JP2024540692A5 - - Google Patents
Info
- Publication number
- JP2024540692A5 JP2024540692A5 JP2024549577A JP2024549577A JP2024540692A5 JP 2024540692 A5 JP2024540692 A5 JP 2024540692A5 JP 2024549577 A JP2024549577 A JP 2024549577A JP 2024549577 A JP2024549577 A JP 2024549577A JP 2024540692 A5 JP2024540692 A5 JP 2024540692A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- conjugate according
- alkyl
- substituted aromatic
- aromatic residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21207284.7 | 2021-11-09 | ||
| EP21207284 | 2021-11-09 | ||
| PCT/EP2022/081371 WO2023083919A1 (en) | 2021-11-09 | 2022-11-09 | Conjugates comprising a phosphorus (v) and a camptothecin moiety |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024540692A JP2024540692A (ja) | 2024-10-31 |
| JP2024540692A5 true JP2024540692A5 (enExample) | 2025-11-17 |
Family
ID=78592674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024549577A Pending JP2024540692A (ja) | 2021-11-09 | 2022-11-09 | リン（ｖ）およびカンプトテシン部分を含むコンジュゲート |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230158154A1 (enExample) |
| EP (1) | EP4429709A1 (enExample) |
| JP (1) | JP2024540692A (enExample) |
| KR (1) | KR20240100415A (enExample) |
| CN (1) | CN118302198A (enExample) |
| AU (1) | AU2022386680A1 (enExample) |
| CA (1) | CA3237379A1 (enExample) |
| CL (1) | CL2024001373A1 (enExample) |
| CO (1) | CO2024005880A2 (enExample) |
| DE (1) | DE22817180T1 (enExample) |
| ES (1) | ES3001145T1 (enExample) |
| IL (1) | IL312677A (enExample) |
| MX (1) | MX2024005545A (enExample) |
| PE (1) | PE20242114A1 (enExample) |
| TW (1) | TW202339803A (enExample) |
| WO (1) | WO2023083919A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| AU2024332412A1 (en) | 2023-09-01 | 2026-03-12 | Tubulis Gmbh | Methods of preparing phosphonamidate compounds |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| US12521446B2 (en) | 2024-02-27 | 2026-01-13 | Bristol-Myers Squibb Company | Anti-CEACAM5 antibody drug conjugates |
| WO2025262641A1 (en) | 2024-06-19 | 2025-12-26 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
| WO2026016639A1 (zh) * | 2024-07-19 | 2026-01-22 | 昆山新蕴达生物科技有限公司 | 一种靶向adam-9的抗体-药物偶联物及其制备方法和用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990006952A1 (fr) | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| JP3008226B2 (ja) | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
| JP2763020B2 (ja) | 1995-04-27 | 1998-06-11 | 日本電気株式会社 | 半導体パッケージ及び半導体装置 |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| EP0964702B1 (en) | 1996-08-02 | 2006-10-04 | Ortho-McNeil Pharmaceutical, Inc. | Polypeptides having a single covalently bound n-terminal water-soluble polymer |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| SV2007002227A (es) | 2004-09-10 | 2007-03-20 | Wyeth Corp | Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637 |
| US7687496B2 (en) * | 2007-10-16 | 2010-03-30 | Bionumerik Pharmaceuticals, Inc. | C7-substituted camptothecin analogs |
| NZ610239A (en) | 2008-04-30 | 2014-11-28 | Immunogen Inc | Cross-linkers and their uses |
| ES3029483T3 (en) * | 2008-09-17 | 2025-06-24 | Endocyte Inc | Folate receptor binding conjugates of antifolates |
| NZ758049A (en) | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| JP7137474B2 (ja) | 2016-03-15 | 2022-09-14 | メルサナ セラピューティクス，インコーポレイティド | ＮａＰｉ２ｂ標的化抗体－薬物コンジュゲート及びその使用方法 |
| AU2017320913B2 (en) | 2016-09-01 | 2024-08-15 | Forschungsverbund Berlin E.V. | Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates |
| KR102772724B1 (ko) | 2018-03-07 | 2025-02-24 | 포슝스베르분드 베를린 에.베. | 알켄 또는 알킨-포스포노티올레이트 및 -포스포네이트로의 화학선택적 티올-접합 |
| BR112020020466A2 (pt) * | 2018-04-06 | 2021-01-12 | Seattle Genetics, Inc. | Conjugados de peptídeo de camptotecina |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| EP3976112A1 (en) | 2019-06-03 | 2022-04-06 | Synaffix B.V. | Acetal-based cleavable linkers |
| IL289094A (en) * | 2019-06-17 | 2022-02-01 | Tagworks Pharmaceuticals B V | Tetrazines for increasing the speed and yield of the "click release" reaction |
| DK3983363T3 (da) * | 2019-06-17 | 2024-06-24 | Tagworks Pharmaceuticals B V | Forbindelser til hurtig og effektiv klikfrigivelse |
-
2022
- 2022-11-09 ES ES22817180T patent/ES3001145T1/es active Pending
- 2022-11-09 PE PE2024001006A patent/PE20242114A1/es unknown
- 2022-11-09 KR KR1020247019075A patent/KR20240100415A/ko active Pending
- 2022-11-09 TW TW111142866A patent/TW202339803A/zh unknown
- 2022-11-09 MX MX2024005545A patent/MX2024005545A/es unknown
- 2022-11-09 IL IL312677A patent/IL312677A/en unknown
- 2022-11-09 US US18/054,063 patent/US20230158154A1/en active Pending
- 2022-11-09 DE DE22817180.7T patent/DE22817180T1/de active Pending
- 2022-11-09 CA CA3237379A patent/CA3237379A1/en active Pending
- 2022-11-09 CN CN202280074840.5A patent/CN118302198A/zh active Pending
- 2022-11-09 AU AU2022386680A patent/AU2022386680A1/en active Pending
- 2022-11-09 JP JP2024549577A patent/JP2024540692A/ja active Pending
- 2022-11-09 WO PCT/EP2022/081371 patent/WO2023083919A1/en not_active Ceased
- 2022-11-09 EP EP22817180.7A patent/EP4429709A1/en active Pending
-
2024
- 2024-05-06 CO CONC2024/0005880A patent/CO2024005880A2/es unknown
- 2024-05-06 CL CL2024001373A patent/CL2024001373A1/es unknown
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