JP2024542260A5 - - Google Patents
Info
- Publication number
- JP2024542260A5 JP2024542260A5 JP2024530522A JP2024530522A JP2024542260A5 JP 2024542260 A5 JP2024542260 A5 JP 2024542260A5 JP 2024530522 A JP2024530522 A JP 2024530522A JP 2024530522 A JP2024530522 A JP 2024530522A JP 2024542260 A5 JP2024542260 A5 JP 2024542260A5
- Authority
- JP
- Japan
- Prior art keywords
- branched
- independently
- unbranched
- compound according
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163264420P | 2021-11-22 | 2021-11-22 | |
| US202163264400P | 2021-11-22 | 2021-11-22 | |
| US63/264,420 | 2021-11-22 | ||
| US63/264,400 | 2021-11-22 | ||
| US202263322952P | 2022-03-23 | 2022-03-23 | |
| US63/322,952 | 2022-03-23 | ||
| PCT/US2022/050725 WO2023091787A1 (en) | 2021-11-22 | 2022-11-22 | Novel ionizable lipids and lipid nanoparticles and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024542260A JP2024542260A (ja) | 2024-11-13 |
| JP2024542260A5 true JP2024542260A5 (https=) | 2025-11-28 |
Family
ID=84888584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024530522A Pending JP2024542260A (ja) | 2021-11-22 | 2022-11-22 | 新規イオン化可能な脂質および脂質ナノ粒子ならびにそれらを使用する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250051263A1 (https=) |
| EP (1) | EP4436549A1 (https=) |
| JP (1) | JP2024542260A (https=) |
| KR (1) | KR20240128683A (https=) |
| AU (1) | AU2022391677A1 (https=) |
| CA (1) | CA3238758A1 (https=) |
| MX (1) | MX2024006134A (https=) |
| WO (1) | WO2023091787A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250353809A1 (en) * | 2022-06-06 | 2025-11-20 | Shanghai Rnacure Biopharma Co., Ltd. | Nitrogen-containing chain compound, preparation method, composition containing said compound, and use thereof |
| WO2024136309A1 (en) * | 2022-12-23 | 2024-06-27 | Green Cross Corporation | Ionizable lipid and use thereof |
| US20260116844A1 (en) * | 2022-12-29 | 2026-04-30 | SurgiNex Co., Ltd. | Lipid nanoparticle formulation comprising ionized lipids with branched structure, and use thereof |
| CN116178193B (zh) * | 2023-01-05 | 2023-07-28 | 北京悦康科创医药科技股份有限公司 | 高效低毒且稳定性表达的阳离子脂质化合物及其组合物 |
| CN121057577A (zh) * | 2023-01-27 | 2025-12-02 | 赛欧生物医药股份有限公司 | 经修饰的脂质组合物及其用途 |
| EP4673116A1 (en) * | 2023-02-28 | 2026-01-07 | Agency for Science, Technology and Research | A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2024253582A1 (en) * | 2023-06-06 | 2024-12-12 | Agency For Science, Technology And Research | A nanoparticle composition and related methods thereof |
| WO2025042786A1 (en) | 2023-08-18 | 2025-02-27 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| AR134145A1 (es) * | 2023-10-24 | 2025-12-03 | Green Cross Corp | Lípidos ionizables y sus usos |
| US12599560B2 (en) | 2023-11-02 | 2026-04-14 | Longuide Biopharma Corporation | Lipids and lipid nanoparticle formulations |
| CN121015605A (zh) * | 2024-01-19 | 2025-11-28 | 晟迪生物医药(苏州)有限公司 | 含有可电离脂质的肺部递送系统、其制备方法和应用 |
| TW202543585A (zh) | 2024-03-08 | 2025-11-16 | 美商健臻公司 | 脂質奈米粒子 |
| WO2025209444A1 (zh) * | 2024-04-02 | 2025-10-09 | 南京奥罗生物科技有限公司 | 可电离脂质化合物、包含其的脂质纳米颗粒及其应用 |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US907699A (en) | 1906-04-24 | 1908-12-22 | William D Moore | Building-block. |
| JPS58500845A (ja) | 1981-06-04 | 1983-05-26 | デラウェア・ケミカルス・コーポレーション | ポンプ |
| US4778810A (en) | 1987-01-08 | 1988-10-18 | Nastech Pharmaceutical Co., Inc. | Nasal delivery of caffeine |
| US6197553B1 (en) | 1994-07-15 | 2001-03-06 | Merck & Co., Inc. | Method for large scale plasmid purification |
| US5965542A (en) | 1997-03-18 | 1999-10-12 | Inex Pharmaceuticals Corp. | Use of temperature to control the size of cationic liposome/plasmid DNA complexes |
| US6410328B1 (en) | 1998-02-03 | 2002-06-25 | Protiva Biotherapeutics Inc. | Sensitizing cells to compounds using lipid-mediated gene and compound delivery |
| CA2321837C (en) | 1998-02-03 | 2011-08-16 | Inex Pharmaceuticals Corporation | Systemic delivery of serum stable plasmid lipid particles for cancer therapy |
| US6211140B1 (en) | 1999-07-26 | 2001-04-03 | The Procter & Gamble Company | Cationic charge boosting systems |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| CA2532228C (en) | 2003-07-16 | 2017-02-14 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| US6927663B2 (en) | 2003-07-23 | 2005-08-09 | Cardiac Pacemakers, Inc. | Flyback transformer wire attach method to printed circuit board |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| CA2569664C (en) | 2004-06-07 | 2013-07-16 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| JP4764426B2 (ja) | 2004-06-07 | 2011-09-07 | プロチバ バイオセラピューティクス インコーポレイティッド | カチオン性脂質および使用方法 |
| CN101267805A (zh) | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| CN111808084A (zh) | 2008-11-10 | 2020-10-23 | 阿布特斯生物制药公司 | 用于递送治疗剂的新型脂质和组合物 |
| WO2011000107A1 (en) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| US8569256B2 (en) | 2009-07-01 | 2013-10-29 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| WO2011066651A1 (en) | 2009-12-01 | 2011-06-09 | Protiva Biotherapeutics, Inc. | Snalp formulations containing antioxidants |
| EP3296398A1 (en) | 2009-12-07 | 2018-03-21 | Arbutus Biopharma Corporation | Compositions for nucleic acid delivery |
| EP3494963A1 (en) | 2009-12-18 | 2019-06-12 | The University of British Columbia | Methods and compositions for delivery of nucleic acids |
| US20130123338A1 (en) | 2010-05-12 | 2013-05-16 | Protiva Biotherapeutics, Inc. | Novel cationic lipids and methods of use thereof |
| KR20190039347A (ko) | 2010-06-03 | 2019-04-10 | 알닐람 파마슈티칼스 인코포레이티드 | 활성제의 전달을 위한 생분해성 지질 |
| WO2012016184A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| US8466122B2 (en) | 2010-09-17 | 2013-06-18 | Protiva Biotherapeutics, Inc. | Trialkyl cationic lipids and methods of use thereof |
| CA2824526C (en) | 2011-01-11 | 2020-07-07 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| WO2013016058A1 (en) | 2011-07-22 | 2013-01-31 | Merck Sharp & Dohme Corp. | Novel bis-nitrogen containing cationic lipids for oligonucleotide delivery |
| EP3456317B1 (en) | 2011-09-27 | 2025-09-24 | Alnylam Pharmaceuticals, Inc. | Di-aliphatic substituted pegylated lipids |
| US8762704B2 (en) | 2011-09-29 | 2014-06-24 | Apple Inc. | Customized content for electronic devices |
| AU2012347605B2 (en) | 2011-12-07 | 2017-09-21 | Alnylam Pharmaceuticals, Inc. | Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents |
| WO2013086373A1 (en) | 2011-12-07 | 2013-06-13 | Alnylam Pharmaceuticals, Inc. | Lipids for the delivery of active agents |
| WO2013086354A1 (en) | 2011-12-07 | 2013-06-13 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2014008334A1 (en) | 2012-07-06 | 2014-01-09 | Alnylam Pharmaceuticals, Inc. | Stable non-aggregating nucleic acid lipid particle formulations |
| HUE060907T2 (hu) | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére |
| PT3313829T (pt) | 2015-06-29 | 2024-07-08 | Acuitas Therapeutics Inc | Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| WO2017117528A1 (en) | 2015-12-30 | 2017-07-06 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| WO2019036028A1 (en) * | 2017-08-17 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS |
| CN118697900A (zh) | 2019-01-31 | 2024-09-27 | 摩登纳特斯有限公司 | 制备脂质纳米颗粒的方法 |
-
2022
- 2022-11-22 JP JP2024530522A patent/JP2024542260A/ja active Pending
- 2022-11-22 US US18/712,100 patent/US20250051263A1/en active Pending
- 2022-11-22 MX MX2024006134A patent/MX2024006134A/es unknown
- 2022-11-22 WO PCT/US2022/050725 patent/WO2023091787A1/en not_active Ceased
- 2022-11-22 AU AU2022391677A patent/AU2022391677A1/en active Pending
- 2022-11-22 CA CA3238758A patent/CA3238758A1/en active Pending
- 2022-11-22 EP EP22839933.3A patent/EP4436549A1/en active Pending
- 2022-11-22 KR KR1020247020738A patent/KR20240128683A/ko active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024542260A5 (https=) | ||
| JP2024542188A5 (https=) | ||
| JP7594038B2 (ja) | Ｒｎａ送達のためのイオン化可能なカチオン性脂質 | |
| JP2024546952A5 (https=) | ||
| US9365610B2 (en) | Asymmetric ionizable cationic lipid for RNA delivery | |
| JP2023541427A (ja) | 骨格筋送達プラットフォーム及び使用方法 | |
| JP2024546951A5 (https=) | ||
| WO2018119163A1 (en) | Ionizable cationic lipid for rna delivery | |
| EP3221293A1 (en) | Ionizable cationic lipid for rna delivery | |
| JP2022533069A5 (https=) | ||
| JP2023541415A (ja) | 治療薬の送達用脂質複合体 | |
| JP2023538524A5 (https=) | ||
| JP2022087209A (ja) | Ｂ型肝炎を治療するための治療用組成物及び方法 | |
| JP2023513698A5 (https=) | ||
| JP2023518944A5 (https=) | ||
| CN115702005A (zh) | 用于有效核酸递送的载体 | |
| CN117897152A (zh) | 含有糖官能化核酸载体的纳米颗粒组合物 | |
| RU2004121776A (ru) | Производные тетрагидрокарбазола, способ получения производных тетрагидрокарбазола (варианты), их применение (варианты) и фармацевтическая композиция, обладающая активностью антагониста гонадотропин-рилизинг-гормона (варианты) | |
| JP2024512770A (ja) | 遺伝子送達における非ウイルスベクターとしての樹状構造 | |
| WO2011139343A2 (en) | Amino acid linked peg-lipid conjugates | |
| JP2023540806A (ja) | 骨格筋への送達プラットフォームおよび使用の方法 | |
| CN116490214A (zh) | 骨骼肌递送平台及使用方法 | |
| JP2023533452A5 (https=) | ||
| US20260078086A1 (en) | Versatile biodegradable molecules as nucleic acid carriers | |
| WO2024094098A1 (zh) | 一种用于递送系统的化合物及其用途 |