|
US5457038A
(en)
|
1988-11-10 |
1995-10-10 |
Genetics Institute, Inc. |
Natural killer stimulatory factor
|
|
US5573764A
(en)
|
1994-01-21 |
1996-11-12 |
Genetics Institute, Inc. |
Use of interleukin-12 to prevent graft versus host disease
|
|
US5891680A
(en)
|
1995-02-08 |
1999-04-06 |
Whitehead Institute For Biomedical Research |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
ES2590912T3
(es)
|
1997-12-08 |
2016-11-24 |
Merck Patent Gmbh |
Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario
|
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
|
MXPA02001417A
(es)
|
1999-08-09 |
2002-08-12 |
Lexigen Pharm Corp |
Complejos multiples de citosina-anticuerpo.
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
WO2002085923A2
(en)
|
2001-04-19 |
2002-10-31 |
The Scripps Research Institute |
In vivo incorporation of unnatural amino acids
|
|
US7282204B2
(en)
|
2003-03-10 |
2007-10-16 |
Schering Corporation |
Uses of IL-23 agonists and antagonists; related reagents
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US8802643B1
(en)
|
2003-05-30 |
2014-08-12 |
University Of South Florida |
Method for the treatment of malignancies
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8546543B2
(en)
|
2004-11-12 |
2013-10-01 |
Xencor, Inc. |
Fc variants that extend antibody half-life
|
|
DK2439273T3
(da)
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
CN103145842A
(zh)
|
2005-06-30 |
2013-06-12 |
Abbvie公司 |
Il-12/p40结合蛋白
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
PL1966238T3
(pl)
|
2005-12-30 |
2012-09-28 |
Merck Patent Gmbh |
Warianty interleukiny-12p40 o polepszonej stabilności
|
|
JP6157046B2
(ja)
|
2008-01-07 |
2017-07-05 |
アムジェン インコーポレイテッド |
静電的ステアリング(electrostaticsteering)効果を用いた抗体Fcヘテロ二量体分子を作製するための方法
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
JP2012515556A
(ja)
|
2009-01-23 |
2012-07-12 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
低下したエフェクタ機能を有する安定化Fcポリペプチドおよび使用方法
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
US9527926B2
(en)
|
2010-05-14 |
2016-12-27 |
Rinat Neuroscience Corp. |
Heterodimeric proteins and methods for producing and purifying them
|
|
ES2758994T3
(es)
|
2010-11-05 |
2020-05-07 |
Zymeworks Inc |
Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc
|
|
US9714291B2
(en)
|
2012-10-05 |
2017-07-25 |
Kyowa Hakko Kirin Co., Ltd |
Heterodimer protein composition
|
|
EP2970486B1
(en)
|
2013-03-15 |
2018-05-16 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
MX387323B
(es)
|
2014-02-19 |
2025-03-18 |
Merck Patent Gmbh |
Il-12 dirigida al cáncer en combinación con il-7 para usarse en el tratamiento de cáncer.
|
|
EP3197911A4
(en)
|
2014-09-22 |
2018-06-20 |
Intrexon Corporation |
Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
|
|
GB201505305D0
(en)
|
2015-03-27 |
2015-05-13 |
Immatics Biotechnologies Gmbh |
Novel Peptides and combination of peptides for use in immunotherapy against various tumors
|
|
US11087249B2
(en)
|
2016-05-24 |
2021-08-10 |
Ciambella Ltd. |
Method and apparatus for triggering execution of a workflow over a network
|
|
US10696722B2
(en)
*
|
2016-08-10 |
2020-06-30 |
Ajou University Industry-Academic Cooperation Foundation |
Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same
|
|
US10232053B2
(en)
|
2016-12-30 |
2019-03-19 |
Trieza Therapeutics, Inc. |
Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
|
|
AU2018219887B2
(en)
|
2017-02-08 |
2024-08-15 |
Dragonfly Therapeutics, LLC |
Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
|
|
SE541511C2
(sv)
|
2017-03-06 |
2019-10-22 |
Slaettberg Fredrik |
Installationsklara vägg- och regelkassetter
|
|
CN110101843A
(zh)
|
2018-02-01 |
2019-08-09 |
北京科诺科服生物科技有限公司 |
一种抗肿瘤蛋白质及其应用
|
|
BR112020015994A2
(pt)
|
2018-02-08 |
2020-12-15 |
Dragonfly Therapeutics, Inc. |
Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
|
|
CN110396133B
(zh)
|
2018-04-25 |
2021-07-23 |
免疫靶向有限公司 |
一种以白介素12为活性成分的融合蛋白型药物前体
|
|
WO2019222296A1
(en)
|
2018-05-14 |
2019-11-21 |
Werewolf Therapeutics, Inc. |
Activatable interleukin 12 polypeptides and methods of use thereof
|
|
AU2019355971B2
(en)
|
2018-10-03 |
2025-05-08 |
Xencor, Inc. |
IL-12 heterodimeric Fc-fusion proteins
|
|
SG11202104136YA
(en)
|
2018-10-23 |
2021-05-28 |
Dragonfly Therapeutics Inc |
Heterodimeric fc-fused proteins
|
|
BR112022001320A2
(pt)
|
2019-07-25 |
2022-04-12 |
Univ Chicago |
Composições e métodos compreendendo agentes terapêuticos ativados por protease
|
|
US11851466B2
(en)
|
2019-10-03 |
2023-12-26 |
Xencor, Inc. |
Targeted IL-12 heterodimeric Fc-fusion proteins
|
|
CA3166009A1
(en)
|
2020-01-14 |
2021-07-22 |
Synthekine, Inc. |
Il2 muteins
|
|
WO2021146436A2
(en)
|
2020-01-14 |
2021-07-22 |
Synthekine, Inc. |
Biased il2 muteins methods and compositions
|
|
CN115916261A
(zh)
|
2020-04-17 |
2023-04-04 |
小利兰·斯坦福大学董事会 |
工程化il-12和il-23多肽及其用途
|
|
MX2022013112A
(es)
|
2020-04-22 |
2023-01-16 |
Dragonfly Therapeutics Inc |
Fórmulacion, regimen de dosificación y proceso de manufactura de proteínas heterodiméricas fusionadas con fc.
|
|
EP4334337A2
(en)
|
2021-05-05 |
2024-03-13 |
Ankyra Therapeutics, Inc. |
Fusion polypeptides
|
|
CA3234552A1
(en)
|
2021-10-20 |
2023-04-27 |
Synthekine, Inc. |
Heterodimeric fc cytokines and uses thereof
|
|
WO2023070038A2
(en)
*
|
2021-10-20 |
2023-04-27 |
Synthekine, Inc. |
Human il-12p40 variants and uses thereof
|