JP2024518792A - 置換ヘテロ環化合物 - Google Patents

置換ヘテロ環化合物 Download PDF

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Publication number
JP2024518792A
JP2024518792A JP2023570181A JP2023570181A JP2024518792A JP 2024518792 A JP2024518792 A JP 2024518792A JP 2023570181 A JP2023570181 A JP 2023570181A JP 2023570181 A JP2023570181 A JP 2023570181A JP 2024518792 A JP2024518792 A JP 2024518792A
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JP
Japan
Prior art keywords
pyridin
amino
alkyl
difluoromethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023570181A
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English (en)
Japanese (ja)
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JP2024518792A5 (https=
Inventor
エドワード マーツマン，マイケル
エム モスリン，ライアン
エイチ スパーゲル，スティーブン
イルムガルト ヴォルム，カーリン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2024518792A publication Critical patent/JP2024518792A/ja
Publication of JP2024518792A5 publication Critical patent/JP2024518792A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2023570181A 2021-05-14 2022-05-13 置換ヘテロ環化合物 Pending JP2024518792A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163188498P 2021-05-14 2021-05-14
US63/188,498 2021-05-14
US202263340629P 2022-05-11 2022-05-11
US63/340,629 2022-05-11
PCT/US2022/029112 WO2022241173A1 (en) 2021-05-14 2022-05-13 Substituted heterocyclic compounds

Publications (2)

Publication Number Publication Date
JP2024518792A true JP2024518792A (ja) 2024-05-02
JP2024518792A5 JP2024518792A5 (https=) 2025-05-21

Family

ID=81927880

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023570181A Pending JP2024518792A (ja) 2021-05-14 2022-05-13 置換ヘテロ環化合物

Country Status (5)

Country Link
US (1) US20250066322A1 (https=)
EP (1) EP4337650A1 (https=)
JP (1) JP2024518792A (https=)
KR (1) KR20240008337A (https=)
WO (1) WO2022241173A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024518556A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518555A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518791A (ja) * 2021-05-14 2024-05-02 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12492184B2 (en) 2020-12-22 2025-12-09 InventisBio Co., Ltd. Heteroaryl compounds, preparation methods and uses thereof
CA3208361A1 (en) 2021-02-19 2022-08-25 Anjali Pandey Tyk2 inhibitors and uses thereof
EP4294806A1 (en) 2021-02-19 2023-12-27 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
AU2022222470A1 (en) 2021-02-19 2023-09-21 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
CN118812511A (zh) * 2023-04-21 2024-10-22 浙江文达医药科技有限公司 作为tyk2抑制剂的杂环化合物及合成和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020086616A1 (en) * 2018-10-22 2020-04-30 Fronthera U.S. Pharmaceuticals Llc Tyk2 inhibitors and uses thereof
JP2021504443A (ja) * 2017-11-21 2021-02-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ スルホンピリジンアルキルアミド置換ヘテロアリール化合物
JP2024518555A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518556A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518554A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518791A (ja) * 2021-05-14 2024-05-02 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3495358T (lt) 2012-11-08 2022-05-25 Bristol-Myers Squibb Company Amidais pakeisti heterocikliniai junginiai, naudingi kaip il-12, il-23 ir (arba) ifn alfa atsako moduliatoriai

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021504443A (ja) * 2017-11-21 2021-02-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ スルホンピリジンアルキルアミド置換ヘテロアリール化合物
WO2020086616A1 (en) * 2018-10-22 2020-04-30 Fronthera U.S. Pharmaceuticals Llc Tyk2 inhibitors and uses thereof
JP2024518555A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518556A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518554A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518791A (ja) * 2021-05-14 2024-05-02 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
橘高敦史, 創薬科学・医薬化学, JPN6017043458, 2007, pages 142 - 150, ISSN: 0005839175 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024518556A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518555A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP2024518791A (ja) * 2021-05-14 2024-05-02 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
JP7818623B2 (ja) 2021-05-14 2026-02-20 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物

Also Published As

Publication number Publication date
EP4337650A1 (en) 2024-03-20
US20250066322A1 (en) 2025-02-27
WO2022241173A1 (en) 2022-11-17
KR20240008337A (ko) 2024-01-18

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