JP2024515344A - 補体成分３の発現を阻害するための組成物及び方法 - Google Patents

補体成分３の発現を阻害するための組成物及び方法 Download PDF

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JP2024515344A
JP2024515344A JP2023564255A JP2023564255A JP2024515344A JP 2024515344 A JP2024515344 A JP 2024515344A JP 2023564255 A JP2023564255 A JP 2023564255A JP 2023564255 A JP2023564255 A JP 2023564255A JP 2024515344 A JP2024515344 A JP 2024515344A
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acceptable salt
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nucleotides
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JPWO2022226127A5 (https=
JP2024515344A5 (https=
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メリッサ ラサロ，
スーザン ファース マックナイト，
ヘンリク ティー． ドゥデク，
ジヘ パク，
ボブ デール ブラウン，
チェンジュン ライ，
スンクォン キム，
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AstraZeneca Ireland Ltd
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AstraZeneca Ireland Ltd
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JP2023564255A 2021-04-20 2022-04-20 補体成分３の発現を阻害するための組成物及び方法 Pending JP2024515344A (ja)

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TWI868755B (zh) 2022-06-24 2025-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
WO2024169907A1 (zh) * 2023-02-17 2024-08-22 苏州时安生物技术有限公司 一种调节补体C3表达的siRNA、其缀合物和药物组合物及用途
CN121488036A (zh) * 2023-07-21 2026-02-06 上海舶望制药有限公司 用于抑制补体成分3(c3)表达的组合物和方法
WO2025168134A1 (zh) * 2024-02-08 2025-08-14 北京安龙生物医药有限公司 靶向补体成分c3基因的寡核苷酸及其用途
CN121154665B (zh) * 2025-11-21 2026-02-27 天津医科大学第二医院 尿苷在防治糖尿病肾病药物开发过程中及药物中的应用

Citations (12)

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JP2009518008A (ja) * 2005-11-30 2009-05-07 イントラディグム コーポレイション 遺伝子発現をノックダウンするため、そして固形臓器および細胞の移植を改善するためにｓｉＲＮＡを使用する組成物および方法
WO2010042755A2 (en) * 2008-10-08 2010-04-15 Chimeros Inc. Chimeric therapeutics, compositions, and methods for using same
JP2010187668A (ja) * 2002-11-14 2010-09-02 Dharmacon Inc 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
JP2017500031A (ja) * 2013-12-12 2017-01-05 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 補体成分ｉＲＮＡ組成物及びその使用方法
WO2019089922A1 (en) * 2017-11-01 2019-05-09 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof
JP2020500157A (ja) * 2016-10-17 2020-01-09 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｃ３阻害のための組み合わせ治療
WO2020104669A1 (en) * 2018-11-23 2020-05-28 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of c3 in a cell
WO2021037941A1 (en) * 2019-08-27 2021-03-04 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of c3 in a cell
WO2021081026A1 (en) * 2019-10-22 2021-04-29 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof
WO2021163654A1 (en) * 2020-02-14 2021-08-19 Apellis Pharmaceuticals, Inc. Rnas for complement inhibition
WO2022159158A1 (en) * 2021-01-22 2022-07-28 Alnylam Pharmaceuticals, Inc. Modified double stranded oligonucleotides
WO2022251484A1 (en) * 2021-05-26 2022-12-01 Apellis Pharmaceuticals, Inc. Treatment of complement-mediated disorders

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JP2010187668A (ja) * 2002-11-14 2010-09-02 Dharmacon Inc 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
JP2009518008A (ja) * 2005-11-30 2009-05-07 イントラディグム コーポレイション 遺伝子発現をノックダウンするため、そして固形臓器および細胞の移植を改善するためにｓｉＲＮＡを使用する組成物および方法
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WO2022226127A1 (en) 2022-10-27
CO2023014681A2 (es) 2024-01-25
EP4326876A1 (en) 2024-02-28
KR20230173116A (ko) 2023-12-26
JP2025100729A (ja) 2025-07-03
US20250002908A1 (en) 2025-01-02
CN117295819A (zh) 2023-12-26
IL307721A (en) 2023-12-01
CA3177629A1 (en) 2022-10-27
AU2022261922A1 (en) 2023-10-26
EP4326876A4 (en) 2026-04-08
MX2023012385A (es) 2024-02-07

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