JP2024540358A - 工学操作ロイシン脱炭酸酵素 - Google Patents

工学操作ロイシン脱炭酸酵素 Download PDF

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Publication number
JP2024540358A
JP2024540358A JP2024526835A JP2024526835A JP2024540358A JP 2024540358 A JP2024540358 A JP 2024540358A JP 2024526835 A JP2024526835 A JP 2024526835A JP 2024526835 A JP2024526835 A JP 2024526835A JP 2024540358 A JP2024540358 A JP 2024540358A
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JP
Japan
Prior art keywords
amino acid
seq
engineered
leucine decarboxylase
acid sequence
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Pending
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JP2024526835A
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English (en)
Japanese (ja)
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JP2024540358A5 (enExample
Inventor
ベンジャミン アスファハ ジョナサン
ダス サブハモイ
ローン デュ フェイ
ジェーン ステファン
ディー．クルーゼ ニッキ
リウ ジョイス
マクルスキー ケリン
メームード ロアサ
ピー．シルバーマン アダム
ジーン バリュー クリステン
Original Assignee
シンティス バイオ，インコーポレイティド
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Publication of JP2024540358A publication Critical patent/JP2024540358A/ja
Publication of JP2024540358A5 publication Critical patent/JP2024540358A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01014—Valine decarboxylase (4.1.1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2024526835A 2021-11-01 2022-11-01 工学操作ロイシン脱炭酸酵素 Pending JP2024540358A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163274395P 2021-11-01 2021-11-01
US63/274,395 2021-11-01
PCT/US2022/079089 WO2023077169A2 (en) 2021-11-01 2022-11-01 Engineered leucine decarboxylases

Publications (2)

Publication Number Publication Date
JP2024540358A true JP2024540358A (ja) 2024-10-31
JP2024540358A5 JP2024540358A5 (enExample) 2025-11-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024526835A Pending JP2024540358A (ja) 2021-11-01 2022-11-01 工学操作ロイシン脱炭酸酵素

Country Status (7)

Country Link
US (1) US12502421B2 (enExample)
EP (1) EP4426827A4 (enExample)
JP (1) JP2024540358A (enExample)
CN (1) CN118475692A (enExample)
AU (1) AU2022377148A1 (enExample)
CA (1) CA3236731A1 (enExample)
WO (1) WO2023077169A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103711A4 (en) 2020-02-04 2024-02-28 Codexis, Inc. Engineered leucine decarboxylases
JP2024540358A (ja) 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
EP4763227A1 (en) * 2024-12-19 2026-06-24 Perseo Pharma AG Functionalized branched-chain amino acid-degrading enzyme compositions

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Also Published As

Publication number Publication date
AU2022377148A1 (en) 2024-06-13
WO2023077169A3 (en) 2023-07-27
US12502421B2 (en) 2025-12-23
EP4426827A4 (en) 2026-02-11
US20230277635A1 (en) 2023-09-07
CN118475692A (zh) 2024-08-09
CA3236731A1 (en) 2023-05-04
EP4426827A2 (en) 2024-09-11
WO2023077169A2 (en) 2023-05-04

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