CA3146372A1 - Anti-hiv vaccine antibodies with reduced polyreactivity - Google Patents
Anti-hiv vaccine antibodies with reduced polyreactivity Download PDFInfo
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- CA3146372A1 CA3146372A1 CA3146372A CA3146372A CA3146372A1 CA 3146372 A1 CA3146372 A1 CA 3146372A1 CA 3146372 A CA3146372 A CA 3146372A CA 3146372 A CA3146372 A CA 3146372A CA 3146372 A1 CA3146372 A1 CA 3146372A1
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- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201962871393P | 2019-07-08 | 2019-07-08 | |
| US62/871,393 | 2019-07-08 | ||
| PCT/US2020/041138 WO2021007285A1 (en) | 2019-07-08 | 2020-07-08 | Anti-hiv vaccine antibodies with reduced polyreactivity |
Publications (1)
| Publication Number | Publication Date |
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| CA3146372A1 true CA3146372A1 (en) | 2021-01-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3146372A Pending CA3146372A1 (en) | 2019-07-08 | 2020-07-08 | Anti-hiv vaccine antibodies with reduced polyreactivity |
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| EP (1) | EP3997119A4 (enExample) |
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| CN (1) | CN114641488A (enExample) |
| AU (1) | AU2020311902A1 (enExample) |
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| TW (1) | TW202116800A (enExample) |
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| WO2024097957A1 (en) * | 2022-11-03 | 2024-05-10 | Duke University | Novel antibodies for hiv and methods of making and using the same |
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| WO2013090644A2 (en) * | 2011-12-13 | 2013-06-20 | California Institute Of Technology | Anti-hiv antibodies having increased potency and breadth |
| WO2014205491A1 (en) | 2013-06-25 | 2014-12-31 | Monash University | Biological molecules and methods of use |
| US20180028658A1 (en) | 2015-02-16 | 2018-02-01 | New York Blood Center, Inc. | Antibody-drug conjugates for reducing the latent hiv reservoir |
| US10450368B2 (en) * | 2015-03-19 | 2019-10-22 | Duke University | HIV-1 neutralizing antibodies and uses thereof (CD4bs antibodies) |
| CA2983034A1 (en) * | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| EA201891186A1 (ru) * | 2015-12-15 | 2018-12-28 | Джилид Сайэнс, Инк. | Антитела, нейтрализующие вирус иммунодефицита человека |
| US11845787B2 (en) | 2017-03-27 | 2023-12-19 | The Wistar Institute Of Anatomy And Biology | DNA antibody constructs for use against HIV |
| PE20210685A1 (es) * | 2018-07-03 | 2021-04-08 | Gilead Sciences Inc | Anticuerpos que se dirigen al gp120 de vih y metodos de uso |
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2020
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- 2020-07-08 JP JP2022500950A patent/JP7700093B2/ja active Active
- 2020-07-08 AU AU2020311902A patent/AU2020311902A1/en active Pending
- 2020-07-08 EP EP20836440.6A patent/EP3997119A4/en active Pending
- 2020-07-08 US US17/625,247 patent/US12459990B2/en active Active
- 2020-07-08 KR KR1020227004133A patent/KR20220047977A/ko active Pending
- 2020-07-08 CA CA3146372A patent/CA3146372A1/en active Pending
- 2020-07-08 TW TW109123108A patent/TW202116800A/zh unknown
- 2020-07-08 CN CN202080074694.7A patent/CN114641488A/zh active Pending
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2024
- 2024-10-09 JP JP2024177043A patent/JP2025011201A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220047977A (ko) | 2022-04-19 |
| WO2021007285A1 (en) | 2021-01-14 |
| JP7700093B2 (ja) | 2025-06-30 |
| EP3997119A4 (en) | 2023-11-22 |
| US20220289829A1 (en) | 2022-09-15 |
| US12459990B2 (en) | 2025-11-04 |
| JP2025011201A (ja) | 2025-01-23 |
| EP3997119A1 (en) | 2022-05-18 |
| TW202116800A (zh) | 2021-05-01 |
| JP2022539877A (ja) | 2022-09-13 |
| CN114641488A (zh) | 2022-06-17 |
| AU2020311902A1 (en) | 2022-01-27 |
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