JP2025000867A5 - - Google Patents

Download PDF

Info

Publication number
JP2025000867A5
JP2025000867A5 JP2024171990A JP2024171990A JP2025000867A5 JP 2025000867 A5 JP2025000867 A5 JP 2025000867A5 JP 2024171990 A JP2024171990 A JP 2024171990A JP 2024171990 A JP2024171990 A JP 2024171990A JP 2025000867 A5 JP2025000867 A5 JP 2025000867A5
Authority
JP
Japan
Prior art keywords
aqueous formulation
histidine
polysorbate
sucrose
nacl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024171990A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025000867A (ja
Filing date
Publication date
Priority claimed from JP2021572507A external-priority patent/JP7565951B2/ja
Application filed filed Critical
Publication of JP2025000867A publication Critical patent/JP2025000867A/ja
Publication of JP2025000867A5 publication Critical patent/JP2025000867A5/ja
Pending legal-status Critical Current

Links

JP2024171990A 2019-06-07 2024-10-01 皮下投与に好適なFcRnインヒビターの医薬製剤 Pending JP2025000867A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962858806P 2019-06-07 2019-06-07
US62/858,806 2019-06-07
JP2021572507A JP7565951B2 (ja) 2019-06-07 2020-06-05 皮下投与に好適なFcRnインヒビターの医薬製剤
PCT/EP2020/065716 WO2020245420A1 (en) 2019-06-07 2020-06-05 PHARMACEUTICAL FORMULATIONS OF FcRn INHIBITORS SUITABLE FOR SUBCUTANEOUS ADMINISTRATION

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021572507A Division JP7565951B2 (ja) 2019-06-07 2020-06-05 皮下投与に好適なFcRnインヒビターの医薬製剤

Publications (2)

Publication Number Publication Date
JP2025000867A JP2025000867A (ja) 2025-01-07
JP2025000867A5 true JP2025000867A5 (https=) 2025-04-02

Family

ID=71069842

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021572507A Active JP7565951B2 (ja) 2019-06-07 2020-06-05 皮下投与に好適なFcRnインヒビターの医薬製剤
JP2024171990A Pending JP2025000867A (ja) 2019-06-07 2024-10-01 皮下投与に好適なFcRnインヒビターの医薬製剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021572507A Active JP7565951B2 (ja) 2019-06-07 2020-06-05 皮下投与に好適なFcRnインヒビターの医薬製剤

Country Status (16)

Country Link
US (3) US11591388B2 (https=)
EP (1) EP3980063A1 (https=)
JP (2) JP7565951B2 (https=)
KR (1) KR20220019018A (https=)
CN (1) CN114126647A (https=)
AU (1) AU2020286968A1 (https=)
BR (1) BR112021024632A2 (https=)
CA (1) CA3138072A1 (https=)
IL (1) IL288550A (https=)
MA (1) MA56102A (https=)
MX (1) MX2021014756A (https=)
MY (1) MY206582A (https=)
PH (1) PH12021552847A1 (https=)
SG (1) SG11202112010RA (https=)
WO (1) WO2020245420A1 (https=)
ZA (1) ZA202409851B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201605203UA (en) * 2013-12-24 2016-07-28 Argen X N V Fcrn antagonists and methods of use
CA3081144A1 (en) 2017-12-08 2019-06-13 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
US12202900B2 (en) 2018-06-08 2025-01-21 argenx BV Compositions and methods for treating immune thrombocytopenia
JP2023509195A (ja) 2020-01-08 2023-03-07 アルジェニクス ビーブイ 天疱瘡症を治療する方法
CN119698429A (zh) 2022-06-15 2025-03-25 阿根思有限公司 Fcrn结合分子及使用方法
TW202421195A (zh) * 2022-11-07 2024-06-01 比利時商阿根思公司 使用fcrn拮抗劑治療狼瘡性腎炎之方法
CN120659623A (zh) * 2023-01-12 2025-09-16 阿根思有限公司 用于使用fcrn拮抗剂治疗原发性干燥综合征的方法
WO2025233685A1 (en) * 2024-05-10 2025-11-13 argenx BV Intravenous fcrn antagonist formulations and methods of use thereof
WO2025233684A1 (en) * 2024-05-10 2025-11-13 argenx BV Subcutaneous formulations, pre-filled syringes and methods of use thereof

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62153300A (ja) 1985-12-26 1987-07-08 Teijin Ltd ヒト免疫グロブリンGFc領域蛋白質およびその製造方法
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5326856A (en) 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
CA2118508A1 (en) 1992-04-24 1993-11-11 Elizabeth S. Ward Recombinant production of immunoglobulin-like domains in prokaryotic cells
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
EP1658772A3 (en) 1995-01-17 2007-01-17 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
US6128119A (en) 1997-01-10 2000-10-03 Asahi Kogaku Kogyo Kabushiki Kaisha Beam shaping optical system
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
PL209392B1 (pl) 1999-01-15 2011-08-31 Genentech Inc Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
HUP0204475A2 (en) 2000-02-11 2003-04-28 Merck Patent Gmbh Enhancing the circulating half-life of antibody-based fusion proteins
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
WO2002043658A2 (en) 2000-11-06 2002-06-06 The Jackson Laboratory Fcrn-based therapeutics for the treatment of auto-immune disorders
WO2002040047A2 (en) 2000-11-20 2002-05-23 Canadian Blood Services Method for treating thrombocytopenia with monoclonal ivig
US7083784B2 (en) 2000-12-12 2006-08-01 Medimmune, Inc. Molecules with extended half-lives, compositions and uses thereof
NZ571596A (en) 2001-08-03 2010-11-26 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
JP3945281B2 (ja) 2002-03-19 2007-07-18 富士ゼロックス株式会社 画像形成装置
ATE483472T1 (de) 2002-05-30 2010-10-15 Macrogenics Inc Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
DK1534335T4 (en) 2002-08-14 2015-10-05 Macrogenics Inc FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF
EP1553975B8 (en) 2002-09-27 2023-04-12 Xencor, Inc. Optimized fc variants and methods for their generation
DK1562972T3 (da) 2002-10-15 2010-12-06 Facet Biotech Corp Modifikation af FcRn-bindingsaffiniteter eller serumhalveringstider for antistoffer ved mutagenese
CA2512729C (en) 2003-01-09 2014-09-16 Macrogenics, Inc. Identification and engineering of antibodies with variant fc regions and methods of using same
EP1588166A4 (en) 2003-01-09 2007-06-27 Macrogenics Inc VECTOR SYSTEM WITH DOUBLE EXPRESSION FOR EXPRESSING ANTIBODIES IN BACTERIAL AND MAMMAL CELLS
CA2512974A1 (en) 2003-01-13 2004-07-29 Macrogenics, Inc. Soluble fc.gamma.r fusion proteins and methods of use thereof
DK2236154T3 (en) * 2003-02-10 2018-06-25 Biogen Ma Inc IMMUNOGLOBULIN INFORMATION AND METHOD OF PREPARING IT
US7662928B2 (en) 2003-08-08 2010-02-16 The Research Foundation Of State University Of New York Anti-FcRn antibodies for treatment of auto/allo immune conditions
GB0324368D0 (en) 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
EP1798864A4 (en) 2004-09-30 2013-07-31 Brother Ind Ltd WIRELESS LABEL COMMUNICATION DEVICE, WIRELESS LABEL, WIRELESS COMMUNICATION SYSTEM AND METHOD OF WIRELESS COMMUNICATION
CA2606378A1 (en) 2005-04-29 2006-11-09 The Jackson Laboratory Fcrn antibodies and uses thereof
WO2006130834A2 (en) 2005-05-31 2006-12-07 Board Of Regents, The University Of Texas System IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
EP2144930A1 (en) 2007-04-18 2010-01-20 ZymoGenetics, Inc. Single chain fc, methods of making and methods of treatment
EP2158318A2 (en) 2007-05-14 2010-03-03 Biogen Idec MA, Inc. Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
PL2185589T3 (pl) 2007-06-01 2016-09-30 Środki wiążące receptor regionu stałego Fc immunoglobuliny
US8935381B2 (en) 2007-11-27 2015-01-13 Zettics, Inc. Method and apparatus for real-time collection of information about application level activity and other user information on a mobile data network
WO2009100105A2 (en) 2008-02-04 2009-08-13 Attogen Inc. Inhibitors of oncogenic isoforms and uses thereof
US9260525B2 (en) 2008-02-04 2016-02-16 Xiao-Jia Chang Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof
WO2009131702A2 (en) 2008-04-25 2009-10-29 Dyax Corp. Antibodies against fcrn and use thereof
WO2010014909A1 (en) 2008-08-01 2010-02-04 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
EP2233500A1 (en) 2009-03-20 2010-09-29 LFB Biotechnologies Optimized Fc variants
JP5898082B2 (ja) 2009-10-07 2016-04-06 マクロジェニクス,インコーポレーテッド フコシル化程度の変更により改良されたエフェクター機能を示すFc領域含有ポリペプチドおよびその使用法
BR112012013148A2 (pt) * 2009-12-29 2017-03-21 F Hoffmann - La Roche Ag formulação farmacêutica e uso
GB201111291D0 (en) 2011-06-30 2011-08-17 Agco Int Gmbh Engine control system
AU2012328819B2 (en) 2011-10-26 2017-08-03 Elanco Tiergesundheit Ag Monoclonal antibodies and methods of use
US20140302028A1 (en) 2011-11-18 2014-10-09 Merck Sharp & Dohme Corp. Fc containing polypeptides having increased anti-inflammatory properties and increased fcrn binding
KR102041412B1 (ko) 2011-12-30 2019-11-11 한미사이언스 주식회사 면역글로불린 Fc 단편 유도체
GB201208370D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
US9803191B2 (en) 2012-07-05 2017-10-31 Genentech, Inc. Expression and secretion system
KR101815265B1 (ko) 2013-06-20 2018-01-04 한올바이오파마주식회사 FcRn 특이적 인간 항체 및 이를 포함하는 자가면역 질환 치료용 조성물
WO2015081073A2 (en) 2013-11-26 2015-06-04 The Brigham And Women's Hospital, Inc. Compositions and methods for modulating an immune response
SG11201605203UA (en) * 2013-12-24 2016-07-28 Argen X N V Fcrn antagonists and methods of use
PL3193930T3 (pl) 2014-09-17 2019-12-31 Affibody Ab Nowe polipeptydy
RS64768B1 (sr) 2015-01-30 2023-11-30 Momenta Pharmaceuticals Inc Fcrn antitela i načini njihove upotrebe
CA2978253A1 (en) 2015-03-09 2016-09-15 Argenx Bvba Methods of reducing serum levels of fc-containing agents using fcrn antagonists
EP3294335B1 (en) 2015-05-12 2023-07-05 Syntimmune Inc. Humanized affinity matured anti-fcrn antibodies
GB201508180D0 (en) 2015-05-13 2015-06-24 Ucb Biopharma Sprl Antibodies
EP3325004A1 (en) 2015-07-17 2018-05-30 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and pharmaceutical compositions for inducing immune tolerance by mucosal vaccination with fc-coupled antigens
GB201618424D0 (en) 2016-11-01 2016-12-14 Argenix Bvba Treatment of antibody mediated disease
CA3081144A1 (en) 2017-12-08 2019-06-13 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
US12202900B2 (en) 2018-06-08 2025-01-21 argenx BV Compositions and methods for treating immune thrombocytopenia
EP3969125A4 (en) 2019-05-17 2023-01-11 Alexion Pharmaceuticals, Inc. USE OF ANTI-FCRN ANTIBODIES IN THE TREATMENT OF PEMPHIGHUS AND PEMPHIGOID DISEASES

Similar Documents

Publication Publication Date Title
JP2025000867A5 (https=)
US20260015415A1 (en) Pharmaceutical formulations of fcrn inhibitors suitable for subcutaneous administration
JP2022105084A5 (https=)
CA3258002A1 (en) FCRN BINDING MOLECULES AND METHODS OF USE
US20210403593A1 (en) Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies
JP2022528927A5 (https=)
ES2664619T3 (es) Polipéptidos de anticuerpos que antagonizan CD40
JP2017501725A5 (https=)
RU2014117511A (ru) CD40L-СПЕЦИФИЧНЫЕ КАРКАСНЫЕ СТРУКТУРЫ, ПРОИСХОДЯЩИЕ ИЗ Tn3, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
ES2768614T3 (es) Formulaciones de anticuerpos anti-PDL1
JP2015501147A5 (https=)
JP2018509413A5 (https=)
JP2024530152A5 (https=)
JP2025520420A5 (https=)
BRPI0608855A2 (pt) composições de anticorpo anti - madcam processo para a preparação das mesmas e uso de anticorpo anti - madcam
JP2025504815A5 (https=)
JP2016527187A5 (https=)
CN108473571B (zh) 结合人Fc受体的融合蛋白
US20250034230A1 (en) Regulatory t cells targeted by lymphotoxin alpha blocking agent and uses thereof
TW202222342A (zh) 適用於皮下施用的FcRn抑制劑的藥物製劑
HK40062227A (en) Pharmaceutical formulations of fcrn inhibitors suitable for subcutaneous administration
NZ734416A (en) Methods of reducing serum levels of fc-containing agents using fcrn antagonists
NZ773089B2 (en) Methods of reducing serum levels of fc-containing agents using fcrn antagonists
NZ773089A (en) Methods of reducing serum levels of fc-containing agents using fcrn antagonists
RU2023135361A (ru) Белки, которые связываются с cd80 и/или cd86 и ox40l