JP2024515061A - 複素環誘導体、医薬組成物およびがんの治療または軽快におけるこれらの使用 - Google Patents
複素環誘導体、医薬組成物およびがんの治療または軽快におけるこれらの使用 Download PDFInfo
- Publication number
- JP2024515061A JP2024515061A JP2023561897A JP2023561897A JP2024515061A JP 2024515061 A JP2024515061 A JP 2024515061A JP 2023561897 A JP2023561897 A JP 2023561897A JP 2023561897 A JP2023561897 A JP 2023561897A JP 2024515061 A JP2024515061 A JP 2024515061A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- egfr
- mmol
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21167278 | 2021-04-07 | ||
| EP21167278.7 | 2021-04-07 | ||
| PCT/EP2022/059295 WO2022214606A1 (en) | 2021-04-07 | 2022-04-07 | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024515061A true JP2024515061A (ja) | 2024-04-04 |
| JP2024515061A5 JP2024515061A5 (https=) | 2025-05-21 |
Family
ID=75426525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023561897A Pending JP2024515061A (ja) | 2021-04-07 | 2022-04-07 | 複素環誘導体、医薬組成物およびがんの治療または軽快におけるこれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20240327394A1 (https=) |
| EP (1) | EP4320109A1 (https=) |
| JP (1) | JP2024515061A (https=) |
| KR (1) | KR20230167092A (https=) |
| CN (1) | CN117355512A (https=) |
| AR (1) | AR125312A1 (https=) |
| AU (1) | AU2022253869A1 (https=) |
| BR (1) | BR112023020538A2 (https=) |
| CA (1) | CA3212085C (https=) |
| IL (1) | IL307402A (https=) |
| MX (1) | MX2023011814A (https=) |
| TW (1) | TW202304882A (https=) |
| WO (1) | WO2022214606A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102940906B1 (ko) * | 2017-11-20 | 2026-03-18 | 톨레모 테라퓨틱스 아게 | 진단 방법 |
| WO2025027560A1 (en) | 2023-08-01 | 2025-02-06 | Fondazione Istituto Italiano Di Tecnologia | New rhoj/cdc42 inhibitors developed for the treatment of cancer, benign tumors, retinal disorders, vascular disorders, and cardiomyopathies |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020518595A (ja) * | 2017-05-02 | 2020-06-25 | フォンダツィオーネ・イスティトゥート・イタリアーノ・ディ・テクノロジャＦｏｎｄａｚｉｏｎｅ Ｉｓｔｉｔｕｔｏ Ｉｔａｌｉａｎｏ Ｄｉ Ｔｅｃｎｏｌｏｇｉａ | 癌、網膜障害及び心筋症の治療のための三置換ピリミジン化合物及び組成物 |
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| DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3483949D1 (de) | 1983-09-26 | 1991-02-21 | Udo Dr Med Ehrenfeld | Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr. |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| AU756693B2 (en) | 1997-09-29 | 2003-01-23 | Novartis Ag | Stabilized bioactive preparations and methods of use |
| EP1034826A1 (en) | 1999-03-05 | 2000-09-13 | Reuter Chemische Apparatebau | Co-crystallization process |
| JP2001089452A (ja) | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | ピリミジン誘導体 |
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| WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
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| MX2016004570A (es) | 2013-10-11 | 2016-09-08 | Genentech Inc | Uso de inhibidores del bromodominio de cbp/ep300 para la inmunoterapia del cáncer. |
| PL3089971T3 (pl) | 2014-01-01 | 2021-01-25 | Medivation Technologies Llc | Związki i sposoby ich zastosowania |
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| BR112022025911A2 (pt) | 2020-06-25 | 2023-01-10 | Tolremo Therapeutics Ag | Combinação de um inibidor de bromodomínio de cbp/p300 e um inibidor de egfr para uso no tratamento de um cpcnp com egfr mutante |
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-
2022
- 2022-04-07 IL IL307402A patent/IL307402A/en unknown
- 2022-04-07 WO PCT/EP2022/059295 patent/WO2022214606A1/en not_active Ceased
- 2022-04-07 CA CA3212085A patent/CA3212085C/en active Active
- 2022-04-07 KR KR1020237038144A patent/KR20230167092A/ko active Pending
- 2022-04-07 EP EP22721083.8A patent/EP4320109A1/en active Pending
- 2022-04-07 MX MX2023011814A patent/MX2023011814A/es unknown
- 2022-04-07 AU AU2022253869A patent/AU2022253869A1/en active Pending
- 2022-04-07 CN CN202280026783.3A patent/CN117355512A/zh active Pending
- 2022-04-07 JP JP2023561897A patent/JP2024515061A/ja active Pending
- 2022-04-07 TW TW111113263A patent/TW202304882A/zh unknown
- 2022-04-07 BR BR112023020538A patent/BR112023020538A2/pt unknown
- 2022-04-07 US US18/285,800 patent/US20240327394A1/en active Pending
- 2022-04-07 AR ARP220100874A patent/AR125312A1/es unknown
-
2025
- 2025-04-15 US US19/179,235 patent/US12595258B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020518595A (ja) * | 2017-05-02 | 2020-06-25 | フォンダツィオーネ・イスティトゥート・イタリアーノ・ディ・テクノロジャＦｏｎｄａｚｉｏｎｅ Ｉｓｔｉｔｕｔｏ Ｉｔａｌｉａｎｏ Ｄｉ Ｔｅｃｎｏｌｏｇｉａ | 癌、網膜障害及び心筋症の治療のための三置換ピリミジン化合物及び組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3212085A1 (en) | 2022-10-13 |
| BR112023020538A2 (pt) | 2024-01-23 |
| US20240327394A1 (en) | 2024-10-03 |
| MX2023011814A (es) | 2023-10-13 |
| TW202304882A (zh) | 2023-02-01 |
| IL307402A (en) | 2023-12-01 |
| US12595258B2 (en) | 2026-04-07 |
| WO2022214606A1 (en) | 2022-10-13 |
| US20250243191A1 (en) | 2025-07-31 |
| CA3212085C (en) | 2025-02-11 |
| EP4320109A1 (en) | 2024-02-14 |
| AU2022253869A1 (en) | 2023-10-05 |
| CN117355512A (zh) | 2024-01-05 |
| AR125312A1 (es) | 2023-07-05 |
| KR20230167092A (ko) | 2023-12-07 |
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