JP2024534162A5 - - Google Patents
Info
- Publication number
- JP2024534162A5 JP2024534162A5 JP2024513053A JP2024513053A JP2024534162A5 JP 2024534162 A5 JP2024534162 A5 JP 2024534162A5 JP 2024513053 A JP2024513053 A JP 2024513053A JP 2024513053 A JP2024513053 A JP 2024513053A JP 2024534162 A5 JP2024534162 A5 JP 2024534162A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- trifluoromethyl
- methylpiperidine
- phenol
- triazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163237049P | 2021-08-25 | 2021-08-25 | |
| US63/237,049 | 2021-08-25 | ||
| US202263311463P | 2022-02-18 | 2022-02-18 | |
| US63/311,463 | 2022-02-18 | ||
| PCT/US2022/075421 WO2023028534A1 (en) | 2021-08-25 | 2022-08-24 | Inhibitors of nlrp3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024534162A JP2024534162A (ja) | 2024-09-18 |
| JP2024534162A5 true JP2024534162A5 (cg-RX-API-DMAC10.html) | 2025-09-02 |
Family
ID=83438923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024513053A Pending JP2024534162A (ja) | 2021-08-25 | 2022-08-24 | Ｎｌｒｐ３の阻害剤 |
Country Status (14)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| WO2022230912A1 (ja) | 2021-04-28 | 2022-11-03 | アステラス製薬株式会社 | 置換トリアジン化合物 |
| CA3226995A1 (en) * | 2021-07-21 | 2023-01-26 | Nico Therapeutics, Inc. | Annulated pyridazine compound |
| CN118302417A (zh) * | 2021-08-25 | 2024-07-05 | Ptc医疗公司 | Nlrp3抑制剂 |
| WO2023051761A1 (zh) * | 2021-09-30 | 2023-04-06 | 成都奥睿药业有限公司 | 一类取代杂芳酞嗪衍生物的药学用途及其制备方法 |
| CN118234730A (zh) * | 2021-11-17 | 2024-06-21 | 豪夫迈·罗氏有限公司 | 杂环nlrp3抑制剂 |
| EP4493556A4 (en) * | 2022-03-15 | 2026-03-18 | Zomagen Biosciences Ltd | NLRP3 MODULATORS |
| KR20250005125A (ko) * | 2022-03-25 | 2025-01-09 | 벤투스 테라퓨틱스 유에스 인코포레이티드 | NLRP3 유도체로서 유용한 피리도-[3,4-d]피리다진 아민 유도체 |
| EP4499646A4 (en) * | 2022-03-31 | 2026-03-18 | Hangzhou Highlightll Pharmaceutical Co Ltd | NLRP3 Inflammasome Inhibitors |
| WO2024006559A1 (en) * | 2022-07-01 | 2024-01-04 | Neumora Therapeutics, Inc. | Modulators of nlrp3 inflammasome and related products and methods |
| JP2025524640A (ja) * | 2022-07-14 | 2025-07-30 | エーシー・イミューン・エス・アー | Ｎｌｒｐ３インフラマソーム経路の調節剤としてのピロロトリアジン及びイミダゾトリアジン誘導体 |
| CN119907797A (zh) * | 2022-09-23 | 2025-04-29 | 默沙东有限责任公司 | 用作nod样受体蛋白3抑制剂的酞嗪衍生物 |
| JP7863148B2 (ja) * | 2022-09-23 | 2026-05-20 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体 |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| US20260167637A1 (en) * | 2022-11-04 | 2026-06-18 | Transthera Sciences (Nanjing), Inc. | Nlrp3 inflammasome inhibitor and use thereof |
| CN120379995A (zh) * | 2022-12-27 | 2025-07-25 | 正大天晴药业集团股份有限公司 | 一种哒嗪稠芳环化合物及其用途 |
| CN120418236A (zh) * | 2022-12-28 | 2025-08-01 | 长春金赛药业有限责任公司 | 哒嗪类nlrp3抑制剂化合物、药物组合物及其制备方法和应用 |
| JP2026504422A (ja) * | 2023-01-31 | 2026-02-05 | ヤンセン ファーマシューティカ エヌ．ベー． | ＮＬＲＰ３阻害剤としてのピロロ［１，２－ｄ］［１，２，４］トリアジン及びピラゾロ［１，５－ｄ］［１，２，４］トリアジン |
| EP4658644A1 (en) * | 2023-01-31 | 2025-12-10 | Janssen Pharmaceutica NV | 2-(pyridazin-3-yl)-5-(trifluoromethyl)phenols as nlrp3 inhibitors |
| TW202502746A (zh) * | 2023-03-14 | 2025-01-16 | 法商賽諾菲公司 | 嗒<img file="IMG-2/Others/113108930-A0202-11-0001-171.TIF" he="64" img-content="character" img-format="tif" inline="no" orientation="portrait" wi="54"/>化合物、其製備及其治療用途 |
| TW202448892A (zh) * | 2023-04-17 | 2024-12-16 | 大陸商上海拓界生物醫藥科技有限公司 | 稠合噠嗪類衍生物及其用途 |
| AU2024280075A1 (en) | 2023-06-02 | 2025-12-11 | Merck Sharp & Dohme Llc | 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3 |
| WO2025006681A2 (en) * | 2023-06-27 | 2025-01-02 | Viva Star Biosciences (Us) Inc. | Substituted pyridazine compounds as inhibitors of nlrp3 activity and therapeutic uses thereof |
| WO2025133307A1 (en) * | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Heterocyclic modulators of the nlrp3 inflammasome pathway |
| CN122580319A (zh) * | 2024-01-05 | 2026-08-14 | 北京普祺医药科技股份有限公司 | 杂环化合物及其药物组合物 |
| TW202545527A (zh) | 2024-01-16 | 2025-12-01 | 英商諾得瑟拉公司 | Ｎｌｒｐ３及ｇｌｐ－１ａ組合療法 |
| CN122555707A (zh) * | 2024-01-17 | 2026-08-11 | Ac免疫有限公司 | 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物 |
| CN122555708A (zh) * | 2024-01-17 | 2026-08-11 | Ac免疫有限公司 | 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物 |
| WO2026002229A1 (zh) * | 2024-06-28 | 2026-01-02 | 长春金赛药业有限责任公司 | 一种nlrp3抑制剂化合物及其制备方法和应用 |
| WO2026047040A1 (en) * | 2024-08-28 | 2026-03-05 | Sanofi | Pyridazine compounds, their preparation, and their therapeutic uses |
| WO2026057747A1 (en) | 2024-09-11 | 2026-03-19 | Ac Immune Sa | Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds |
| WO2026132518A1 (en) | 2024-12-20 | 2026-06-25 | Ac Immune Sa | Heterocyclic compounds modulating the nlrp3 inflammasome pathway |
| WO2026133229A1 (en) * | 2024-12-20 | 2026-06-25 | Novartis Ag | Nlrp3 inflammasome inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08208654A (ja) * | 1994-11-24 | 1996-08-13 | Wakamoto Pharmaceut Co Ltd | キマーゼ活性を阻害し、かつ一酸化窒素生成を抑制する新規トリアジン誘導体 |
| GB9919957D0 (en) * | 1999-08-23 | 1999-10-27 | Merck Sharp & Dohme | Therapeutic agents |
| GB0008696D0 (en) * | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
| EP1837329A4 (en) | 2005-01-14 | 2009-08-05 | Dainippon Sumitomo Pharma Co | NEW HETEROARYL DERIVATIVE |
| AU2008300019A1 (en) * | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
| KR102507847B1 (ko) * | 2016-10-28 | 2023-03-08 | 서울대학교병원 | 페닐 프탈라진 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
| BR112020009757A2 (pt) * | 2017-12-15 | 2020-11-03 | Revolution Medicines, Inc. | compostos policíclicos como inibidores alostéricos de shp2 |
| CA3139821A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| AR119731A1 (es) * | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
| WO2020239076A1 (zh) | 2019-05-29 | 2020-12-03 | 南京明德新药研发有限公司 | 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用 |
| TW202231281A (zh) * | 2020-12-25 | 2022-08-16 | 大陸商上海拓界生物醫藥科技有限公司 | 一類含噠嗪的化合物及其醫藥用途 |
| US11319319B1 (en) * | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| JP2024529839A (ja) * | 2021-06-29 | 2024-08-14 | ズーマゲン バイオサイエンシーズ エルティーディー | Ｎｌｒｐ３モジュレーター |
| PL4363406T3 (pl) * | 2021-07-02 | 2026-01-05 | Astrazeneca Ab | Inhibitory inflamasomu nlrp3 |
| CA3226995A1 (en) | 2021-07-21 | 2023-01-26 | Nico Therapeutics, Inc. | Annulated pyridazine compound |
-
2022
- 2022-08-24 IL IL310992A patent/IL310992A/en unknown
- 2022-08-24 AU AU2022334474A patent/AU2022334474A1/en active Pending
- 2022-08-24 JP JP2024513053A patent/JP2024534162A/ja active Pending
- 2022-08-24 PE PE2024000299A patent/PE20241727A1/es unknown
- 2022-08-24 EP EP22777142.5A patent/EP4392414A1/en active Pending
- 2022-08-24 US US18/256,099 patent/US20240262806A1/en active Pending
- 2022-08-24 MX MX2024002342A patent/MX2024002342A/es unknown
- 2022-08-24 CA CA3229539A patent/CA3229539A1/en active Pending
- 2022-08-24 WO PCT/US2022/075421 patent/WO2023028534A1/en not_active Ceased
- 2022-08-24 KR KR1020247005965A patent/KR20240069714A/ko active Pending
- 2022-08-24 CR CR20240093A patent/CR20240093A/es unknown
-
2024
- 2024-02-22 CO CONC2024/0001922A patent/CO2024001922A2/es unknown
- 2024-02-22 CL CL2024000552A patent/CL2024000552A1/es unknown
- 2024-02-23 EC ECSENADI202414832A patent/ECSP24014832A/es unknown
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