JP2024517945A - メニン－ｍｌｌ相互作用の阻害剤 - Google Patents

メニン－ｍｌｌ相互作用の阻害剤 Download PDF

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Publication number
JP2024517945A
JP2024517945A JP2023569958A JP2023569958A JP2024517945A JP 2024517945 A JP2024517945 A JP 2024517945A JP 2023569958 A JP2023569958 A JP 2023569958A JP 2023569958 A JP2023569958 A JP 2023569958A JP 2024517945 A JP2024517945 A JP 2024517945A
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JP
Japan
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alkyl
cycloalkyl
halo
alkoxy
compound
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JP2023569958A
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Japanese (ja)
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JP2024517945A5 (https=
Inventor
カカティアン サルバシオン
エス．クルカーニ サントッシュ
クマール サマンタ スワパン
ベンカット レディ バーシンハ
エム．マクギーハン ジェラード
ウィリアム　エイチ．ミラー
ポール キャンプ ニコラス
Original Assignee
シンダックス ファーマシューティカルズ， インコーポレイテッド
ヴァイティー ファーマシューティカルズ，エルエルシー
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Application filed by シンダックス ファーマシューティカルズ， インコーポレイテッド, ヴァイティー ファーマシューティカルズ，エルエルシー filed Critical シンダックス ファーマシューティカルズ， インコーポレイテッド
Publication of JP2024517945A publication Critical patent/JP2024517945A/ja
Publication of JP2024517945A5 publication Critical patent/JP2024517945A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2023569958A 2021-05-14 2022-05-13 メニン－ｍｌｌ相互作用の阻害剤 Pending JP2024517945A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163188704P 2021-05-14 2021-05-14
US63/188,704 2021-05-14
PCT/US2022/029271 WO2022241265A1 (en) 2021-05-14 2022-05-13 Inhibitors of the menin-mll interaction

Publications (2)

Publication Number Publication Date
JP2024517945A true JP2024517945A (ja) 2024-04-23
JP2024517945A5 JP2024517945A5 (https=) 2025-05-19

Family

ID=84029448

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023569958A Pending JP2024517945A (ja) 2021-05-14 2022-05-13 メニン－ｍｌｌ相互作用の阻害剤

Country Status (14)

Country Link
US (2) US11919901B2 (https=)
EP (1) EP4337203A4 (https=)
JP (1) JP2024517945A (https=)
KR (1) KR20240047338A (https=)
CN (1) CN117956992A (https=)
AR (1) AR125866A1 (https=)
AU (1) AU2022274325A1 (https=)
BR (1) BR112023023463A2 (https=)
CA (1) CA3213074A1 (https=)
CL (1) CL2023003327A1 (https=)
IL (1) IL308476A (https=)
MX (1) MX2023013515A (https=)
TW (1) TW202311262A (https=)
WO (1) WO2022241265A1 (https=)

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WO2017214367A1 (en) 2016-06-10 2017-12-14 Vitae Pharmaceuticals, Inc. Inhibitors of the menin-mll interaction
EP4132932A4 (en) 2020-04-07 2024-04-17 Syndax Pharmaceuticals, Inc. COMBINATIONS OF MENIN INHIBITORS AND CYP3A4 INHIBITORS AND METHODS OF USE THEREOF
IL308476A (en) 2021-05-14 2024-01-01 Syndax Pharmaceuticals Inc Inhibitors of the menin-mil interaction
AR130379A1 (es) * 2022-09-02 2024-12-04 Hutchmed Ltd Compuestos de triazina y usos de los mismos
CN120529900A (zh) 2022-11-24 2025-08-22 奥莱松基因组股份有限公司 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合
WO2025106901A1 (en) * 2023-11-17 2025-05-22 Quanta Therapeutics, Inc. Combination cancer therapies with a kras modulator and an rtk-mapk pathway inhibitor
WO2025106905A1 (en) * 2023-11-17 2025-05-22 Quanta Therapeutics, Inc. Combination therapies with a kras modulator and an immunomodulator inhibitor

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WO2020045334A1 (ja) * 2018-08-27 2020-03-05 大日本住友製薬株式会社 光学活性なアザビシクロ環誘導体

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WO2020045334A1 (ja) * 2018-08-27 2020-03-05 大日本住友製薬株式会社 光学活性なアザビシクロ環誘導体

Also Published As

Publication number Publication date
BR112023023463A2 (pt) 2024-01-30
IL308476A (en) 2024-01-01
AR125866A1 (es) 2023-08-23
CA3213074A1 (en) 2022-11-17
AU2022274325A1 (en) 2023-10-05
EP4337203A4 (en) 2025-04-09
US20230021684A1 (en) 2023-01-26
US20240400564A1 (en) 2024-12-05
MX2023013515A (es) 2024-02-29
KR20240047338A (ko) 2024-04-12
CL2023003327A1 (es) 2024-05-03
US11919901B2 (en) 2024-03-05
EP4337203A1 (en) 2024-03-20
TW202311262A (zh) 2023-03-16
CN117956992A (zh) 2024-04-30
WO2022241265A1 (en) 2022-11-17

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