JP2024527997A - Ｔ細胞持続性及び機能を改善するための組成物及び方法 - Google Patents

Ｔ細胞持続性及び機能を改善するための組成物及び方法 Download PDF

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JP2024527997A
JP2024527997A JP2024505066A JP2024505066A JP2024527997A JP 2024527997 A JP2024527997 A JP 2024527997A JP 2024505066 A JP2024505066 A JP 2024505066A JP 2024505066 A JP2024505066 A JP 2024505066A JP 2024527997 A JP2024527997 A JP 2024527997A
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cells
cell
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arid1a
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JPWO2023010073A5 (https=
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サトパシー，アンスマン
ベルク，ジュリア
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • A—HUMAN NECESSITIES
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N9/14—Hydrolases (3)
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/50—Colon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector

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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP2024505066A 2021-07-28 2022-07-28 Ｔ細胞持続性及び機能を改善するための組成物及び方法 Pending JP2024527997A (ja)

Applications Claiming Priority (3)

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US202163226559P 2021-07-28 2021-07-28
US63/226,559 2021-07-28
PCT/US2022/074251 WO2023010073A1 (en) 2021-07-28 2022-07-28 Compositions and methods for improving t cell persistence and function

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JP2024527997A true JP2024527997A (ja) 2024-07-26
JPWO2023010073A5 JPWO2023010073A5 (https=) 2025-08-04
JP2024527997A5 JP2024527997A5 (https=) 2025-08-04

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US (1) US20240327826A1 (https=)
EP (1) EP4376858A4 (https=)
JP (1) JP2024527997A (https=)
CN (1) CN117813102A (https=)
WO (1) WO2023010073A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2024173916A1 (en) * 2023-02-17 2024-08-22 Dana-Farber Cancer Institute, Inc. Compositions and methods of preventing t cell exhaustion
WO2025185585A1 (zh) * 2024-03-05 2025-09-12 上海沙砾生物科技有限公司 一种鉴定靶标的方法及其应用
CN118345080B (zh) * 2024-06-17 2024-09-24 江苏柯菲平医药股份有限公司 一种抗耗竭t细胞及其制备方法、应用
CN119120385B (zh) * 2024-11-14 2025-03-14 四川大学华西医院 一种具有长效抑瘤效果的嵌合抗原受体t细胞及其制备方法和用途
CN121294362A (zh) * 2025-12-11 2026-01-09 良渚实验室 Tada2b基因在促进红系终末分化中的应用

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WO2019084495A1 (en) * 2017-10-27 2019-05-02 The Trustees Of The University Of Pennsylvania IDENTIFICATION OF EPIGENETIC AND TRANSCRIPTIONAL TARGETS TO PREVENT AND REVERSE T-LYMPHOCYTE EXHAUST
US11400117B2 (en) * 2017-12-15 2022-08-02 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for inhibiting T cell exhaustion
US11447769B2 (en) * 2018-03-27 2022-09-20 The Trustees Of The University Of Pennsylvania Modified immune cells having enhanced function and methods for screening for same
CN110904045A (zh) * 2018-09-17 2020-03-24 中国科学院动物研究所 经修饰的t细胞、其制备方法及用途
US20220354889A1 (en) * 2019-03-26 2022-11-10 The Trustees Of The University Of Pennsylvania Dnmt3a knockout car t cells for adoptive immunotherapy
WO2020219682A2 (en) * 2019-04-24 2020-10-29 St. Jude Children's Research Hospital, Inc. Gene knock-outs to improve t cell function

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US20240327826A1 (en) 2024-10-03
WO2023010073A1 (en) 2023-02-02
EP4376858A1 (en) 2024-06-05
EP4376858A4 (en) 2025-10-01
CN117813102A (zh) 2024-04-02

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