CN117295819A - 用于抑制补体组分3表达的组合物和方法 - Google Patents

用于抑制补体组分3表达的组合物和方法 Download PDF

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Publication number
CN117295819A
CN117295819A CN202280034163.4A CN202280034163A CN117295819A CN 117295819 A CN117295819 A CN 117295819A CN 202280034163 A CN202280034163 A CN 202280034163A CN 117295819 A CN117295819 A CN 117295819A
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oligonucleotide
pharmaceutically acceptable
acceptable salt
nucleotides
rnai oligonucleotide
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CN202280034163.4A
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Chinese (zh)
Inventor
梅丽莎·拉莎诺
苏珊·法阿斯·麦克奈特
亨里克·T·杜德克
智慧·帕克
鲍勃·黛尔·布朗
振荣·赖
圣光·金
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AstraZeneca Ireland Ltd
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AstraZeneca Ireland Ltd
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Publication of CN117295819A publication Critical patent/CN117295819A/zh
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/531—Stem-loop; Hairpin

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CN202280034163.4A 2021-04-20 2022-04-20 用于抑制补体组分3表达的组合物和方法 Pending CN117295819A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163177254P 2021-04-20 2021-04-20
US63/177,254 2021-04-20
PCT/US2022/025648 WO2022226127A1 (en) 2021-04-20 2022-04-20 Compositions and methods for inhibiting complement component 3 expression

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Publication Number Publication Date
CN117295819A true CN117295819A (zh) 2023-12-26

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CN202280034163.4A Pending CN117295819A (zh) 2021-04-20 2022-04-20 用于抑制补体组分3表达的组合物和方法

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US (1) US20250002908A1 (https=)
EP (1) EP4326876A4 (https=)
JP (2) JP2024515344A (https=)
KR (1) KR20230173116A (https=)
CN (1) CN117295819A (https=)
AU (1) AU2022261922A1 (https=)
BR (1) BR112023021703A2 (https=)
CA (1) CA3177629A1 (https=)
CO (1) CO2023014681A2 (https=)
IL (1) IL307721A (https=)
MX (1) MX2023012385A (https=)
WO (1) WO2022226127A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025168134A1 (zh) * 2024-02-08 2025-08-14 北京安龙生物医药有限公司 靶向补体成分c3基因的寡核苷酸及其用途
CN121154665A (zh) * 2025-11-21 2025-12-19 天津医科大学第二医院 尿苷在防治糖尿病肾病药物开发过程中及药物中的应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI868755B (zh) 2022-06-24 2025-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
WO2024169907A1 (zh) * 2023-02-17 2024-08-22 苏州时安生物技术有限公司 一种调节补体C3表达的siRNA、其缀合物和药物组合物及用途
CN121488036A (zh) * 2023-07-21 2026-02-06 上海舶望制药有限公司 用于抑制补体成分3(c3)表达的组合物和方法

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EP2305812A3 (en) * 2002-11-14 2012-06-06 Dharmacon, Inc. Fuctional and hyperfunctional sirna
WO2007064846A2 (en) * 2005-11-30 2007-06-07 Intradigm Corporation COMPOSITIONS AND METHODS OF USING siRNA TO KNOCKDOWN GENE EXPRESSION AND TO IMPROVE SOLID ORGAN AND CELL TRANSPLANTATION
WO2010042755A2 (en) * 2008-10-08 2010-04-15 Chimeros Inc. Chimeric therapeutics, compositions, and methods for using same
SG10201804960RA (en) * 2013-12-12 2018-07-30 Alnylam Pharmaceuticals Inc Complement component irna compositions and methods of use thereof
RU2019113301A (ru) * 2016-10-17 2020-11-17 Апеллис Фармасьютикалс, Инк. Комбинированная терапия для ингибирования с3
AU2018360697A1 (en) * 2017-11-01 2020-05-14 Alnylam Pharmaceuticals, Inc. Complement component C3 iRNA compositions and methods of use thereof
CA3119234A1 (en) * 2018-11-23 2020-05-28 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of c3 in a cell
EP4022060A1 (en) * 2019-08-27 2022-07-06 Silence Therapeutics GmbH Nucleic acids for inhibiting expression of c3 in a cell
TW202134435A (zh) * 2019-10-22 2021-09-16 美商阿尼拉製藥公司 補體成分ｃ３ ｉｒｎａ組成物及其使用方法
CN115335524A (zh) * 2020-02-14 2022-11-11 阿佩利斯制药有限公司 用于补体抑制的rna
MX2023008469A (es) * 2021-01-22 2023-11-22 Alnylam Pharmaceuticals Inc Oligonucleotidos de doble hebra modificados.
WO2022251484A1 (en) * 2021-05-26 2022-12-01 Apellis Pharmaceuticals, Inc. Treatment of complement-mediated disorders

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025168134A1 (zh) * 2024-02-08 2025-08-14 北京安龙生物医药有限公司 靶向补体成分c3基因的寡核苷酸及其用途
CN121154665A (zh) * 2025-11-21 2025-12-19 天津医科大学第二医院 尿苷在防治糖尿病肾病药物开发过程中及药物中的应用
CN121154665B (zh) * 2025-11-21 2026-02-27 天津医科大学第二医院 尿苷在防治糖尿病肾病药物开发过程中及药物中的应用

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BR112023021703A2 (pt) 2024-01-30
WO2022226127A1 (en) 2022-10-27
CO2023014681A2 (es) 2024-01-25
EP4326876A1 (en) 2024-02-28
KR20230173116A (ko) 2023-12-26
JP2025100729A (ja) 2025-07-03
US20250002908A1 (en) 2025-01-02
IL307721A (en) 2023-12-01
CA3177629A1 (en) 2022-10-27
AU2022261922A1 (en) 2023-10-26
JP2024515344A (ja) 2024-04-09
EP4326876A4 (en) 2026-04-08
MX2023012385A (es) 2024-02-07

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