JP2024518022A - 充填ベッドシステムおよび方法を使用したエアロゾル化生体材料粒子の捕捉による呼吸器疾患の診断 - Google Patents

充填ベッドシステムおよび方法を使用したエアロゾル化生体材料粒子の捕捉による呼吸器疾患の診断 Download PDF

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JP2024518022A
JP2024518022A JP2023559992A JP2023559992A JP2024518022A JP 2024518022 A JP2024518022 A JP 2024518022A JP 2023559992 A JP2023559992 A JP 2023559992A JP 2023559992 A JP2023559992 A JP 2023559992A JP 2024518022 A JP2024518022 A JP 2024518022A
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sample
packed bed
maldi
beads
particles
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チェン、ダペン
ブライデン、ウェイン、エイ．
マクローリン、マイケル
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ゼテオ テック、 インク．
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    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
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JP2023559992A 2021-03-31 2022-03-31 充填ベッドシステムおよび方法を使用したエアロゾル化生体材料粒子の捕捉による呼吸器疾患の診断 Pending JP2024518022A (ja)

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US202163169130P 2021-03-31 2021-03-31
US63/169,130 2021-03-31
US202163249357P 2021-09-28 2021-09-28
US63/249,357 2021-09-28
US202263325435P 2022-03-30 2022-03-30
US63/325,435 2022-03-30
PCT/US2022/022964 WO2022212796A1 (en) 2021-03-31 2022-03-31 Diagnosis o respiratory diseases by capturing aerosolized biomaterial particles using packed bed systems and methods

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JP2024518022A true JP2024518022A (ja) 2024-04-24
JP2024518022A5 JP2024518022A5 (https=) 2025-04-02

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US (2) US12575811B2 (https=)
EP (1) EP4312749A4 (https=)
JP (1) JP2024518022A (https=)
KR (2) KR20250049444A (https=)
WO (1) WO2022212796A1 (https=)
ZA (1) ZA202309169B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117883121A (zh) 2019-08-26 2024-04-16 泽特奥科技公司 利用呼出气诊断结核病和其他疾病
US12364411B2 (en) 2020-04-03 2025-07-22 Zeteo Tech, Inc. Diagnosis of respiratory diseases using analysis of exhaled breath and aerosols
EP4146066A1 (en) * 2020-08-27 2023-03-15 Palas GmbH Partikel-und Lasermesstechnik Device and method for characterizing particles of exhaled air
EP4312749A4 (en) * 2021-03-31 2025-07-09 Zeteo Tech Inc DIAGNOSIS OF RESPIRATORY DISEASES BY CAPTURE OF AEROSOLIZED BIOMATERIAL PARTICLES USING FIXED BED SYSTEMS AND METHODS
US20220386893A1 (en) * 2021-03-31 2022-12-08 Zeteo Tech Inc. Capturing truncated proteoforms in exhaled breath for diagnosis and treatment of diseases
JP2025528164A (ja) * 2022-08-11 2025-08-26 ゼテオ テック、 インク． 疾患の診断および治療のための呼気中の切断プロテオフォームの捕捉
WO2025240785A1 (en) * 2024-05-16 2025-11-20 3M Innovative Properties Company Sample collection device and system and a method of collecting and analyzing a sample

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001500365A (ja) * 1996-07-05 2001-01-16 ノバルティス アクチエンゲゼルシャフト Ｐ５３とｍｄｍ２の間の相互作用の阻害剤
JP2005257373A (ja) * 2004-03-10 2005-09-22 Yokohama Tlo Co Ltd 呼気採取装置
JP2016539314A (ja) * 2011-12-12 2016-12-15 ノバルティス アーゲー インフルエンザウイルス血球凝集素のためのアッセイ法
US20200147333A1 (en) * 2018-11-09 2020-05-14 Hound Labs, Inc. Breath sample systems for use with ventilators
WO2021041571A1 (en) * 2019-08-26 2021-03-04 Zeteo Tech, Inc. Diagnosis of tuberculosis and other diseases using exhaled breath

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0989863A (ja) 1995-09-25 1997-04-04 Suzuki Motor Corp 呼気分析装置
JPH09126958A (ja) 1995-10-30 1997-05-16 Suzuki Motor Corp 呼気採取装置
JPH10227725A (ja) 1997-02-12 1998-08-25 Suzuki Motor Corp 呼気分析装置
US6267016B1 (en) 1999-03-10 2001-07-31 Mesosystems Technology, Inc. Impact particulate collector using a rotary impeller for collecting particulates and moving a fluid
US6062392A (en) 1998-11-13 2000-05-16 Mesosystems Technology, Inc. Micromachined virtual impactor
US6534769B1 (en) * 1999-12-31 2003-03-18 Ge Medical Systems Information Technologies, Inc. Low cost main stream gas analyzer system
US7118537B2 (en) 2001-04-30 2006-10-10 Respiratory Research, Inc. Method and device for collecting and analyzing exhaled breath
US7364553B2 (en) 2002-12-20 2008-04-29 Amidex, Inc. Breath aerosol management and collection system
US20050085740A1 (en) 2003-04-01 2005-04-21 Davis Cristina E. Non-invasive breath analysis using field asymmetric ion mobility spectrometry
AU2004294342A1 (en) 2003-12-01 2005-06-16 Sierra Medical Technology, Inc. A respiratory monitoring, diagnostic and therapeutic system
US7562657B2 (en) 2004-06-24 2009-07-21 Convergent Engineering, Inc. Method and apparatus for non-invasive prediction of intrinsic positive end-expiratory pressure (PEEPi) in patients receiving ventilator support
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
JP4564406B2 (ja) 2005-05-25 2010-10-20 株式会社日立製作所 呼気捕集フィルタ、呼気収集装置、呼気分析システムおよび呼気分析方法
US7779840B2 (en) 2006-06-21 2010-08-24 General Electric Company Ventilator breath condensate sampler and method of collecting a breath condensate sample
EP2173423B1 (en) * 2007-07-06 2017-12-20 Maquet Critical Care AB Expiratory valve of an anesthetic breathing apparatus having safety backup
US9675773B2 (en) 2007-09-25 2017-06-13 Oridion Medical (1987) Ltd. Airway tube
CA2701352A1 (en) 2007-10-02 2009-04-09 Ann-Charlotte Almstrand Collection and measurement of exhaled particles
EP2060919A1 (en) 2007-11-13 2009-05-20 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO MALDI matrix and MALDI method
US20090156952A1 (en) 2007-12-13 2009-06-18 Hunter C Eric Apparatuses and Methods for Diagnosing and Treating Respiratory Conditions
JP5848608B2 (ja) 2008-12-01 2016-01-27 トリコーンテク コーポレーションＴｒｉｃｏｒｎＴｅｃｈ Ｃｏｒｐｏｒａｔｉｏｎ 喘息、結核及び肺癌の診断及び疾患管理のための呼気分析システム及び方法
EA023922B1 (ru) * 2009-09-09 2016-07-29 Сенса Буэс Аб Обнаружение лекарственного средства в выдыхаемом воздухе
US9417232B2 (en) 2009-10-02 2016-08-16 Bi Mobile Breath, Inc. Sobriety monitoring system
JP5652847B2 (ja) 2009-11-10 2015-01-14 公益財団法人北九州産業学術推進機構 呼気分析の方法
US8424523B2 (en) 2009-12-03 2013-04-23 Covidien Lp Ventilator respiratory gas accumulator with purge valve
EP2591331A4 (en) 2010-07-06 2017-06-07 Deton Corp. System for airborne bacterial sample collection and analysis
US8747325B2 (en) 2010-07-16 2014-06-10 Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo (Fapesp) Non-invasive method for diagnosing the severity of heart failure by extracting and analyzing acetone concentrations in captured exhaled breath
US20120172677A1 (en) 2010-12-30 2012-07-05 Logan Robert J Systems and methods for monitoring and processing biometric data
US8944059B2 (en) 2011-05-11 2015-02-03 Carefusion 207, Inc. Non-invasive ventilation exhaust gas venting
US9022029B2 (en) 2011-05-11 2015-05-05 Carefusion 207, Inc. Carbon-dioxide sampling system for accurately monitoring carbon dioxide in exhaled breath
US11547322B2 (en) 2012-02-08 2023-01-10 Lundin Stefan Device and method for non-invasive analysis of particles during medical ventilation
EP3667317A1 (en) * 2012-03-08 2020-06-17 Sensa Bues AB A portable sampling device and method for detection of biomarkers in exhaled breath
US9164080B2 (en) 2012-06-11 2015-10-20 Ohio State Innovation Foundation System and method for sensing NO
JP2016512431A (ja) 2013-03-12 2016-04-28 デトン コーポレイション 呼吸サンプルの収集および分析のためのシステム
GB201316524D0 (en) 2013-09-17 2013-10-30 Medical Res Council Biomarkers
US10307080B2 (en) 2014-03-07 2019-06-04 Spirosure, Inc. Respiratory monitor
ES2734380T3 (es) 2014-06-27 2019-12-05 Pulse Health Llc Cartucho de análisis y método de uso del mismo
KR20160009740A (ko) 2014-07-16 2016-01-27 연세대학교 산학협력단 말디톱 질량분석기에 이용가능한 시료 플레이트 및 상기 시료 플레이트의 제조방법, 그리고 상기 시료 플레이트를 이용한 질량분석 방법
JP6770056B2 (ja) 2015-07-20 2020-10-14 フィッシャー アンド ペイケル ヘルスケア リミテッド 呼気ポート
US10463275B2 (en) 2015-08-09 2019-11-05 Elemental Sensor Llc Device for capturing and concentrating volatile organic compounds
EP3334341B1 (en) 2015-08-11 2019-12-25 Koninklijke Philips N.V. Automatic sampling accessory system
US10598668B2 (en) 2015-08-24 2020-03-24 Zeteo Tech, Inc. Coating of aerosol particles using an acoustic coater
EP3143930A1 (en) 2015-09-21 2017-03-22 Université de Liège Method for the diagnosis of airway disease inflammatory subtype
US10226201B2 (en) 2015-10-29 2019-03-12 Invoy Holdings, Llc Flow regulation device for breath analysis and related method
US11116422B2 (en) 2015-12-21 2021-09-14 Koninklijke Philips N.V. Sample cells for respired gas sampling and methods of manufacturing same
KR20180137516A (ko) 2016-04-15 2018-12-27 예일 유니버시티 기체 환경에서 유기 화합물을 모니터링하기 위한 시스템, 기기 및 방법
US10502665B2 (en) 2016-04-18 2019-12-10 University Of Maryland, College Park Aerosol collection system and method
CN109310368A (zh) 2016-04-25 2019-02-05 奥斯通医疗有限公司 用于捕获呼吸样本的系统和设备
US10960002B2 (en) 2016-05-13 2021-03-30 The Brigham And Women's Hospital, Inc. Volatile metabolite profiles for the diagnosis and treatment of Mucorales fungi
AU2017353360B2 (en) 2016-11-07 2023-01-19 AusMed Global Limited Non-invasive photonic sensing for monitoring diabetes
GB201704367D0 (en) 2017-03-20 2017-05-03 Exhalation Tech Ltd A breath condensate analyser
JP6967198B2 (ja) 2017-05-18 2021-11-17 東海光学株式会社 呼気ミスト捕集装置、呼気ミスト分析システム、呼気ミスト捕集方法及び呼気ミスト分析方法
SE541748C2 (en) 2017-07-10 2019-12-10 Pexa Ab System for collecting exhaled particles
GB201801153D0 (en) 2018-01-24 2018-03-07 Owlstone Med Ltd Apparatus and method for obtaining a breath sample
WO2019173501A1 (en) 2018-03-06 2019-09-12 Entech Instruments Inc. Ventilator-coupled sampling device and method
JP2019184288A (ja) 2018-04-03 2019-10-24 国立研究開発法人量子科学技術研究開発機構 気体分析装置及びこの装置に適用するマスク
US20210386959A1 (en) 2018-12-05 2021-12-16 Aires Medical LLC Mechanical ventilator
US11400250B2 (en) 2018-12-05 2022-08-02 Aires Medical LLC Mechanical ventilator with non-invasive option
US11135392B2 (en) 2018-12-05 2021-10-05 Aires Medical LLC Mechanical ventilator
US12589213B2 (en) 2018-12-05 2026-03-31 Goldman Sephoric Llc Mechanical ventilator with non-invasive option
US11229763B2 (en) 2018-12-05 2022-01-25 Aires Medical LLC Mechanical ventilator with oxygen concentrator
US11359733B2 (en) 2018-12-05 2022-06-14 Beech Health, Inc. Check valve
US20220076783A1 (en) 2018-12-20 2022-03-10 Merck Sharp & Dohme Corp. Methods and Systems for the Precise Identification of Immunogenic Tumor Neoantigens
US11678829B2 (en) * 2019-04-17 2023-06-20 Masimo Corporation Physiological monitoring device attachment assembly
WO2021061247A2 (en) 2019-06-29 2021-04-01 Zeteo Tech, Inc. Methods and systems for detecting aerosol particles without using complex organic maldi matrices
CN114585903B (zh) 2019-09-23 2023-08-04 泽特奥科技公司 快速自主检测气溶胶粒子的系统和方法
KR102630689B1 (ko) 2020-04-03 2024-01-29 제테오 테크, 인코포레이티드 호기 및 에어로졸 분석을 이용한 호흡기 질환 진단
US20210318208A1 (en) 2020-04-09 2021-10-14 Hygieia Sciences LLC Method of Detection of Diseases Related to Coronavirus Infection by Breath Analysis
US12533047B2 (en) 2020-04-19 2026-01-27 John J. Daniels Mask-based diagnostic system using exhaled breath condensate
CA3177161A1 (en) 2020-04-28 2021-11-04 Rahul RAMAKRISHNAN Object detection and tracking for automated operation of vehicles and machinery
US20220183587A1 (en) 2020-12-14 2022-06-16 Avisa Diagnostics, Inc. Breath sampling system
EP4312749A4 (en) 2021-03-31 2025-07-09 Zeteo Tech Inc DIAGNOSIS OF RESPIRATORY DISEASES BY CAPTURE OF AEROSOLIZED BIOMATERIAL PARTICLES USING FIXED BED SYSTEMS AND METHODS
SE546321C2 (en) 2021-04-08 2024-10-01 Pinsalus Ab System for breath analysis comprising a breath sampling apparatus and a sample preparation apparatus
WO2022251882A1 (en) 2021-05-28 2022-12-01 Entech Instruments Inc. System and method of gas sampling for trace-level analysis of chemical compounds
US20240423497A1 (en) 2021-11-02 2024-12-26 Pexa Ab A device and method for determining a respiratory system infection from exhaled breath

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001500365A (ja) * 1996-07-05 2001-01-16 ノバルティス アクチエンゲゼルシャフト Ｐ５３とｍｄｍ２の間の相互作用の阻害剤
JP2005257373A (ja) * 2004-03-10 2005-09-22 Yokohama Tlo Co Ltd 呼気採取装置
JP2016539314A (ja) * 2011-12-12 2016-12-15 ノバルティス アーゲー インフルエンザウイルス血球凝集素のためのアッセイ法
US20200147333A1 (en) * 2018-11-09 2020-05-14 Hound Labs, Inc. Breath sample systems for use with ventilators
WO2021041571A1 (en) * 2019-08-26 2021-03-04 Zeteo Tech, Inc. Diagnosis of tuberculosis and other diseases using exhaled breath

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