JP2024545233A5 - - Google Patents
Info
- Publication number
- JP2024545233A5 JP2024545233A5 JP2024535725A JP2024535725A JP2024545233A5 JP 2024545233 A5 JP2024545233 A5 JP 2024545233A5 JP 2024535725 A JP2024535725 A JP 2024535725A JP 2024535725 A JP2024535725 A JP 2024535725A JP 2024545233 A5 JP2024545233 A5 JP 2024545233A5
- Authority
- JP
- Japan
- Prior art keywords
- structural formula
- compound represented
- prodrug
- compound
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111544686.7 | 2021-12-16 | ||
| CN202111544686 | 2021-12-16 | ||
| PCT/CN2022/139765 WO2023109965A1 (zh) | 2021-12-16 | 2022-12-16 | 一种喜树碱类化合物及其偶联物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024545233A JP2024545233A (ja) | 2024-12-05 |
| JP2024545233A5 true JP2024545233A5 (https=) | 2025-12-24 |
Family
ID=86774914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024535725A Pending JP2024545233A (ja) | 2021-12-16 | 2022-12-16 | カンプトテシン化合物及びそのコンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250059201A1 (https=) |
| EP (1) | EP4450506A4 (https=) |
| JP (1) | JP2024545233A (https=) |
| KR (1) | KR20240120744A (https=) |
| CN (2) | CN116813631A (https=) |
| AU (1) | AU2022408887A1 (https=) |
| CA (1) | CA3241157A1 (https=) |
| MX (1) | MX2024007498A (https=) |
| WO (1) | WO2023109965A1 (https=) |
| ZA (1) | ZA202405368B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023083381A1 (zh) | 2021-11-15 | 2023-05-19 | 成都百利多特生物药业有限责任公司 | 双特异性抗体-喜树碱类药物偶联物及其医药用途 |
| CA3261603A1 (en) * | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | ANTIBODY-DRUG CONJUGATES |
| WO2024097812A1 (en) * | 2022-11-04 | 2024-05-10 | Gilead Sciences, Inc. | Therapy for treating bladder cancer |
| WO2024193682A1 (en) * | 2023-03-23 | 2024-09-26 | Xadcera Biopharmaceutical (Suzhou) Co., Ltd. | Anti-tpbg/met antibodies and uses thereof |
| KR20260020468A (ko) * | 2023-06-05 | 2026-02-11 | 장쑤 맵웰 헬스 파마수티컬 알앤디 컴퍼니, 리미티드 | 항-b7-h3 항체 또는 그 단편 및 b7-h3를 표적으로 하는 항체 약물 접합체(anti-b7-h3 antibody or fragment thereof, and antibody drug conjugate targeting b7-h3) |
| CN121399134A (zh) * | 2023-10-10 | 2026-01-23 | 上海翊维康医药有限责任公司 | 新的i型拓扑异构酶抑制剂及其制备方法和用途 |
| WO2025106278A1 (en) | 2023-11-17 | 2025-05-22 | Mersana Therapeutics, Inc. | Treatment of cancer using b7-h4-targeted antibody-drug conjugates |
| WO2025140662A1 (en) * | 2023-12-29 | 2025-07-03 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-egfr/her3 antibodies and uses thereof |
| WO2025149019A1 (en) * | 2024-01-12 | 2025-07-17 | Shanghai Ruotuo Biosciences Co., Ltd. | Antibody-drug conjugates, pharmaceutical compositions, and therapeutic applications |
| CN120437319A (zh) * | 2024-02-07 | 2025-08-08 | 长春金赛药业有限责任公司 | 带有连接系统的抗体药物偶联物 |
| WO2025191470A1 (en) * | 2024-03-12 | 2025-09-18 | Astrazeneca Ab | Processes and compounds for the preparation of topoisomerase i inhibitor linker-payloads |
| CN121130102A (zh) * | 2024-06-14 | 2025-12-16 | 长春金赛药业有限责任公司 | 靶向b7-h3和psma的双特异性抗体及抗体-药物偶联物 |
| WO2025261469A1 (zh) * | 2024-06-20 | 2025-12-26 | 科霸生物（江苏）有限公司 | 喜树碱衍生物、抗体、药物偶联物、及其组合物和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| JP3359955B2 (ja) * | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
| US6136978A (en) * | 1993-06-30 | 2000-10-24 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| GB9512670D0 (en) * | 1995-06-21 | 1995-08-23 | Sod Conseils Rech Applic | Camptothecin analogues |
| US6207832B1 (en) * | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US7067666B2 (en) | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| DE102005009099A1 (de) * | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | Proteinbindende Camptothecin-Peptid-Derivate und diese enthaltende Arzneimittel |
| ES2773710T3 (es) * | 2012-10-11 | 2020-07-14 | Daiichi Sankyo Co Ltd | Enlazadores para conjugados de anticuerpo - fármaco |
| CN107753954A (zh) | 2012-12-13 | 2018-03-06 | 免疫医疗公司 | 功效改进且毒性降低的抗体与sn‑38的免疫缀合物的剂量 |
| AU2014371934B2 (en) | 2013-12-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Anti-TROP2 antibody-drug conjugate |
| IL310627B2 (en) | 2014-01-31 | 2026-04-01 | Daiichi Sankyo Co Ltd | Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof |
| KR102445502B1 (ko) | 2014-04-10 | 2022-09-21 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
| JP6948708B2 (ja) * | 2015-06-19 | 2021-10-13 | センチュリオン バイオファーマ コーポレイション | 薬物制御放出のための送達系 |
| CN106349233B (zh) | 2015-07-15 | 2021-06-01 | 上海翰森生物医药科技有限公司 | 3,4-二苯基-4h-1,2,4-三唑衍生物及其制备方法和应用 |
| CN108101825B (zh) * | 2016-11-25 | 2022-02-22 | 迈威(上海)生物科技股份有限公司 | 用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途 |
| CA3044898C (en) | 2016-11-25 | 2022-04-05 | Mabwell (shanghai) Bioscience Co., Ltd. | Di-substituted maleic amide linker for antibody-drug conjugating and preparation method and use thereof |
| WO2020063676A1 (zh) * | 2018-09-26 | 2020-04-02 | 江苏恒瑞医药股份有限公司 | 依喜替康类似物的配体-药物偶联物及其制备方法和应用 |
| MX2021011812A (es) * | 2019-03-29 | 2021-10-22 | Medimmune Ltd | Compuestos y conjugados de estos. |
| TW202140076A (zh) | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | 化合物及其軛合物 |
| EP4093439A1 (en) * | 2020-01-22 | 2022-11-30 | MedImmune Limited | Compounds and conjugates thereof |
| IL308734A (en) * | 2021-05-27 | 2024-01-01 | Zymeworks Bc Inc | Camptothecin analogues, conjugates and methods of use |
-
2022
- 2022-12-16 CA CA3241157A patent/CA3241157A1/en active Pending
- 2022-12-16 AU AU2022408887A patent/AU2022408887A1/en active Pending
- 2022-12-16 US US18/720,569 patent/US20250059201A1/en active Pending
- 2022-12-16 JP JP2024535725A patent/JP2024545233A/ja active Pending
- 2022-12-16 KR KR1020247023132A patent/KR20240120744A/ko active Pending
- 2022-12-16 CN CN202211627164.8A patent/CN116813631A/zh active Pending
- 2022-12-16 MX MX2024007498A patent/MX2024007498A/es unknown
- 2022-12-16 WO PCT/CN2022/139765 patent/WO2023109965A1/zh not_active Ceased
- 2022-12-16 EP EP22906709.5A patent/EP4450506A4/en active Pending
- 2022-12-16 CN CN202280083630.2A patent/CN118414339A/zh active Pending
-
2024
- 2024-07-10 ZA ZA2024/05368A patent/ZA202405368B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024545233A5 (https=) | ||
| JP2023535598A5 (https=) | ||
| JP2022537158A5 (https=) | ||
| JP6743015B2 (ja) | Ｋｓｐ阻害剤の脱グリコシル化抗ｔｗｅａｋｒ抗体との抗体薬物複合体（ａｄｃ類） | |
| JP2018524313A (ja) | キネシンスピンドルタンパク質（ｋｓｐ）阻害剤の抗ｂ７ｈ３抗体との抗体薬物複合体 | |
| WO2022020288A1 (en) | Antibody-conjugated chemical inducers of degradation of brm and methods thereof | |
| CN119136840A (zh) | 喜树碱类衍生物及配体-药物偶联物 | |
| JP2025148380A (ja) | 抗体－薬物コンジュゲート及びそれらの使用 | |
| JP2025513163A (ja) | 抗体－薬物コンジュゲート、その医薬組成物及びその使用 | |
| JP2025516873A (ja) | タンパク質分解剤クラスの生物学的活性化合物を含む抗体薬物複合体及びその調製方法並びに使用 | |
| JP2023553808A5 (https=) | ||
| JP2024523422A (ja) | 抗腫瘍化合物およびその応用 | |
| TWI775203B (zh) | 製備環縮肽之方法 | |
| JP2021525265A5 (https=) | ||
| CN120957761A (zh) | 具有靶向作用的偶联物及其制备方法和用途 | |
| JPWO2020166592A1 (ja) | ヘミアスタリン誘導体とその抗体薬物複合体 | |
| JP2024501453A5 (https=) | ||
| WO2021013693A1 (en) | Antibody drug conjugates (adcs) with nampt inhibitors | |
| CN120957755A (zh) | 多环类药物偶联物及其制备方法和用途 | |
| RU2024119888A (ru) | Соединение на основе камптотецина и его конъюгат | |
| SI9300567A (en) | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | |
| CN120957756A (zh) | 稠环化合物及其制备方法和用途 | |
| CN119455000A (zh) | 一类三嗪化合物、其偶联物、制备方法及用途 | |
| RU2024138377A (ru) | Конъюгаты антитело-лекарственное средство, являющиеся ингибиторами met bcl-xl, и способы их применения | |
| CA3256942A1 (en) | Camptothecin derivative and ligand-drug conjugate |