JP2024530774A - 環状グアノシン一リン酸アナログの改善された生成方法 - Google Patents

環状グアノシン一リン酸アナログの改善された生成方法 Download PDF

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JP2024530774A
JP2024530774A JP2024513779A JP2024513779A JP2024530774A JP 2024530774 A JP2024530774 A JP 2024530774A JP 2024513779 A JP2024513779 A JP 2024513779A JP 2024513779 A JP2024513779 A JP 2024513779A JP 2024530774 A JP2024530774 A JP 2024530774A
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JP
Japan
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cgmp
guanosine
general formula
analogue
analog
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JP2024513779A
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Japanese (ja)
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JP2024530774A5 (https=
Inventor
マーティン ボルマーク，
フランク ディーター シュヴェーデ，
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ミレカ メディシンズ ゲーエムベーハー
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Publication of JP2024530774A5 publication Critical patent/JP2024530774A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024513779A 2021-09-06 2022-09-06 環状グアノシン一リン酸アナログの改善された生成方法 Pending JP2024530774A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21195043 2021-09-06
EP21195043.1 2021-09-06
PCT/EP2022/074740 WO2023031481A1 (en) 2021-09-06 2022-09-06 Improved methods for production of cyclic guanosine-monophosphate analogues

Publications (2)

Publication Number Publication Date
JP2024530774A true JP2024530774A (ja) 2024-08-23
JP2024530774A5 JP2024530774A5 (https=) 2025-09-16

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ID=77640578

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JP2024513779A Pending JP2024530774A (ja) 2021-09-06 2022-09-06 環状グアノシン一リン酸アナログの改善された生成方法

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US (1) US20240352056A1 (https=)
EP (1) EP4399215A1 (https=)
JP (1) JP2024530774A (https=)
CN (1) CN117999269A (https=)
WO (1) WO2023031481A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025160090A1 (en) * 2024-01-22 2025-07-31 Wave Life Sciences Ltd. Technol. ogies useful for oligonucleotide preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1336442A (en) * 1969-10-10 1973-11-07 Anvar Preparation of adenosine-3,5-monophosphoric acid derivatives
US5625056A (en) 1992-05-26 1997-04-29 Biolog Life Science Institute Derivatives of cyclic guanosine-3',5'-monophosphorothioate
ITMI20022306A1 (it) * 2002-10-30 2004-04-30 Fructamine Spa Guanosine modificate ad attivita' aromatizzante.
GB0413726D0 (en) 2004-06-18 2004-07-21 Lauras As Compounds
CA2819041A1 (en) * 2010-12-22 2012-06-28 Alios Biopharma, Inc. Cyclic nucleotide analogs
WO2012130829A1 (en) 2011-03-29 2012-10-04 Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb Gmbh New boranophosphate analogues of cyclic nucleotides
CA3069586A1 (en) 2016-07-11 2018-01-18 Mireca Medicines Gmbh New equatorially modified polymer linked multimers of guanosine-3', 5'-cyclic monophosphates

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Publication number Publication date
WO2023031481A1 (en) 2023-03-09
CN117999269A (zh) 2024-05-07
US20240352056A1 (en) 2024-10-24
EP4399215A1 (en) 2024-07-17

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