JP2024520643A - ナトリウムチャネルの調節因子としてのヒドロキシ及び(ハロ)アルコキシ置換テトラヒドロフラン - Google Patents
ナトリウムチャネルの調節因子としてのヒドロキシ及び(ハロ)アルコキシ置換テトラヒドロフラン Download PDFInfo
- Publication number
- JP2024520643A JP2024520643A JP2023574370A JP2023574370A JP2024520643A JP 2024520643 A JP2024520643 A JP 2024520643A JP 2023574370 A JP2023574370 A JP 2023574370A JP 2023574370 A JP2023574370 A JP 2023574370A JP 2024520643 A JP2024520643 A JP 2024520643A
- Authority
- JP
- Japan
- Prior art keywords
- pain
- pharma
- compound
- acceptable salt
- ceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163197141P | 2021-06-04 | 2021-06-04 | |
| US63/197,141 | 2021-06-04 | ||
| PCT/US2022/072758 WO2022256842A1 (en) | 2021-06-04 | 2022-06-03 | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024520643A true JP2024520643A (ja) | 2024-05-24 |
| JP2024520643A5 JP2024520643A5 (enExample) | 2025-06-11 |
Family
ID=82482756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023574370A Pending JP2024520643A (ja) | 2021-06-04 | 2022-06-03 | ナトリウムチャネルの調節因子としてのヒドロキシ及び(ハロ)アルコキシ置換テトラヒドロフラン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240294512A1 (enExample) |
| EP (1) | EP4347033A1 (enExample) |
| JP (1) | JP2024520643A (enExample) |
| CN (1) | CN117858875A (enExample) |
| AU (1) | AU2022286511A1 (enExample) |
| CA (1) | CA3221960A1 (enExample) |
| WO (1) | WO2022256842A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| KR20250052383A (ko) * | 2022-08-24 | 2025-04-18 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 헤테로시클릭계 화합물, 이의 제조 방법 및 이의 의학적 응용 |
| CN119731169A (zh) * | 2022-08-28 | 2025-03-28 | 上海汇伦医药股份有限公司 | 一种钠通道调节剂及其应用 |
| EP4647430A4 (en) * | 2023-01-06 | 2026-03-11 | Haisco Pharmaceutical Group Co Ltd | Tetrahydrothiophene derivative and its use in medicine |
| CN116082363B (zh) * | 2023-02-16 | 2025-11-21 | 西安交通大学 | 一种雷帕霉素40-位羟基的烷基化合成方法 |
| WO2024188367A1 (zh) * | 2023-03-10 | 2024-09-19 | 西藏海思科制药有限公司 | 一种四氢呋喃衍生物及其在医药上的应用 |
| WO2024217557A1 (zh) * | 2023-04-19 | 2024-10-24 | 武汉人福创新药物研发中心有限公司 | 取代的四氢呋喃作为Nav1.8抑制剂 |
| CN119371405A (zh) | 2023-07-26 | 2025-01-28 | 上海闻耐医药科技有限公司 | 多取代吡咯烷类衍生物、其制备方法及用途 |
| WO2025067219A1 (zh) * | 2023-09-25 | 2025-04-03 | 江苏恒瑞医药股份有限公司 | 杂环类化合物、其制备方法及其在医药上的应用 |
| WO2025090465A1 (en) * | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090480A1 (en) * | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| AR134204A1 (es) * | 2023-11-01 | 2025-12-10 | Insilico Medicine Ip Ltd | Nuevos compuestos como moduladores de los canales de sodio y usos de los mismos |
| WO2025092922A1 (en) * | 2023-11-02 | 2025-05-08 | Iongen Therapeutics Co., Ltd. | Compounds, compositions and methods thereof |
| CN120208958A (zh) * | 2023-12-26 | 2025-06-27 | 南京清普生物科技有限公司 | 一种新型钠通道调节剂 |
| WO2025162194A1 (zh) * | 2024-01-31 | 2025-08-07 | 上海汇伦医药股份有限公司 | 钠通道调节剂新化合物及其应用 |
| WO2025168043A1 (zh) * | 2024-02-08 | 2025-08-14 | 上海枢境生物科技有限公司 | 并环类衍生物、制备方法及其用途 |
| CN120040429B (zh) * | 2024-02-23 | 2026-03-31 | 山东盛迪医药有限公司 | 一种取代四氢呋喃衍生物的结晶形式及其用途 |
| CN120040430A (zh) * | 2024-02-23 | 2025-05-27 | 山东盛迪医药有限公司 | 一种取代四氢呋喃衍生物的可药用盐、其结晶形式及用途 |
| WO2025176204A1 (zh) * | 2024-02-23 | 2025-08-28 | 江苏恒瑞医药股份有限公司 | 一种吡啶-n-氧化物衍生物的结晶形式、盐及其用途 |
| CN120774914A (zh) * | 2024-04-03 | 2025-10-14 | 武汉人福创新药物研发中心有限公司 | 作为Nav1.8抑制剂的四氢呋喃吡啶酮类化合物 |
| WO2025223429A1 (zh) * | 2024-04-22 | 2025-10-30 | 晶新医药研发(上海)有限公司 | 一种五元杂环类化合物、药物组合物及其应用 |
| WO2025223433A1 (zh) * | 2024-04-22 | 2025-10-30 | 晶新医药研发(上海)有限公司 | 一种五元杂环类化合物、药物组合物及其应用 |
| WO2025223430A1 (zh) * | 2024-04-22 | 2025-10-30 | 晶新医药研发(上海)有限公司 | 一种五元杂环类化合物、药物组合物及其应用 |
| CN118388466A (zh) * | 2024-04-23 | 2024-07-26 | 安润医药科技(苏州)有限公司 | 作钠通道调节剂的酰胺衍生物及其用途 |
| WO2025252109A1 (zh) * | 2024-06-04 | 2025-12-11 | 成都苑东生物制药股份有限公司 | 一种取代四氢呋喃类衍生物、其制备方法及用途 |
| US20260001877A1 (en) * | 2024-06-28 | 2026-01-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CN119143737B (zh) * | 2024-11-18 | 2025-07-18 | 嘉兴安帝康生物科技有限公司 | 四氢呋喃甲酰胺类钠通道调节剂及其在医药上的应用 |
| CN119285621B (zh) * | 2024-12-13 | 2025-07-18 | 嘉兴安帝康生物科技有限公司 | 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509881A (ja) * | 2000-09-19 | 2004-04-02 | メルク シャープ エンド ドーム リミテッド | テトラヒドロフラン誘導体および治療薬としてのその使用 |
| WO2020092667A1 (en) * | 2018-11-02 | 2020-05-07 | Merck Sharp & Dohme Corp. | 2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors |
| JP2020526561A (ja) * | 2017-07-11 | 2020-08-31 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | ナトリウムチャネルのモジュレーターとしてのカルボキサミド |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| AU2001275881B2 (en) | 2000-07-10 | 2006-04-06 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| ES2234451T1 (es) | 2001-11-14 | 2005-07-01 | Teva Pharmaceutical Industries Ltd. | Formas cristalinas y amorfas de losartan potasio y procedimiento para su preparacion. |
| AU2005266090A1 (en) | 2004-07-23 | 2006-02-02 | Pfizer Inc. | Pyridine derivatives |
| WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| CA2684105C (en) | 2007-05-03 | 2011-09-06 | Pfizer Limited | Pyridine derivatives |
| MX2011006904A (es) | 2008-12-26 | 2011-07-20 | Dainippon Sumitomo Pharma Co | Compuesto heterociclico biciclico novedoso. |
| CA2760946C (en) | 2009-05-07 | 2019-06-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for studying, imaging, and treating pain |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| WO2011026240A1 (en) | 2009-09-04 | 2011-03-10 | Zalicus Pharmaceuticals Ltd. | Oxopiperazine derivatives for the treatment of pain and epilepsy |
| US8598164B2 (en) | 2010-05-06 | 2013-12-03 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| KR101923367B1 (ko) | 2011-02-02 | 2018-12-04 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드 |
| MX2013009393A (es) | 2011-02-18 | 2013-08-29 | Vertex Pharma | Piperidinamidas cromano-espirociclicas como moduladores de canales de iones. |
| CA2828456C (en) | 2011-03-03 | 2021-05-04 | Zalicus Pharmaceuticals Ltd. | N-benzl-amino-carboxamide inhibitors of the sodium channel |
| CN103517910B (zh) | 2011-03-14 | 2016-12-14 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吗啉-螺环哌啶酰胺 |
| CA2850925C (en) | 2011-10-26 | 2017-01-10 | Pfizer Limited | (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators |
| US9012443B2 (en) | 2011-12-07 | 2015-04-21 | Amgen Inc. | Bicyclic aryl and heteroaryl sodium channel inhibitors |
| NZ627259A (en) | 2012-01-16 | 2016-12-23 | Vertex Pharma | Pyran-spirocyclic piperidine amides as modulators of ion channels |
| JP6002785B2 (ja) | 2012-02-03 | 2016-10-05 | ファイザー・インク | ナトリウムチャネルモジュレーターとしてのベンゾイミダゾールおよびイミダゾピリジン誘導体 |
| WO2013131018A1 (en) | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
| WO2013134518A1 (en) | 2012-03-09 | 2013-09-12 | Amgen Inc. | Sulfamide sodium channel inhibitors |
| RS56015B1 (sr) | 2013-01-31 | 2017-09-29 | Vertex Pharma | Piridon amidi kao modulatori natrijumovih kanala |
| RU2683788C2 (ru) | 2013-01-31 | 2019-04-02 | Вертекс Фармасьютикалз Инкорпорейтед | Амиды хинолина и хиназолина, полезные в качестве модуляторов натриевых каналов |
| CA2898653C (en) | 2013-01-31 | 2021-09-28 | Vertex Pharmaceuticals Incorporated | Amides as modulators of sodium channels |
| US9776995B2 (en) | 2013-06-12 | 2017-10-03 | Amgen Inc. | Bicyclic sulfonamide compounds as sodium channel inhibitors |
| UA119147C2 (uk) | 2013-07-19 | 2019-05-10 | Вертекс Фармасьютікалз Інкорпорейтед | Сульфонаміди як модулятори натрієвих каналів |
| CA2931550C (en) | 2013-12-13 | 2023-09-26 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
| WO2015157559A2 (en) | 2014-04-09 | 2015-10-15 | Siteone Therapeutics, Inc. | 10',11'-modified saxitoxins for the treatment of pain |
| EA032928B1 (ru) | 2015-03-02 | 2019-08-30 | Эмджен Инк. | Бициклические кетосульфонамидные соединения |
| ES2895155T3 (es) | 2015-09-30 | 2022-02-17 | Siteone Therapeutics Inc | Saxitoxinas modificadas en 11,13 para el tratamiento del dolor |
| CN110831945B (zh) | 2017-03-29 | 2023-08-08 | 赛特温治疗公司 | 用于治疗疼痛的11,13-修饰的石房蛤毒素类化合物 |
| US11279706B2 (en) | 2017-03-29 | 2022-03-22 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
| EP3625214B1 (en) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| CA3105657A1 (en) | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting nav1.8 |
| AU2019302534B2 (en) | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| EP3860714B1 (en) | 2018-10-03 | 2023-09-06 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
| US12344595B2 (en) | 2018-11-02 | 2025-07-01 | Merck Sharp & Dohme Llc | 2-amino-n-phenyl-nicotinamides as NAV1.8 inhibitors |
| EP3891157A4 (en) | 2018-12-05 | 2022-08-31 | Merck Sharp & Dohme Corp. | 4-AMINO- OR 4-ALKOXY-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATE SODIUM CHANNELS |
| US20220073471A1 (en) | 2019-01-04 | 2022-03-10 | Jiangsu Hengrui Medicine Co., Ltd. | 6-oxo-1,6-dihydropyridazine derivative, preparation method therefor and medical use thereof |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| TW202043200A (zh) | 2019-01-25 | 2020-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 2-側氧基-1,2-二氫吡啶類衍生物、其製備方法及其在醫藥上的應用 |
| MX2021015605A (es) | 2019-06-27 | 2022-02-16 | Glaxosmithkline Ip Dev Ltd | Compuestos 2,3-dihidroquinazolin como inhibidores nav1.8. |
| CN112300069A (zh) | 2019-07-31 | 2021-02-02 | 明慧医药(上海)有限公司 | 一种选择性钠通道调节剂及其制备和应用 |
| CN112300051A (zh) | 2019-07-31 | 2021-02-02 | 明慧医药(上海)有限公司 | 一种选择性钠通道调节剂及其制备和应用 |
| CN112390745B (zh) | 2019-08-19 | 2022-10-21 | 江苏恒瑞医药股份有限公司 | 吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用 |
| WO2021032074A1 (zh) | 2019-08-19 | 2021-02-25 | 江苏恒瑞医药股份有限公司 | 苯甲酰胺稠芳环类衍生物、其制备方法及其在医药上的应用 |
| CN112441969A (zh) | 2019-08-30 | 2021-03-05 | 明慧医药(上海)有限公司 | 一种选择性钠通道调节剂及其制备和应用 |
| BR112022004495A8 (pt) | 2019-09-12 | 2023-04-18 | Jiangxi Jemincare Group Co Ltd | Compostos oxinitreto de piridina, composição farmacêutica compreendendo os mesmos e usos dos mesmos |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| CN111217776A (zh) | 2020-01-19 | 2020-06-02 | 中国人民解放军军事科学院军事医学研究院 | 含苯并杂环结构的酰胺衍生物、组合物和应用 |
| JP7739051B2 (ja) | 2020-06-10 | 2025-09-16 | アムジエン・インコーポレーテツド | シクロブチルジヒドロキノリンスルホンアミド化合物 |
| JP2021195367A (ja) | 2020-06-10 | 2021-12-27 | アムジエン・インコーポレーテツド | シクロプロピルジヒドロキノリンスルホンアミド化合物 |
| CA3183948A1 (en) | 2020-06-10 | 2021-12-16 | Amgen Inc. | Heteroalkyl dihydroquinoline sulfonamide compounds |
| US12516046B2 (en) | 2020-06-17 | 2026-01-06 | Merck Sharp & Dohme Llc | 2-oxo-oxazolidine-5-carboxamides as NAV1.8 inhibitors |
| US11802122B2 (en) | 2020-06-17 | 2023-10-31 | Merck Sharp & Dohme Llc | 2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors |
| CN115697327A (zh) | 2020-06-17 | 2023-02-03 | 默沙东有限责任公司 | 作为nav1.8抑制剂的5-氧代-吡咯烷-3-甲酰胺 |
| EP4196482B1 (en) | 2020-08-14 | 2025-10-01 | SiteOne Therapeutics, Inc. | Non-hydrated ketone inhibitors of nav1.7 for the treatment of pain |
| WO2022037647A1 (zh) | 2020-08-19 | 2022-02-24 | 江苏恒瑞医药股份有限公司 | 一种选择性Nav抑制剂的结晶形式及其制备方法 |
| TW202214259A (zh) | 2020-08-19 | 2022-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種選擇性NaV抑制劑的前藥及其晶型 |
| CN111808019B (zh) | 2020-09-08 | 2020-11-27 | 上海济煜医药科技有限公司 | 一种并环化合物及其应用 |
| CN112225695B (zh) | 2020-12-15 | 2021-03-02 | 上海济煜医药科技有限公司 | 一种氮氧化合物及其制备方法和用途 |
| CN112457294B (zh) | 2021-01-27 | 2021-06-04 | 上海济煜医药科技有限公司 | 一种作为NaV1.8阻滞剂的化合物及其制备方法和用途 |
-
2022
- 2022-06-03 WO PCT/US2022/072758 patent/WO2022256842A1/en not_active Ceased
- 2022-06-03 EP EP22740730.1A patent/EP4347033A1/en active Pending
- 2022-06-03 AU AU2022286511A patent/AU2022286511A1/en active Pending
- 2022-06-03 CA CA3221960A patent/CA3221960A1/en active Pending
- 2022-06-03 CN CN202280053167.7A patent/CN117858875A/zh active Pending
- 2022-06-03 JP JP2023574370A patent/JP2024520643A/ja active Pending
- 2022-06-03 US US18/566,305 patent/US20240294512A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509881A (ja) * | 2000-09-19 | 2004-04-02 | メルク シャープ エンド ドーム リミテッド | テトラヒドロフラン誘導体および治療薬としてのその使用 |
| JP2020526561A (ja) * | 2017-07-11 | 2020-08-31 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | ナトリウムチャネルのモジュレーターとしてのカルボキサミド |
| WO2020092667A1 (en) * | 2018-11-02 | 2020-05-07 | Merck Sharp & Dohme Corp. | 2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022286511A1 (en) | 2023-11-30 |
| CA3221960A1 (en) | 2022-12-08 |
| WO2022256842A1 (en) | 2022-12-08 |
| US20240294512A1 (en) | 2024-09-05 |
| EP4347033A1 (en) | 2024-04-10 |
| CN117858875A (zh) | 2024-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024520643A (ja) | ナトリウムチャネルの調節因子としてのヒドロキシ及び(ハロ)アルコキシ置換テトラヒドロフラン | |
| JP7664925B2 (ja) | ナトリウムチャネルの調節因子としての置換テトラヒドロフラン | |
| EP4347031B1 (en) | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels | |
| JP7465174B2 (ja) | ナトリウムチャネルの調節剤として有用なピリドンアミドのプロドラッグ | |
| JP2024520646A (ja) | ナトリウムチャネルのモジュレーターとしてのn-(ヒドロキシアルキル(ヘテロ)アリール)テトラヒドロフランカルボキサミド類似体 | |
| JP2024522293A (ja) | ナトリウムチャネルのモジュレーターとしての置換テトラヒドロフラン類似体 | |
| KR102295748B1 (ko) | 나트륨 채널의 조절제로서의 피리돈 아미드 | |
| WO2020146612A1 (en) | Esters and carbamates as modulators of sodium channels | |
| TW202523313A (zh) | 用於治療疼痛之雜芳基化合物 | |
| JP2025513452A (ja) | 疼痛の治療のためのヘテロアリール化合物 | |
| JP2025513454A (ja) | 疼痛の治療のためのヘテロアリール化合物 | |
| US20260001877A1 (en) | Heteroaryl compounds for the treatment of pain | |
| HK40080163A (en) | Substituted tetrahydrofurans as modulators of sodium channels | |
| HK40080163B (en) | Substituted tetrahydrofurans as modulators of sodium channels |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250603 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250603 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20260219 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20260226 |