JP2024526880A - 脳標的化組成物及びその使用方法 - Google Patents

脳標的化組成物及びその使用方法 Download PDF

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Publication number
JP2024526880A
JP2024526880A JP2024503534A JP2024503534A JP2024526880A JP 2024526880 A JP2024526880 A JP 2024526880A JP 2024503534 A JP2024503534 A JP 2024503534A JP 2024503534 A JP2024503534 A JP 2024503534A JP 2024526880 A JP2024526880 A JP 2024526880A
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JP
Japan
Prior art keywords
dose
administered
antigen
binding fragment
antibody
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Pending
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JP2024503534A
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English (en)
Japanese (ja)
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JP2024526880A5 (https=
Inventor
マイケル ジョン ドルトン，
アンジェリカ リネア クアルティーノ，
ケイシー ミシェル シンク，
ジェフリー アレン カーシュナー，
アーロン デーヴィッド チェスターマン，
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Genentech Inc
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2024526880A publication Critical patent/JP2024526880A/ja
Publication of JP2024526880A5 publication Critical patent/JP2024526880A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024503534A 2021-07-22 2022-07-21 脳標的化組成物及びその使用方法 Pending JP2024526880A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163224848P 2021-07-22 2021-07-22
US63/224,848 2021-07-22
US202163227895P 2021-07-30 2021-07-30
US63/227,895 2021-07-30
PCT/US2022/074007 WO2023004386A1 (en) 2021-07-22 2022-07-21 Brain targeting compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2024526880A true JP2024526880A (ja) 2024-07-19
JP2024526880A5 JP2024526880A5 (https=) 2025-07-29

Family

ID=82899175

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024503534A Pending JP2024526880A (ja) 2021-07-22 2022-07-21 脳標的化組成物及びその使用方法

Country Status (5)

Country Link
US (1) US20240254210A1 (https=)
EP (1) EP4373576A1 (https=)
JP (1) JP2024526880A (https=)
TW (1) TW202311283A (https=)
WO (1) WO2023004386A1 (https=)

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Also Published As

Publication number Publication date
TW202311283A (zh) 2023-03-16
US20240254210A1 (en) 2024-08-01
EP4373576A1 (en) 2024-05-29
WO2023004386A9 (en) 2024-01-25
WO2023004386A1 (en) 2023-01-26

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