CN117999269A - 用于生产环状鸟苷-单磷酸酯类似物的改进方法 - Google Patents

用于生产环状鸟苷-单磷酸酯类似物的改进方法 Download PDF

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Publication number
CN117999269A
CN117999269A CN202280060253.0A CN202280060253A CN117999269A CN 117999269 A CN117999269 A CN 117999269A CN 202280060253 A CN202280060253 A CN 202280060253A CN 117999269 A CN117999269 A CN 117999269A
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CN
China
Prior art keywords
guanosine
cgmp
analogue
general formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280060253.0A
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English (en)
Chinese (zh)
Inventor
M·博尔马克
F·D·施韦德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mireka Pharmaceutical Co ltd
Original Assignee
Mireka Pharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mireka Pharmaceutical Co ltd filed Critical Mireka Pharmaceutical Co ltd
Publication of CN117999269A publication Critical patent/CN117999269A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202280060253.0A 2021-09-06 2022-09-06 用于生产环状鸟苷-单磷酸酯类似物的改进方法 Pending CN117999269A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21195043 2021-09-06
EP21195043.1 2021-09-06
PCT/EP2022/074740 WO2023031481A1 (en) 2021-09-06 2022-09-06 Improved methods for production of cyclic guanosine-monophosphate analogues

Publications (1)

Publication Number Publication Date
CN117999269A true CN117999269A (zh) 2024-05-07

Family

ID=77640578

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280060253.0A Pending CN117999269A (zh) 2021-09-06 2022-09-06 用于生产环状鸟苷-单磷酸酯类似物的改进方法

Country Status (5)

Country Link
US (1) US20240352056A1 (https=)
EP (1) EP4399215A1 (https=)
JP (1) JP2024530774A (https=)
CN (1) CN117999269A (https=)
WO (1) WO2023031481A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025160090A1 (en) * 2024-01-22 2025-07-31 Wave Life Sciences Ltd. Technol. ogies useful for oligonucleotide preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1336442A (en) * 1969-10-10 1973-11-07 Anvar Preparation of adenosine-3,5-monophosphoric acid derivatives
US5625056A (en) 1992-05-26 1997-04-29 Biolog Life Science Institute Derivatives of cyclic guanosine-3',5'-monophosphorothioate
ITMI20022306A1 (it) * 2002-10-30 2004-04-30 Fructamine Spa Guanosine modificate ad attivita' aromatizzante.
GB0413726D0 (en) 2004-06-18 2004-07-21 Lauras As Compounds
CA2819041A1 (en) * 2010-12-22 2012-06-28 Alios Biopharma, Inc. Cyclic nucleotide analogs
WO2012130829A1 (en) 2011-03-29 2012-10-04 Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb Gmbh New boranophosphate analogues of cyclic nucleotides
CA3069586A1 (en) 2016-07-11 2018-01-18 Mireca Medicines Gmbh New equatorially modified polymer linked multimers of guanosine-3', 5'-cyclic monophosphates

Also Published As

Publication number Publication date
WO2023031481A1 (en) 2023-03-09
JP2024530774A (ja) 2024-08-23
US20240352056A1 (en) 2024-10-24
EP4399215A1 (en) 2024-07-17

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