11-11 National Research Council Of Canada A system for inducible expression in eukaryotic cells
WO2003057171A2 (en) 2002-01-03 2003-07-17 The Trustees Of The University Of Pennsylvania Activation and expansion of t-cells using an engineered multivalent signaling platform
KR100620554B1 (ko) 2004-06-05 2006-09-06 한국생명공학연구원 Tag-72에 대한 인간화 항체
US20110047635A1 (en) 2006-08-28 2011-02-24 University of Hawail Methods and compositions for transposon-mediated transgenesis
JP2010505775A (ja) * 2006-10-04 2010-02-25 クーベンハヴンス・ユニヴェルシテット Muc1に対する癌特異的な免疫反応の産生及び癌特異的muc1抗体
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
SG11201400527XA (en) * 2011-09-16 2014-04-28 Univ Pennsylvania Rna engineered t cells for the treatment of cancer
PL2884999T3 (pl) * 2012-08-20 2021-07-05 Fred Hutchinson Cancer Research Center Sposób i kompozycje do immunoterapii komórkowej
US9405601B2 (en) 2012-12-20 2016-08-02 Mitsubishi Electric Corporation In-vehicle apparatus and program
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
WO2015054600A2 (en) * 2013-10-10 2015-04-16 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
EP3626748A1 (en) 2014-01-13 2020-03-25 Stephen J. Forman Chimeric antigen receptors (cars) having mutations in the fc spacer region and methods for their use
ES2911015T3 (es) 2015-08-31 2022-05-17 Helixmith Co Ltd Receptores quiméricos de antígeno anti-sialil Tn

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