CN118574835A - 用于治疗癌症的环状2-氨基-3-氰基噻吩及衍生物 - Google Patents

用于治疗癌症的环状2-氨基-3-氰基噻吩及衍生物 Download PDF

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Publication number
CN118574835A
CN118574835A CN202280089341.3A CN202280089341A CN118574835A CN 118574835 A CN118574835 A CN 118574835A CN 202280089341 A CN202280089341 A CN 202280089341A CN 118574835 A CN118574835 A CN 118574835A
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CN
China
Prior art keywords
alkyl
group
hydrogen
membered heterocyclyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280089341.3A
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English (en)
Chinese (zh)
Inventor
J·布罗克
J·艾布特
崔剑文
S·W·菲西克
J·福斯
A·戈尔纳
L·赫德斯
T·霍奇斯
A·利特尔
A·曼图利迪斯
J·潘
D·萨尔卡
C·A·P·斯姆瑟斯特
孙琪
A·瓦特森
T·温伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Vanderbilt University
Original Assignee
Boehringer Ingelheim International GmbH
Vanderbilt University
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Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Vanderbilt University filed Critical Boehringer Ingelheim International GmbH
Publication of CN118574835A publication Critical patent/CN118574835A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202280089341.3A 2021-12-01 2022-11-30 用于治疗癌症的环状2-氨基-3-氰基噻吩及衍生物 Pending CN118574835A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163284778P 2021-12-01 2021-12-01
US63/284,778 2021-12-01
PCT/EP2022/083936 WO2023099612A1 (en) 2021-12-01 2022-11-30 Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

Publications (1)

Publication Number Publication Date
CN118574835A true CN118574835A (zh) 2024-08-30

Family

ID=84536000

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202280089341.3A Pending CN118574835A (zh) 2021-12-01 2022-11-30 用于治疗癌症的环状2-氨基-3-氰基噻吩及衍生物
CN202280078499.0A Pending CN118647620A (zh) 2021-12-01 2022-11-30 用于治疗癌症的环状2-氨基-3-氰基噻吩及其衍生物

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CN202280078499.0A Pending CN118647620A (zh) 2021-12-01 2022-11-30 用于治疗癌症的环状2-氨基-3-氰基噻吩及其衍生物

Country Status (6)

Country Link
US (1) US20250296940A1 (https=)
EP (1) EP4441053A1 (https=)
JP (1) JP2024543983A (https=)
CN (2) CN118574835A (https=)
TW (1) TW202340209A (https=)
WO (1) WO2023099612A1 (https=)

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CN117924327A (zh) * 2024-01-24 2024-04-26 上海湃隆生物科技有限公司 具有大环结构的Kras抑制剂化合物
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WO2025190342A1 (zh) * 2024-03-15 2025-09-18 苏州浦合医药科技有限公司 螺环化合物作为kras突变体抑制剂
WO2025201480A1 (zh) * 2024-03-28 2025-10-02 苏州浦合医药科技有限公司 螺环化合物作为kras突变体抑制剂
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119751476A (zh) * 2025-03-05 2025-04-04 苏州共康医药科技有限公司 螺环类化合物及其在医药上的应用

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US20250296940A1 (en) 2025-09-25
JP2024543983A (ja) 2024-11-26
WO2023099612A1 (en) 2023-06-08
CN118647620A (zh) 2024-09-13
EP4441053A1 (en) 2024-10-09
TW202340209A (zh) 2023-10-16

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