JP2024526730A5 - - Google Patents
Info
- Publication number
- JP2024526730A5 JP2024526730A5 JP2024501665A JP2024501665A JP2024526730A5 JP 2024526730 A5 JP2024526730 A5 JP 2024526730A5 JP 2024501665 A JP2024501665 A JP 2024501665A JP 2024501665 A JP2024501665 A JP 2024501665A JP 2024526730 A5 JP2024526730 A5 JP 2024526730A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- alkyl
- nucleotide
- solid support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163222269P | 2021-07-15 | 2021-07-15 | |
| US63/222,269 | 2021-07-15 | ||
| US202163236022P | 2021-08-23 | 2021-08-23 | |
| US63/236,022 | 2021-08-23 | ||
| US202163246479P | 2021-09-21 | 2021-09-21 | |
| US63/246,479 | 2021-09-21 | ||
| PCT/US2022/037260 WO2023288045A2 (en) | 2021-07-15 | 2022-07-15 | Simple chemical approaches to introduce 2,6-diaminopurine and 2-aminoadenine conjugates into oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024526730A JP2024526730A (ja) | 2024-07-19 |
| JP2024526730A5 true JP2024526730A5 (https=) | 2025-07-14 |
Family
ID=84920550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024501665A Pending JP2024526730A (ja) | 2021-07-15 | 2022-07-15 | ２，６－ジアミノプリン及び２－アミノアデニンのコンジュゲートをオリゴヌクレオチドに導入するための簡便な化学的アプローチ |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20250025564A1 (https=) |
| EP (1) | EP4370136A4 (https=) |
| JP (1) | JP2024526730A (https=) |
| WO (1) | WO2023288045A2 (https=) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681941A (en) * | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
| US6175004B1 (en) * | 1998-09-01 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Process for the synthesis of oligonucleotides incorporating 2-aminoadenosine |
| JP3681338B2 (ja) * | 2001-03-14 | 2005-08-10 | 独立行政法人科学技術振興機構 | シクロプロピル基導入塩基を含有したｄｎａ |
| US6921812B1 (en) * | 2001-07-03 | 2005-07-26 | Isis Pharmaceuticals, Inc. | Methods of modulating pharmacokinetics of oligonucleotides |
| WO2008100447A2 (en) * | 2007-02-09 | 2008-08-21 | Gilead Sciences, Inc. | Nucleoside analogs for antiviral treatment |
| WO2009099942A2 (en) * | 2008-01-31 | 2009-08-13 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides and uses thereof |
| EP2270021A1 (en) * | 2009-06-18 | 2011-01-05 | Centre National de la Recherche Scientifique | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
| WO2019123339A1 (en) * | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
-
2022
- 2022-07-15 EP EP22842917.1A patent/EP4370136A4/en active Pending
- 2022-07-15 JP JP2024501665A patent/JP2024526730A/ja active Pending
- 2022-07-15 US US18/577,888 patent/US20250025564A1/en active Pending
- 2022-07-15 WO PCT/US2022/037260 patent/WO2023288045A2/en not_active Ceased
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