JP2024528682A - 薬物組成物及び用途 - Google Patents

薬物組成物及び用途 Download PDF

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Publication number
JP2024528682A
JP2024528682A JP2024503607A JP2024503607A JP2024528682A JP 2024528682 A JP2024528682 A JP 2024528682A JP 2024503607 A JP2024503607 A JP 2024503607A JP 2024503607 A JP2024503607 A JP 2024503607A JP 2024528682 A JP2024528682 A JP 2024528682A
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JP
Japan
Prior art keywords
seq
antibody
sequence
amino acid
variable region
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Pending
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JP2024503607A
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Japanese (ja)
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JP2024528682A5 (enExample
Inventor
ワン，ジョンミン
リ，バイヨン
シア，ユ
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Akeso Pharmaceuticals Inc
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Akeso Biopharma Inc
Akeso Pharmaceuticals Inc
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Publication of JP2024528682A publication Critical patent/JP2024528682A/ja
Publication of JP2024528682A5 publication Critical patent/JP2024528682A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
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JP2024503607A 2021-07-23 2022-07-22 薬物組成物及び用途 Pending JP2024528682A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202110842497 2021-07-23
CN202110842497.1 2021-07-23
PCT/CN2022/107522 WO2023001303A1 (zh) 2021-07-23 2022-07-22 药物组合物及用途

Publications (2)

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JP2024528682A true JP2024528682A (ja) 2024-07-30
JP2024528682A5 JP2024528682A5 (enExample) 2026-06-08

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JP2024503607A Pending JP2024528682A (ja) 2021-07-23 2022-07-22 薬物組成物及び用途

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US (1) US20240352153A1 (enExample)
EP (1) EP4375300A4 (enExample)
JP (1) JP2024528682A (enExample)
KR (1) KR20240038043A (enExample)
CN (1) CN116059341A (enExample)
AU (1) AU2022314097A1 (enExample)
CA (1) CA3226242A1 (enExample)
IL (1) IL310217A (enExample)
MX (1) MX2024001067A (enExample)
WO (1) WO2023001303A1 (enExample)
ZA (1) ZA202400787B (enExample)

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KR20230098221A (ko) * 2020-10-26 2023-07-03 아케소 바이오파마, 인크. 항-tigit 항체, 약학 조성물 및 이의 용도
IL322840A (en) * 2023-02-20 2025-10-01 Akeso Biopharma Co Ltd Fusion protein comprising a TGF-βRII extracellular region fragment, its pharmaceutical composition and use
WO2025016012A1 (en) * 2023-07-14 2025-01-23 Genor Biopharma Co., Ltd. Anti-PD-1/CTLA-4/TIGIT TRISPECIFIC ANTIBODIES AND USE THEREOF
WO2025201450A1 (zh) * 2024-03-27 2025-10-02 康方汇科(上海)生物有限公司 药物组合及用途
WO2025232896A1 (zh) * 2024-05-10 2025-11-13 康方汇科(上海)生物有限公司 药物组合及用途

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CN112794909B (zh) * 2021-02-04 2022-06-14 广州爱思迈生物医药科技有限公司 一种抗tigit单克隆抗体及其应用
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CN114181310B (zh) * 2022-02-14 2022-07-05 中山康方生物医药有限公司 抗tigit抗体、其药物组合物及用途

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AU2022314097A1 (en) 2024-03-07
CN116059341A (zh) 2023-05-05
WO2023001303A1 (zh) 2023-01-26
MX2024001067A (es) 2024-02-27
EP4375300A4 (en) 2025-08-27
US20240352153A1 (en) 2024-10-24
CA3226242A1 (en) 2023-01-26

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