JP2024527997A5 - - Google Patents
Info
- Publication number
- JP2024527997A5 JP2024527997A5 JP2024505066A JP2024505066A JP2024527997A5 JP 2024527997 A5 JP2024527997 A5 JP 2024527997A5 JP 2024505066 A JP2024505066 A JP 2024505066A JP 2024505066 A JP2024505066 A JP 2024505066A JP 2024527997 A5 JP2024527997 A5 JP 2024527997A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- gene
- receptor
- exogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163226559P | 2021-07-28 | 2021-07-28 | |
| US63/226,559 | 2021-07-28 | ||
| PCT/US2022/074251 WO2023010073A1 (en) | 2021-07-28 | 2022-07-28 | Compositions and methods for improving t cell persistence and function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024527997A JP2024527997A (ja) | 2024-07-26 |
| JP2024527997A5 true JP2024527997A5 (https=) | 2025-08-04 |
Family
ID=85087331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024505066A Pending JP2024527997A (ja) | 2021-07-28 | 2022-07-28 | Ｔ細胞持続性及び機能を改善するための組成物及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240327826A1 (https=) |
| EP (1) | EP4376858A4 (https=) |
| JP (1) | JP2024527997A (https=) |
| CN (1) | CN117813102A (https=) |
| WO (1) | WO2023010073A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4665363A1 (en) * | 2023-02-17 | 2025-12-24 | Dana-Farber Cancer Institute, Inc. | Compositions and methods of preventing t cell exhaustion |
| WO2025185585A1 (zh) * | 2024-03-05 | 2025-09-12 | 上海沙砾生物科技有限公司 | 一种鉴定靶标的方法及其应用 |
| CN118345080B (zh) * | 2024-06-17 | 2024-09-24 | 江苏柯菲平医药股份有限公司 | 一种抗耗竭t细胞及其制备方法、应用 |
| CN119120385B (zh) * | 2024-11-14 | 2025-03-14 | 四川大学华西医院 | 一种具有长效抑瘤效果的嵌合抗原受体t细胞及其制备方法和用途 |
| CN121294362A (zh) * | 2025-12-11 | 2026-01-09 | 良渚实验室 | Tada2b基因在促进红系终末分化中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021501156A (ja) * | 2017-10-27 | 2021-01-14 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｔ細胞疲弊を予防および逆転するためのエピジェネティック標的および転写標的の同定 |
| EP3723774A4 (en) * | 2017-12-15 | 2021-09-08 | The Board of Trustees of the Leland Stanford Junior University | COMPOSITIONS AND METHODS OF INHIBITION OF T-CELL EXHAUSTATION |
| US11447769B2 (en) * | 2018-03-27 | 2022-09-20 | The Trustees Of The University Of Pennsylvania | Modified immune cells having enhanced function and methods for screening for same |
| CN110904045A (zh) * | 2018-09-17 | 2020-03-24 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| WO2020198340A1 (en) * | 2019-03-26 | 2020-10-01 | The Trustees Of The University Of Pennsylvania | Dnmt3a knockout car t cells for adoptive immunotherapy |
| US20220226380A1 (en) * | 2019-04-24 | 2022-07-21 | St. Jude Children's Research Hospital, Inc. | Gene knock-outs to improve t cell function |
-
2022
- 2022-07-28 EP EP22850516.0A patent/EP4376858A4/en active Pending
- 2022-07-28 JP JP2024505066A patent/JP2024527997A/ja active Pending
- 2022-07-28 CN CN202280052739.XA patent/CN117813102A/zh active Pending
- 2022-07-28 WO PCT/US2022/074251 patent/WO2023010073A1/en not_active Ceased
- 2022-07-28 US US18/580,472 patent/US20240327826A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024527997A5 (https=) | ||
| US12241053B2 (en) | Modulation of novel immune checkpoint targets | |
| US12447213B2 (en) | Modulation of novel immune checkpoint targets | |
| EP1615662B1 (de) | Transfektion von blutzellen mit mrna zur immunstimulation und gentherapie | |
| WO2018204764A1 (en) | Identification and targeted modulation of gene signaling networks | |
| AU2019384547B2 (en) | Compositions and methods for increasing fetal hemoglobin and treating sickle cell disease | |
| CN109689089A (zh) | 治疗癌症的方法和组合物 | |
| JP2021522188A (ja) | 内因性遺伝子活性化を用いる多重腫瘍ワクチン接種のための組成物および方法 | |
| WO2019080537A1 (zh) | 包含溶瘤病毒和car-nk细胞的治疗剂及应用、药盒、治疗肿瘤和/或癌症的方法 | |
| JP2023138660A5 (https=) | ||
| JP2022541293A (ja) | がん細胞療法用のｐ２１発現単球 | |
| CN117716026A (zh) | 具有氧化应激抗性的间充质干细胞、其制备方法及用途 | |
| CN111575297A (zh) | 诱导型Fms相关酪氨酸激酶3配体修饰的细胞及其用途 | |
| JP2024544587A (ja) | 異常メチル化の超高感度検出のための断片コンセンサス法 | |
| CN116327949A (zh) | Lhpp基因在肝癌免疫治疗中的应用及肝癌免疫治疗药物 | |
| US20220392638A1 (en) | Precision enrichment of pathology specimens | |
| CN119998457A (zh) | 基于金属纳米颗粒-核酸缀合物的基因载体 | |
| CN117379389A (zh) | 血小板-溶瘤病毒复合物、其制备方法及其应用 | |
| CN120555509B (zh) | 氨磷汀在提高基因组定点插入效率中的应用 | |
| US20250268938A1 (en) | Small molecule-regulated cell signaling expression system | |
| CN121160628A (zh) | 一种制备通用型t细胞的新方法 | |
| CN120285192A (zh) | Ube2f、Cul5或Rnf7在预防和/或治疗感染中的用途 | |
| CN119700985A (zh) | Bcor和Zc3h12a在预防和治疗慢性感染中的用途 | |
| EP4581170A2 (en) | Methods for evaluating clonal tumor mutational burden | |
| CN121801840A (zh) | 具有增强抗肿瘤活性的sting基因敲除的til及其制备方法和应用 |