JP2024519614A - Ｐｒａｍｅ特異的ｔ細胞受容体とキメラ補助刺激受容体との組合せ - Google Patents

Ｐｒａｍｅ特異的ｔ細胞受容体とキメラ補助刺激受容体との組合せ Download PDF

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JP2024519614A
JP2024519614A JP2023568236A JP2023568236A JP2024519614A JP 2024519614 A JP2024519614 A JP 2024519614A JP 2023568236 A JP2023568236 A JP 2023568236A JP 2023568236 A JP2023568236 A JP 2023568236A JP 2024519614 A JP2024519614 A JP 2024519614A
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tcr
cells
seq
cell
amino acid
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JP2024519614A5 (https=
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サイラー，ナジャ
サルヴァーモーサー，メラニー
ソンマーメイヤー，ダニエル
ワイルド，スザンヌ
フェッツァー，イナ
ビュルデック，マヤ
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メディジーン イミュノテラピーズ ゲーエムベーハー
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    • A61K35/14—Blood; Artificial blood
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/36—Immune checkpoint inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/427—PRAME
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70521—CD28, CD152
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
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    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/00—Fusion polypeptide
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    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Biotechnology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Wood Science & Technology (AREA)
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JP2023568236A 2021-05-07 2022-05-06 Ｐｒａｍｅ特異的ｔ細胞受容体とキメラ補助刺激受容体との組合せ Pending JP2024519614A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21172722 2021-05-07
EP21172722.7 2021-05-07
PCT/EP2022/062338 WO2022234116A1 (en) 2021-05-07 2022-05-06 Combination of prame specific t cell receptors and chimeric co-stimulatory receptors

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JP2024519614A true JP2024519614A (ja) 2024-05-20
JP2024519614A5 JP2024519614A5 (https=) 2025-05-14

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JP2023568236A Pending JP2024519614A (ja) 2021-05-07 2022-05-06 Ｐｒａｍｅ特異的ｔ細胞受容体とキメラ補助刺激受容体との組合せ

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US (1) US20240277762A1 (https=)
EP (1) EP4334331A1 (https=)
JP (1) JP2024519614A (https=)
KR (1) KR20240005865A (https=)
CN (1) CN117279931A (https=)
AU (1) AU2022270947A1 (https=)
CA (1) CA3215758A1 (https=)
WO (1) WO2022234116A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024146951A1 (en) * 2023-01-06 2024-07-11 Immunocore Limited Binding molecules against a prame peptide-hla complex
WO2025219541A1 (en) * 2024-04-19 2025-10-23 Medigene Immunotherapies Gmbh Constant uni-tabs
EP4635976A1 (en) * 2024-04-19 2025-10-22 Medigene Immunotherapies GmbH Constant uni-tabs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US4851341A (en) 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
EP2006376A1 (en) 2007-06-21 2008-12-24 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof
CA2978171A1 (en) * 2015-03-10 2016-09-15 J.H. Frederik Falkenburg T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof
KR102436129B1 (ko) * 2016-06-17 2022-08-26 메디진 이뮤노테라피스 게엠바하 T 세포 수용체 및 이의 용도
AU2017382243A1 (en) * 2016-12-22 2019-05-02 Windmil Therapeutics, Inc. Compositions and methods for modulating the immune system
GB201709866D0 (en) * 2017-06-20 2017-08-02 Immunocore Ltd T cell receptors
US11738047B2 (en) * 2017-12-12 2023-08-29 The Trustees Of The University Of Pennsylvania Genetically modified immune cells targeting NY-ESO-1 and methods of use thereof
EP3731876A4 (en) * 2017-12-28 2022-04-06 Gritstone bio, Inc. ANTIGEN-BINDING PROTEINS TARGETING SHARED ANTIGENS
US20220401484A1 (en) * 2019-11-18 2022-12-22 BioNTech SE Prame TCR Receptors And Uses Thereof

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Publication number Publication date
KR20240005865A (ko) 2024-01-12
CA3215758A1 (en) 2022-11-10
EP4334331A1 (en) 2024-03-13
US20240277762A1 (en) 2024-08-22
WO2022234116A1 (en) 2022-11-10
CN117279931A (zh) 2023-12-22
AU2022270947A1 (en) 2023-11-16

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