JP2024523891A - Ａａｖ産生方法 - Google Patents
Ａａｖ産生方法 Download PDFInfo
- Publication number
- JP2024523891A JP2024523891A JP2023577659A JP2023577659A JP2024523891A JP 2024523891 A JP2024523891 A JP 2024523891A JP 2023577659 A JP2023577659 A JP 2023577659A JP 2023577659 A JP2023577659 A JP 2023577659A JP 2024523891 A JP2024523891 A JP 2024523891A
- Authority
- JP
- Japan
- Prior art keywords
- hours
- aav
- cells
- glutamine
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163211877P | 2021-06-17 | 2021-06-17 | |
| US63/211,877 | 2021-06-17 | ||
| PCT/IB2022/000347 WO2022263930A2 (en) | 2021-06-17 | 2022-06-17 | Aav manufacturing methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024523891A true JP2024523891A (ja) | 2024-07-02 |
| JP2024523891A5 JP2024523891A5 (https=) | 2025-06-17 |
Family
ID=82850181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023577659A Pending JP2024523891A (ja) | 2021-06-17 | 2022-06-17 | Ａａｖ産生方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240279682A1 (https=) |
| EP (1) | EP4355887A2 (https=) |
| JP (1) | JP2024523891A (https=) |
| KR (1) | KR20240054958A (https=) |
| CN (1) | CN117730154A (https=) |
| AU (1) | AU2022292164A1 (https=) |
| BR (1) | BR112023026523A2 (https=) |
| CA (1) | CA3222723A1 (https=) |
| IL (1) | IL309351A (https=) |
| MX (1) | MX2023015291A (https=) |
| WO (1) | WO2022263930A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4713466A1 (en) * | 2023-05-18 | 2026-03-25 | Solid Biosciences Inc. | Single plasmid system for aav production |
| WO2025063664A1 (ko) * | 2023-09-18 | 2025-03-27 | 삼성바이오에피스 주식회사 | 재조합 aav 생산을 위한 단일 벡터 시스템 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017112948A1 (en) * | 2015-12-24 | 2017-06-29 | University Of Florida Research Foundation, Inc. | Improved aav production using suspension adapted cells |
| MA44546B1 (fr) | 2016-06-15 | 2021-03-31 | Univ California | Virus adéno-associés variants et procédés d'utilisation |
| KR20210093862A (ko) * | 2018-09-21 | 2021-07-28 | 나이트스타엑스 리미티드 | 유전자 요법 벡터를 제작하기 위한 조성물 및 방법 |
| CN109666697B (zh) * | 2019-01-30 | 2020-03-10 | 广州派真生物技术有限公司 | 一种提高腺相关病毒产量的生产工艺 |
| JP2023503850A (ja) * | 2019-11-14 | 2023-02-01 | バイオマリン ファーマシューティカル インコーポレイテッド | 肝臓特異的遺伝子療法ベクターによる遺伝性血管浮腫の治療 |
-
2022
- 2022-06-17 KR KR1020247000732A patent/KR20240054958A/ko active Pending
- 2022-06-17 US US18/571,478 patent/US20240279682A1/en active Pending
- 2022-06-17 MX MX2023015291A patent/MX2023015291A/es unknown
- 2022-06-17 WO PCT/IB2022/000347 patent/WO2022263930A2/en not_active Ceased
- 2022-06-17 IL IL309351A patent/IL309351A/en unknown
- 2022-06-17 AU AU2022292164A patent/AU2022292164A1/en active Pending
- 2022-06-17 BR BR112023026523A patent/BR112023026523A2/pt not_active Application Discontinuation
- 2022-06-17 EP EP22753761.0A patent/EP4355887A2/en active Pending
- 2022-06-17 CA CA3222723A patent/CA3222723A1/en active Pending
- 2022-06-17 CN CN202280050835.0A patent/CN117730154A/zh active Pending
- 2022-06-17 JP JP2023577659A patent/JP2024523891A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN117730154A (zh) | 2024-03-19 |
| CA3222723A1 (en) | 2022-12-22 |
| KR20240054958A (ko) | 2024-04-26 |
| AU2022292164A1 (en) | 2024-02-01 |
| WO2022263930A3 (en) | 2023-01-26 |
| MX2023015291A (es) | 2024-03-25 |
| BR112023026523A2 (pt) | 2024-03-05 |
| WO2022263930A2 (en) | 2022-12-22 |
| EP4355887A2 (en) | 2024-04-24 |
| IL309351A (en) | 2024-02-01 |
| US20240279682A1 (en) | 2024-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250609 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250609 |
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| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20260413 |
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| A131 | Notification of reasons for refusal |
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