AU2022391677A1 - Novel ionizable lipids and lipid nanoparticles and methods of using the same - Google Patents

Novel ionizable lipids and lipid nanoparticles and methods of using the same Download PDF

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AU2022391677A1
AU2022391677A1 AU2022391677A AU2022391677A AU2022391677A1 AU 2022391677 A1 AU2022391677 A1 AU 2022391677A1 AU 2022391677 A AU2022391677 A AU 2022391677A AU 2022391677 A AU2022391677 A AU 2022391677A AU 2022391677 A1 AU2022391677 A1 AU 2022391677A1
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compound
lipid
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branched
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Arijit ADHIKARI
Alessandra Bartolozzi
Roman Erdmann
Alaina HOWE
Siddharth Patel
John Proudfoot
Dominick SALERNO
Jennifer UNION
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Sail Biomedicines Inc
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Sail Biomedicines Inc
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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
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    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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AU2022391677A 2021-11-22 2022-11-22 Novel ionizable lipids and lipid nanoparticles and methods of using the same Pending AU2022391677A1 (en)

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US202163264420P 2021-11-22 2021-11-22
US202163264400P 2021-11-22 2021-11-22
US63/264,420 2021-11-22
US63/264,400 2021-11-22
US202263322952P 2022-03-23 2022-03-23
US63/322,952 2022-03-23
PCT/US2022/050725 WO2023091787A1 (en) 2021-11-22 2022-11-22 Novel ionizable lipids and lipid nanoparticles and methods of using the same

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KR (1) KR20240128683A (https=)
AU (1) AU2022391677A1 (https=)
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TW202543585A (zh) 2024-03-08 2025-11-16 美商健臻公司 脂質奈米粒子
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