JP2024543983A5 - - Google Patents

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Publication number
JP2024543983A5
JP2024543983A5 JP2024532556A JP2024532556A JP2024543983A5 JP 2024543983 A5 JP2024543983 A5 JP 2024543983A5 JP 2024532556 A JP2024532556 A JP 2024532556A JP 2024532556 A JP2024532556 A JP 2024532556A JP 2024543983 A5 JP2024543983 A5 JP 2024543983A5
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JP
Japan
Prior art keywords
alkyl
group
membered
hydrogen
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024532556A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024543983A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2022/083936 external-priority patent/WO2023099612A1/en
Publication of JP2024543983A publication Critical patent/JP2024543983A/ja
Publication of JP2024543983A5 publication Critical patent/JP2024543983A5/ja
Pending legal-status Critical Current

Links

JP2024532556A 2021-12-01 2022-11-30 がんの処置のための縮環2-アミノ-3-シアノチオフェン及び誘導体 Pending JP2024543983A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163284778P 2021-12-01 2021-12-01
US63/284,778 2021-12-01
PCT/EP2022/083936 WO2023099612A1 (en) 2021-12-01 2022-11-30 Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2024543983A JP2024543983A (ja) 2024-11-26
JP2024543983A5 true JP2024543983A5 (https=) 2025-11-28

Family

ID=84536000

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024532556A Pending JP2024543983A (ja) 2021-12-01 2022-11-30 がんの処置のための縮環2-アミノ-3-シアノチオフェン及び誘導体

Country Status (6)

Country Link
US (1) US20250296940A1 (https=)
EP (1) EP4441053A1 (https=)
JP (1) JP2024543983A (https=)
CN (2) CN118574835A (https=)
TW (1) TW202340209A (https=)
WO (1) WO2023099612A1 (https=)

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Publication number Priority date Publication date Assignee Title
EP4067343A4 (en) 2019-11-29 2024-01-03 Taiho Pharmaceutical Co., Ltd. NEW PHENOLIC COMPOUND OR SALT THEREOF
JP7808058B2 (ja) 2020-06-02 2026-01-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング がんを治療するための縮合環化2-アミノ-3-シアノチオフェン及び誘導体
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
WO2023099624A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
CA3243798A1 (en) 2022-02-09 2023-08-17 Quanta Therapeutics, Inc. Kras Modulators and Their Uses
WO2023230190A1 (en) 2022-05-25 2023-11-30 Quanta Therapeutics, Inc. Pyrimidine based modulators and uses thereof
KR20260041941A (ko) 2023-03-15 2026-03-27 콴타 테라퓨틱스, 인크. Kras 조절 인자 및 이의 용도
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ras相關疾病或病症之組合療法
WO2024246099A1 (en) * 2023-05-30 2024-12-05 Boehringer Ingelheim International Gmbh Spirocyclic annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2024255795A1 (en) * 2023-06-14 2024-12-19 Insilico Medicine Ip Limited Kras inhibitors and uses thereof
WO2025016899A1 (en) 2023-07-19 2025-01-23 Bayer Aktiengesellschaft Spirocyclic compounds for the treatment of cancer
WO2025026903A1 (en) 2023-07-31 2025-02-06 Bayer Aktiengesellschaft Imidazo pyrimidine compounds for the treatment of cancer
CN121620514A (zh) 2023-08-02 2026-03-06 耐瑞欧医疗公司 蛋白质酪氨酸磷酸酶降解剂及其用途
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AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
AU2024361909A1 (en) 2023-10-20 2026-03-26 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
US20250205238A1 (en) 2023-12-20 2025-06-26 Boehringer Ingelheim International Gmbh Anti-cancer combination therapy
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CN117924327A (zh) * 2024-01-24 2024-04-26 上海湃隆生物科技有限公司 具有大环结构的Kras抑制剂化合物
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025190158A1 (zh) * 2024-03-14 2025-09-18 四川科伦博泰生物医药股份有限公司 螺环化合物、其制备方法及用途
WO2025190342A1 (zh) * 2024-03-15 2025-09-18 苏州浦合医药科技有限公司 螺环化合物作为kras突变体抑制剂
WO2025201480A1 (zh) * 2024-03-28 2025-10-02 苏州浦合医药科技有限公司 螺环化合物作为kras突变体抑制剂
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ras抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025261393A1 (en) * 2024-06-19 2025-12-26 Insilico Medicine Ip Limited Novel compounds as kras inhibitors and uses thereof
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026007740A1 (zh) * 2024-07-04 2026-01-08 四川科伦博泰生物医药股份有限公司 螺环化合物、其制备方法及用途
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015785A1 (en) * 2024-07-12 2026-01-15 Blossomhill Therapeutics, Inc. Spirocyclic kras inhibitors for treating disease
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026035945A1 (en) 2024-08-07 2026-02-12 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a topoisomerase payload
WO2026035947A1 (en) 2024-08-07 2026-02-12 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a topoisomerase payload
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026064520A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload
WO2026064527A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
CN119751476B (zh) * 2025-03-05 2025-06-03 苏州共康医药科技有限公司 螺环类化合物及其在医药上的应用

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PT3886991T (pt) * 2019-12-11 2022-10-17 Lilly Co Eli Inibidores de kras g12c
UY39129A (es) 2020-03-16 2021-10-29 Novartis Ag Derivados de biarilo como inhibidores de la interacción proteína-proteína de yap/taz-tead
JP7808058B2 (ja) 2020-06-02 2026-01-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング がんを治療するための縮合環化2-アミノ-3-シアノチオフェン及び誘導体

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