JP2024525727A - 抗体由来の結合ドメインに融合した操作されたｔ細胞受容体 - Google Patents

抗体由来の結合ドメインに融合した操作されたｔ細胞受容体 Download PDF

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JP2024525727A
JP2024525727A JP2024501757A JP2024501757A JP2024525727A JP 2024525727 A JP2024525727 A JP 2024525727A JP 2024501757 A JP2024501757 A JP 2024501757A JP 2024501757 A JP2024501757 A JP 2024501757A JP 2024525727 A JP2024525727 A JP 2024525727A
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antigen
polypeptide
tcr
cell
seq
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JP2024525727A5 (enExample
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ジョーダン ジャージョル，
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２セブンティ バイオ インコーポレイテッド
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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JP2024501757A 2021-07-14 2022-07-14 抗体由来の結合ドメインに融合した操作されたｔ細胞受容体 Pending JP2024525727A (ja)

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US202163221819P 2021-07-14 2021-07-14
US63/221,819 2021-07-14
PCT/US2022/073725 WO2023288267A1 (en) 2021-07-14 2022-07-14 Engineered t cell receptors fused to binding domains from antibodies

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JP2024525727A true JP2024525727A (ja) 2024-07-12
JP2024525727A5 JP2024525727A5 (enExample) 2025-07-23

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US (1) US20240342215A1 (enExample)
EP (1) EP4370541A1 (enExample)
JP (1) JP2024525727A (enExample)
KR (1) KR20240034234A (enExample)
CN (1) CN117980326A (enExample)
AU (1) AU2022310862A1 (enExample)
CA (1) CA3225252A1 (enExample)
IL (1) IL309957A (enExample)
WO (1) WO2023288267A1 (enExample)

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CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
WO2020227475A1 (en) 2019-05-08 2020-11-12 Bluebird Bio, Inc. Cll-1 targeted immunotherapies
WO2021195503A1 (en) * 2020-03-27 2021-09-30 2Seventy Bio, Inc. T cell receptors
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
JP1785905S (ja) * 2024-03-14 2024-11-29 コネクタ
WO2026078266A1 (en) * 2024-10-11 2026-04-16 Fundacion Para La Investigacion Medica Aplicada Bcma specific single domain antibodies (sdab), cars and other products derived therefrom, and their uses in therapy and diagnosis
WO2026082164A1 (en) * 2024-10-18 2026-04-23 Scg Cell Therapy Pte. Ltd. A modified dual-targeting t cell receptor complex and its pharmaceutical application thereof

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WO2020147708A1 (en) * 2019-01-14 2020-07-23 Nanjing Legend Biotech Co., Ltd. Chimeric receptor polypeptides and uses thereof
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