CA3236731A1 - Engineered leucine decarboxylases - Google Patents

Engineered leucine decarboxylases Download PDF

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Publication number
CA3236731A1
CA3236731A1 CA3236731A CA3236731A CA3236731A1 CA 3236731 A1 CA3236731 A1 CA 3236731A1 CA 3236731 A CA3236731 A CA 3236731A CA 3236731 A CA3236731 A CA 3236731A CA 3236731 A1 CA3236731 A1 CA 3236731A1
Authority
CA
Canada
Prior art keywords
amino acid
seq
engineered
leucine decarboxylase
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3236731A
Other languages
English (en)
French (fr)
Inventor
Jonathan Benjamin ASFAHA
Subhamoy Das
Faye Loan Du
Stephan JENNE
Nikki D. Kruse
Joyce Liu
Kerryn Mccluskie
Roasa MEHMOOD
Adam P. Silverman
Kristen Jean Vallieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntis Bio Inc
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of CA3236731A1 publication Critical patent/CA3236731A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01014—Valine decarboxylase (4.1.1.14)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3236731A 2021-11-01 2022-11-01 Engineered leucine decarboxylases Pending CA3236731A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163274395P 2021-11-01 2021-11-01
US63/274,395 2021-11-01
PCT/US2022/079089 WO2023077169A2 (en) 2021-11-01 2022-11-01 Engineered leucine decarboxylases

Publications (1)

Publication Number Publication Date
CA3236731A1 true CA3236731A1 (en) 2023-05-04

Family

ID=86158596

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3236731A Pending CA3236731A1 (en) 2021-11-01 2022-11-01 Engineered leucine decarboxylases

Country Status (7)

Country Link
US (1) US12502421B2 (enExample)
EP (1) EP4426827A4 (enExample)
JP (1) JP2024540358A (enExample)
CN (1) CN118475692A (enExample)
AU (1) AU2022377148A1 (enExample)
CA (1) CA3236731A1 (enExample)
WO (1) WO2023077169A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103711A4 (en) 2020-02-04 2024-02-28 Codexis, Inc. Engineered leucine decarboxylases
JP2024540358A (ja) 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
EP4763227A1 (en) * 2024-12-19 2026-06-24 Perseo Pharma AG Functionalized branched-chain amino acid-degrading enzyme compositions

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Also Published As

Publication number Publication date
AU2022377148A1 (en) 2024-06-13
WO2023077169A3 (en) 2023-07-27
US12502421B2 (en) 2025-12-23
EP4426827A4 (en) 2026-02-11
US20230277635A1 (en) 2023-09-07
JP2024540358A (ja) 2024-10-31
CN118475692A (zh) 2024-08-09
EP4426827A2 (en) 2024-09-11
WO2023077169A2 (en) 2023-05-04

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