JP2024514880A5 - - Google Patents

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Publication number
JP2024514880A5
JP2024514880A5 JP2023562909A JP2023562909A JP2024514880A5 JP 2024514880 A5 JP2024514880 A5 JP 2024514880A5 JP 2023562909 A JP2023562909 A JP 2023562909A JP 2023562909 A JP2023562909 A JP 2023562909A JP 2024514880 A5 JP2024514880 A5 JP 2024514880A5
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JP
Japan
Prior art keywords
nucleotides
positions
rnai oligonucleotide
sequence
antisense strand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023562909A
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English (en)
Japanese (ja)
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JP2024514880A (ja
JP7877355B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/024657 external-priority patent/WO2022221430A1/en
Publication of JP2024514880A publication Critical patent/JP2024514880A/ja
Publication of JP2024514880A5 publication Critical patent/JP2024514880A5/ja
Application granted granted Critical
Publication of JP7877355B2 publication Critical patent/JP7877355B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2023562909A 2021-04-14 2022-04-13 Pnpla3発現を調節するための組成物及び方法 Active JP7877355B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163174932P 2021-04-14 2021-04-14
US63/174,932 2021-04-14
PCT/US2022/024657 WO2022221430A1 (en) 2021-04-14 2022-04-13 Compositions and methods for modulating pnpla3 expression

Publications (3)

Publication Number Publication Date
JP2024514880A JP2024514880A (ja) 2024-04-03
JP2024514880A5 true JP2024514880A5 (enExample) 2025-04-11
JP7877355B2 JP7877355B2 (ja) 2026-06-22

Family

ID=81580082

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023562909A Active JP7877355B2 (ja) 2021-04-14 2022-04-13 Pnpla3発現を調節するための組成物及び方法

Country Status (13)

Country Link
US (2) US12084662B2 (enExample)
EP (1) EP4323519A1 (enExample)
JP (1) JP7877355B2 (enExample)
KR (1) KR20230171431A (enExample)
CN (1) CN117120613A (enExample)
AR (1) AR125351A1 (enExample)
AU (1) AU2022258459A1 (enExample)
BR (1) BR112023021109A2 (enExample)
CA (1) CA3209418A1 (enExample)
IL (1) IL307625A (enExample)
MX (1) MX2023012216A (enExample)
TW (2) TW202500748A (enExample)
WO (1) WO2022221430A1 (enExample)

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Publication number Priority date Publication date Assignee Title
KR20230171431A (ko) 2021-04-14 2023-12-20 다이서나 파마수이티컬, 인크. Pnpla3 발현을 조절하기 위한 조성물 및 방법
EP4622982A1 (en) 2022-11-23 2025-10-01 Eli Lilly and Company Methods of synthesizing a targeting ligand-conjugated nucleotide phosphoramidite
JP7812495B2 (ja) 2022-11-23 2026-02-09 イーライ リリー アンド カンパニー 4’-ホスフェート類似体ヌクレオチドホスホラミダイトを合成する方法
WO2024182446A2 (en) * 2023-02-28 2024-09-06 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
WO2026130520A1 (zh) * 2024-12-20 2026-06-25 正大天晴药业集团股份有限公司 靶向pnpla3的双链核糖核酸

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